What is the NOAEL for N-Methyl-p-aminophenol?
N-Methyl-p-aminophenol has 13 NOAEL studies in the database. The lowest reported value is 0.047 mg/kg via oral in rat. Source: SCCS Opinion.
NOAEL Data
Cosmetic Ingredient
N-Methyl-p-aminophenol
Also known as: 3-13-00-01007, BRN 1363740, EINECS 205-768-2, NSC 7311, UNII-11W1883EFB (+6 more)
CAS 150-75-4
N-Methyl-p-aminophenol (CAS 150-75-4) is a chemical substance. Key regulatory status: cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ILO ICSC.
Cross-Vertical Regulatory Divergence
N-Methyl-p-aminophenol is classified GHS CMR hazard (H302, H332, H341, H410, H317, H373) in the chemicals database but is restricted in EU cosmetics at max III/223.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
NOAEL studies
NOAEL studies
13
SOURCE
Chemical inventory jurisdictions
Regulatory lists
0
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
16 fields
Name
N-Methyl-p-aminophenol
CAS Number
150-75-4
Molecular Formula
C7H9NO
InChI Key
ZFIQGRISGKSVAG-UHFFFAOYSA-N
Monoisotopic Mass
123.068414
Synonyms
3-13-00-01007BRN 1363740EINECS 205-768-2NSC 7311UNII-11W1883EFBN-Methyl-4-aminophenolN-methyl-4-hydroxyanilineParamethylaminophenolp-(Methylamino)phenolp-Methylaminophenol4-methylaminophenol
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
WHO/JECFA
1 records
| Field | Value |
|---|---|
| Short-term Effects | The substance is irritating to the eyes and skin. |
| Long-term Effects | Repeated or prolonged contact may cause skin sensitization. The substance may have effects on the blood. This may result in lesions of blood cells. |
| Routes of Exposure | The substance can be absorbed into the body by ingestion. |
Functional Uses
Industrial and product-use categories associated with this substance.
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EPA CPDat
2 records
Dye
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 13 of 13 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 5 | mg/kg/day | - | - | - | Regulatory source |
| 125 | mg/kg/day | - | - | - | Regulatory source |
| 11W1883EFB | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =0.047 | mg/kg | NOAEL | oral | rat | SCCS Opinion |
| =5 | mg/kg/day | NOAEL | - | - | SCCS Opinion |
| =5 | mg/kg | NOAEL | oral | rat | SCCS Opinion |
| =10 | mg/kg/day | NOAEL | - | - | SCCS Opinion |
| =10 | mg/kg bw/day | NOAEL | oral | rat | SCCS Opinion |
| =125 | mg/kg/day | NOAEL | - | - | SCCS Opinion |
| 10 | mg/kg/day | carcinogenicity | - | - | Regulatory source |
| =0.047 | mg/kg | developmental toxicity | oral | rat | Regulatory source |
| =5 | mg/kg | developmental toxicity | oral | rat | Regulatory source |
| 10 | mg/kg bw/day | developmental toxicity | oral | rat | Regulatory source |
Showing 13 of 13 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
III/223
Category
Hair Dyes
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
CHEMBL1741003
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Frequently Asked Questions
Is N-Methyl-p-aminophenol used in cosmetics?
Yes, N-Methyl-p-aminophenol is also indexed as a cosmetic ingredient under the name P-METHYLAMINOPHENOL. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for N-Methyl-p-aminophenol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does N-Methyl-p-aminophenol have different safety status in cosmetics vs industrial chemicals?
N-Methyl-p-aminophenol is classified GHS CMR hazard (H302, H332, H341, H410, H317, H373) in the chemicals database but is restricted in EU cosmetics at max III/223.
Is N-Methyl-p-aminophenol used outside industrial chemicals?
N-Methyl-p-aminophenol also appears in cosmetics, pharmaceutical databases.