Also known as: 2-Propenoic acid, 2-ethyl-2-[[(1-oxo-2-propenyl)oxy]methyl]-1,3-propanediyl ester, Acrylic acid, 1,1,1-(trihydroxymethyl)propane triester, EINECS 239-701-3, NK Ester A TMPT, 1,3-Propanediol, 2-ethyl-2-(hydroxymethyl)-, triacrylate (+3 more)
CAS 15625-89-5
Trimethylolpropane triacrylate (CAS 15625-89-5) is a chemical substance with GHS signal word Warning; key hazard signal: H351; H315; H319; H317; H400; H410. Key regulatory status: REACH registered, 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, IARC, ECHA REACH.
View cosmetic safety profile for Trimethylolpropane Triacrylate →
Trimethylolpropane triacrylate is prohibited in EU cosmetics but has active industrial GHS classifications (H351, H315, H319, H317, H400, H410).
CAS, identifiers, formula, and alternate names for the matched substance record.
Carcinogenic hazard classification from IARC monograph evaluations.
| Group | Meaning | Evaluated | Volume |
|---|---|---|---|
| Group 2B | Possibly carcinogenic | 2018 | 122 |
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Carc. 2; Skin Irrit. 2; Eye Irrit. 2; Skin Sens. 1; Aquatic Acute 1; Aquatic Chronic 1 | H351; H315; H319; H317; H400; H410 | GHS08; GHS07; GHS09 | Warning |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| OEHHA Proposition 65 (1/2023) | California Office of Environmental Health Hazard Assessment | OEHHA Proposition 65 List |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =17.1 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 0.013 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 0.13 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 4B67KGL96S | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 4B67KGL96S | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 4B67KGL96S | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 4B67KGL96S | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2B | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 2B | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 2B | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 2 | unitless | IARC group | - | - | NTP_ICE_cancer |
| >=130 | mg/kg bw/day | NOAEL | oral | Rabbit | ToxValDB_ECHA_IUCLID |
| =240 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =300 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| >500 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| 3 | mg/kg bw/day | POLY-3 lowest dose | Dermal | Mouse | NTP_ICE_cancer |
| 3 | mg/kg | Top dose | Dermal | Mouse | NTP_ICE_cancer |
Showing 17 of 17 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2-ethyl-2-[[(1-oxoallyl)oxy]methyl]-1,3-propanediyl diacrylate; 2,2-bis(acryloyloxymethyl)butyl acrylate; trimethylolpropane triacrylate | 239-701-3 | ECHA overview → |
Australian industrial chemicals inventory status and applicable conditions.
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS pharmaceutical records from drug and bioactivity sources.
Trimethylolpropane triacrylate (CAS 15625-89-5) is classified under EU CLP Annex VI as Carc. 2; Skin Irrit. 2; Eye Irrit. 2; Skin Sens. 1; Aquatic Acute 1; Aquatic Chronic 1 with signal word Warning. Hazard statements: H351; H315; H319; H317; H400; H410. Source: EU CLP Annex VI (ECHA).
Trimethylolpropane triacrylate has 17 NOAEL studies in the database. The lowest reported value is 0.013 % via Dermal in Mouse. Source: NTP_ICE_skin_sensitization.
Trimethylolpropane triacrylate appears on 1 regulatory/inventory list including OEHHA Proposition 65 (1/2023). Source: EPA CPDat.
Trimethylolpropane triacrylate is classified by IARC as Group 2B — possibly carcinogenic to humans (evaluated 2018). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.
Yes, Trimethylolpropane triacrylate is also indexed as a cosmetic ingredient under the name Trimethylolpropane Triacrylate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Trimethylolpropane triacrylate is prohibited in EU cosmetics but has active industrial GHS classifications (H351, H315, H319, H317, H400, H410).
Trimethylolpropane triacrylate also appears in cosmetics, pharmaceutical databases.