What is the NOAEL for Aspartame?
Aspartame has 100 NOAEL studies in the database. The lowest reported value is 0.5 mg/kg bw/day. Source: WHO/JECFA.
NOAEL Data
IARC Group 2B
Cosmetic Ingredient
Aspartame
Also known as: 3-Amino-N-(alpha-carboxyphenethyl)succinamic acid N-methyl ester, stereoisomer, 3-Amino-N-(alpha-methoxycarbonylphenethyl) succinamic acid, Aspartame, L,L-alpha-, N-L-alpha-Aspartyl-L-phenylalanine 1-methyl ester, EINECS 245-261-3 (+14 more)
CAS 22839-47-0
Aspartame (CAS 22839-47-0) is a chemical substance; key hazard signal: IARC Group 2B. Key regulatory status: 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, IARC.
SOURCE
NOAEL studies
NOAEL studies
100
SOURCE
Chemical inventory jurisdictions
Regulatory lists
4
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
25 fields
Name
Aspartame
CAS Number
22839-47-0
DTXSID
DTXSID0020107
Molecular Formula
C14H18N2O5
InChI Key
IAOZJIPTCAWIRG-QWRGUYRKSA-N
Monoisotopic Mass
294.121572
Synonyms
3-Amino-N-(alpha-carboxyphenethyl)succinamic acid N-methyl ester, stereoisomer3-Amino-N-(alpha-methoxycarbonylphenethyl) succinamic acidAspartame, L,L-alpha-N-L-alpha-Aspartyl-L-phenylalanine 1-methyl esterEINECS 245-261-3Methyl L-alpha-aspartyl-L-phenylalanateMethyl N-L-alpha-aspartyl-L-phenylalaninateMethyl L-aspartyl-L-phenylalanine1-Methyl N-L-alpha-aspartyl-L-phenylalanineTri-sweetAspartamumUNII-Z0H242BBR1
IARC Carcinogen Classification
Carcinogenic hazard classification from IARC monograph evaluations.
SOURCE
IARC Monographs on the Identification of Carcinogenic Hazards to Humans
1 records
| Group | Meaning | Evaluated | Volume |
|---|---|---|---|
| Group 2B | Possibly carcinogenic | 2023 | 134 |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
10 records
Flavouring and nutrientDeodorizer
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| pharmaceutical | US International Trade Commission | CPCat |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 50 of 100 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 53.8124788963568 | uM | AC50 | - | - | NTP ICE endocrine |
| 38.6854899573427 | uM | ACC | - | - | NTP ICE endocrine |
| range:0-0.50.5 | mg/kg bw/day | ADI | - | - | WHO/JECFA |
| range:0-0.50.5 | mg/kg bw/day | ADI | - | - | WHO/JECFA |
| range:0-0.50.5 | mg/kg bw/day | ADI | - | - | WHO/JECFA |
| range:0-0.50.5 | mg/kg bw/day | ADI | - | - | WHO/JECFA |
| range:0-2.52.5 | mg/kg bw/day | ADI | - | - | WHO/JECFA |
| range:0-2.52.5 | mg/kg bw/day | ADI | - | - | WHO/JECFA |
| range:0-2.52.5 | mg/kg bw/day | ADI | - | - | WHO/JECFA |
| range:0-2.52.5 | mg/kg bw/day | ADI | - | - | WHO/JECFA |
| range:0-33 | mg/kg bw/day | ADI | - | - | WHO/JECFA |
| range:0-33 | mg/kg bw/day | ADI | - | - | WHO/JECFA |
| range:0-33 | mg/kg bw/day | ADI | - | - | WHO/JECFA |
| range:0-33 | mg/kg bw/day | ADI | - | - | WHO/JECFA |
| range:0-55 | mg/kg bw/day | ADI | oral | - | WHO/JECFA |
| range:0-55 | mg/kg bw/day | ADI | - | - | WHO/JECFA |
| range:0-55 | mg/kg bw/day | ADI | oral | - | WHO/JECFA |
| range:0-55 | mg/kg bw/day | ADI | - | - | WHO/JECFA |
| range:0-7.57.5 | mg/kg bw/day | ADI | - | - | WHO/JECFA |
| range:0-7.57.5 | mg/kg bw/day | ADI | - | - | WHO/JECFA |
| =7.5 | mg/kg bw/day | ADI | - | - | WHO/JECFA |
| =7.5 | mg/kg bw/day | ADI | - | - | WHO/JECFA |
| range:0-7.57.5 | mg/kg bw/day | ADI | - | - | WHO/JECFA |
| range:0-7.57.5 | mg/kg bw/day | ADI | - | - | WHO/JECFA |
| range:0-1010 | mg/kg bw/day | ADI | - | - | WHO/JECFA |
| range:0-1010 | mg/kg bw/day | ADI | - | - | WHO/JECFA |
| range:0-1010 | mg/kg bw/day | ADI | - | - | WHO/JECFA |
| range:0-1010 | mg/kg bw/day | ADI | - | - | WHO/JECFA |
| <=40 | mg/kg | ADI | oral | Human | WHO/JECFA |
| range:0-4040 | mg/kg bw/day | ADI | - | - | WHO/JECFA |
| range:0-4040 | mg/kg bw/day | ADI | - | - | WHO/JECFA |
| =40 | mg/kg bw/day | ADI | - | Consumers | EFSA |
| =40 | mg/kg bw/day | ADI | - | Bird | WHO/JECFA |
| =40 | mg/kg bw/day | ADI | - | Consumers | EFSA |
| =40 | mg/kg bw/day | ADI | - | Bird | WHO/JECFA |
| range:0-4040 | mg/kg bw/day | ADI | - | - | WHO/JECFA |
| range:0-4040 | mg/kg bw/day | ADI | - | - | WHO/JECFA |
| =50 | mg/kg bw/day | ADI | - | - | WHO/JECFA |
| =50 | mg/kg bw/day | ADI | - | - | WHO/JECFA |
| =250 | mg/kg bw/day | ADI | - | Rat | WHO/JECFA |
| =250 | mg/kg bw/day | ADI | - | Rat | WHO/JECFA |
| Z0H242BBR1 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| Z0H242BBR1 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| Z0H242BBR1 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| Z0H242BBR1 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2B | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 2B | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 2B | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| >10000 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| >10000 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
Showing 50 of 100 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Cosmetic Ingredient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
ASPARTAME
ChEMBL Phase
3
Adverse Events
3
Bioactivity
3
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA
1 records
ADI: 40 mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Aspartame?
Aspartame appears on 3 regulatory/inventory lists including pharmaceutical, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), Canada; pharmaceutical. Source: EPA CPDat.
Is Aspartame a carcinogen according to IARC?
Aspartame is classified by IARC as Group 2B — possibly carcinogenic to humans (evaluated 2023). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.
Is Aspartame used in cosmetics?
Yes, Aspartame is also indexed as a cosmetic ingredient under the name Aspartame. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Aspartame come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Aspartame used outside industrial chemicals?
Aspartame also appears in cosmetics, pharmaceutical, food safety, cannabis databases.