What is the NOAEL for Drometrizole trisiloxane?
Drometrizole trisiloxane has 4 NOAEL studies in the database. The lowest reported value is HC22845I1X UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Drometrizole trisiloxane
Also known as: Phenol, 2-(2H-benzotriazol-2-yl)-4-methyl-6-[2-methyl-3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]-1-disiloxanyl]propyl]-, Phenol, 2-(2H-benzotriazol-2-yl)-4-methyl-6-[2-methyl-3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propyl]-, 2-(2H-Benzotriazol-2-yl)-4-methyl-6-[2-methyl-3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]-1-disiloxanyl]propyl]phenol, 2-(2H-Benzotriazol-2-yl)-4-methyl-6-[2-methyl-3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propyl]phenol, OR 10154 (+1 more)
CAS 155633-54-8
Drometrizole trisiloxane (CAS 155633-54-8) is a chemical substance. Key regulatory status: REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
4
SOURCE
chemical inventory jurisdictions
Regulatory lists
2
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
12 fields
Name
Drometrizole trisiloxane
CAS Number
155633-54-8
DTXSID
DTXSID40431753
Molecular Formula
C24H39N3O3Si3
InChI Key
HUVYTMDMDZRHBN-UHFFFAOYSA-N
Monoisotopic Mass
501.229922
Synonyms
Phenol, 2-(2H-benzotriazol-2-yl)-4-methyl-6-[2-methyl-3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]-1-disiloxanyl]propyl]-Phenol, 2-(2H-benzotriazol-2-yl)-4-methyl-6-[2-methyl-3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propyl]-2-(2H-Benzotriazol-2-yl)-4-methyl-6-[2-methyl-3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]-1-disiloxanyl]propyl]phenol2-(2H-Benzotriazol-2-yl)-4-methyl-6-[2-methyl-3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propyl]phenolOR 10154EC 422-940-4
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
3 records
UV stabilizer
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
2 records
| List | Keyword | Source |
|---|---|---|
| Canada; pharmaceutical | DrugBank | DrugBank |
| Europe; Personal care | European Commission | CosIng |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 4 of 4 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| HC22845I1X | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| HC22845I1X | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| HC22845I1X | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| HC22845I1X | UNII | FDA UNII substance identifier | - | - | openFDA substances |
Showing 4 of 4 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | SL-01 | 423-660-5 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed_with_terms
Conditions
Specific information requirements: Obligations to provide information apply. You must tell us within 28 days if the circumstances of your importation or manufacture (introduction) are different to those in our assessment.
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
Approved under EU Cosmetics Regulation Annex VI; concentration limits apply
Category
active
Frequently Asked Questions
What regulatory lists include Drometrizole trisiloxane?
Drometrizole trisiloxane appears on 2 regulatory/inventory lists including Canada; pharmaceutical, Europe; Personal care. Source: EPA CPDat.
Is Drometrizole trisiloxane used in cosmetics?
Yes, Drometrizole trisiloxane is also indexed as a cosmetic ingredient under the name Drometrizole Trisiloxane. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Drometrizole trisiloxane come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
Is Drometrizole trisiloxane used outside industrial chemicals?
Drometrizole trisiloxane also appears in cosmetics databases.