NOAEL Data REACH Registered Cosmetic Ingredient

2-Amino-5-ethylphenol hydrochloride

Also known as: UNII-B5IWK1V8FX, Colorex AEP, Phenol, 2-amino-5-ethyl-, hydrochloride

CAS 149861-22-3

2-Amino-5-ethylphenol hydrochloride (CAS 149861-22-3) is a chemical substance. Key regulatory status: REACH registered, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for 2-Amino-5-Ethylphenol HCl →

SOURCE noael studies public
NOAEL studies
37
SOURCE chemical inventory jurisdictions
Regulatory lists
0
SOURCE eu clp annex vi
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 9 fields
Name
2-Amino-5-ethylphenol hydrochloride
CAS Number
149861-22-3
DTXSID
DTXSID40164418
Molecular Formula
C8H11NO.ClH
InChI Key
SZAJCDAIQPZDSA-UHFFFAOYSA-N
Monoisotopic Mass
173.060742
Synonyms
UNII-B5IWK1V8FXColorex AEPPhenol, 2-amino-5-ethyl-, hydrochloride

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 2 records
Dye

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 37 of 37 studies
ValueUnitEndpointRouteSpeciesSource
7--oral-UnifiedCodex:SCCS_SHADOW:beta.noael_studies
B5IWK1V8FXUNIIFDA UNII substance identifier--openFDA substances
B5IWK1V8FXUNIIFDA UNII substance identifier--openFDA substances
B5IWK1V8FXUNIIFDA UNII substance identifier--openFDA substances
B5IWK1V8FXUNIIFDA UNII substance identifier--openFDA substances
=0.026mg/kg bw/dNOAELoralratSCCS_vision_codex
=0.026mg/kg bw/dNOAELoralratSCCS_vision_codex
=0.026mg/kg bw/dNOAELoralratSCCS_vision_codex
=0.026mg/kg bw/dNOAELoralratSCCS_vision_codex
=7-NOAELoral-SCCS_vision_codex
=7-NOAELoral-SCCS_vision_codex
=7-NOAELoral-SCCS_vision_codex
=7-NOAELoral-SCCS_vision_codex
=16mg/kg bw/dayNOAEL-ratSCCS_vision_codex
=16mg/kg bw/dNOAELoralratSCCS_vision_codex
=16mg/kg bw/dayNOAEL-ratSCCS_vision_codex
=16mg/kg bw/dNOAELoralratSCCS_vision_codex
=16mg/kg bw/dayNOAEL-ratSCCS_vision_codex
=16mg/kg bw/dNOAELoralratSCCS_vision_codex
=16mg/kg bw/dayNOAEL-ratSCCS_vision_codex
=16mg/kg bw/dNOAELoralratSCCS_vision_codex
=74mg/kg bw/dayNOAELoral-SCCS_vision_codex
=74mg/kg bw/dayNOAELoral-SCCS_vision_codex
=74mg/kg bw/dayNOAELoral-SCCS_vision_codex
=74mg/kg bw/dayNOAELoral-SCCS_vision_codex
=369mg/kg bw/dayNOAELoral-SCCS_vision_codex
=369mg/kg bw/dayNOAELoral-SCCS_vision_codex
=369mg/kg bw/dayNOAELoral-SCCS_vision_codex
=369mg/kg bw/dayNOAELoral-SCCS_vision_codex
=0.026mg/kg bw/ddermal absorptionoralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
=16mg/kg bw/ddermal absorptionoralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
74mg/kg bw/daydevelopmental toxicityoral-UnifiedCodex:SCCS_SHADOW:beta.noael_studies
369mg/kg bw/daydevelopmental toxicityoral-UnifiedCodex:SCCS_SHADOW:beta.noael_studies
16mg/kg bw/daygenotoxicity-ratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
16mg/kg bw/dayrepeated dose toxicityoralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
369mg/kg bw/dayrepeated dose toxicityoralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
74mg/kg bw/dayreproductive toxicityoralmouseUnifiedCodex:SCCS_SHADOW:beta.noael_studies

Showing 37 of 37 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records
StatusNameEC NumberLink
Registered2-amino-5-ethylphenol;hydrochloride480-270-8ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed_with_terms
Conditions
Specific information requirements: Obligations to provide information apply. These obligations are: 1. A person introducing this chemical must tell us in writing within 28 calendar days if any of the following circumstances have occurred in relation to their introduction (importation or manufacture): a. the introduction volume of the chemical exceeds 1 tonne per annum b. the concentration in hair dye products has increased from 1% c. the chemical is used in hair dye products intended for sale to the public d. the chemical has begun to be formulated into products in Australia e. additional information becomes available to the person as to the adverse effects of the oxidative reaction products created during hair dye use 2. A person who introduces this chemical must tell us in writing within 28 calendar days if they become aware of any of the following circumstances, namely, that since the assessment under the Industrial Chemicals (Notification and Assessment) Act 1989: a. the function or use of the chemical has changed, or is likely to change, significantly; b. the amount of the chemical being introduced has increased, or is likely to increase, significantly; c. in the case of a chemical not manufactured, or proposed to be manufactured, in Australia at the time of the assessment—it has begun to be manufactured in Australia; d. the method of manufacture of the chemical in Australia has changed, or is likely to change, in a way that may result in an increased risk of an adverse effect of the chemical on occupational health and safety, public health or the environment; e. additional information has become available to the person as to an adverse effect of the chemical on occupational health and safety, public health or the environment.

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
prohibited
Max
1.0%
Category
Colorant
View full cosmetic safety profile →

Frequently Asked Questions

What is the NOAEL for 2-Amino-5-ethylphenol hydrochloride?

2-Amino-5-ethylphenol hydrochloride has 37 NOAEL studies in the database. The lowest reported value is 7 mg/kg bw/day via oral. Source: UnifiedCodex:SCCS_SHADOW:beta.noael_studies.

Is 2-Amino-5-ethylphenol hydrochloride used in cosmetics?

Yes, 2-Amino-5-ethylphenol hydrochloride is also indexed as a cosmetic ingredient under the name 2-Amino-5-Ethylphenol HCl. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 2-Amino-5-ethylphenol hydrochloride come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.

Does 2-Amino-5-ethylphenol hydrochloride have different safety status in cosmetics vs industrial chemicals?

2-Amino-5-ethylphenol hydrochloride is prohibited in EU cosmetics at max 1.0% but has active industrial GHS classifications (H302, H314, H315, H317, H319, H335, H400, H410).

Is 2-Amino-5-ethylphenol hydrochloride used outside industrial chemicals?

2-Amino-5-ethylphenol hydrochloride also appears in cosmetics databases.