What is the NOAEL for (2E)-3,7-dimethylocta-2,6-dien-1-yl 2-methylpropanoate?
(2E)-3,7-dimethylocta-2,6-dien-1-yl 2-methylpropanoate has 11 NOAEL studies in the database. The lowest reported value is P6D2F72907 UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
(2E)-3,7-dimethylocta-2,6-dien-1-yl 2-methylpropanoate
Also known as: geranyl isobutyrate, trans-3-7-Dimethyl-2,6-octadienyl isobutyrate, 3,7-Dimethyl-2,6-octadienyl isobutyrate, (E)-, 3,7-Dimethyl-2,6-octadien-1-yl isobutyrate, trans-, 3,7-Dimethyl-2,6-octadien-1-yl 2-methylpropanoate, trans- (+9 more)
CAS 2345-26-8
(2E)-3,7-dimethylocta-2,6-dien-1-yl 2-methylpropanoate (CAS 2345-26-8) is a chemical substance. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
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NOAEL studies
NOAEL studies
11
SOURCE
Chemical inventory jurisdictions
Regulatory lists
4
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EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
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DSSTox identifiers
20 fields
Name
(2E)-3,7-dimethylocta-2,6-dien-1-yl 2-methylpropanoate
CAS Number
2345-26-8
DTXSID
DTXSID8051889
Molecular Formula
C14H24O2
InChI Key
OGJYXQFXLSCKTP-UKTHLTGXSA-N
Monoisotopic Mass
224.17763
Synonyms
geranyl isobutyratetrans-3-7-Dimethyl-2,6-octadienyl isobutyrate3,7-Dimethyl-2,6-octadienyl isobutyrate, (E)-3,7-Dimethyl-2,6-octadien-1-yl isobutyrate, trans-3,7-Dimethyl-2,6-octadien-1-yl 2-methylpropanoate, trans-3,7-Dimethyl-2,6-octadienyl 2-methylpropanoate, (E)-EINECS 219-062-7FEMA No. 2513Geranyl 2-methylpropanoateIsobutyric acid, 3,7-dimethyl-2,6-octadienyl ester, trans-Isobutyric acid, 3,7-dimethyl-2,6-octadienyl ester, (E)-2,6-Octadien-1-ol, 3,7-dimethyl-, isobutyrate, trans-
Functional Uses
Industrial and product-use categories associated with this substance.
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EPA CPDat
8 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 11 of 11 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| P6D2F72907 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| P6D2F72907 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| P6D2F72907 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| P6D2F72907 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 6480 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP ICE skin sensitization |
| >5000 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =345 | mg/kg bw/day | NOAEL | oral | Rat | EFSA |
| =345 | mg/kg bw/day | NOAEL | oral: feed | Rat | EFSA |
| =345 | mg/kg bw/day | NOAEL | oral: feed | Rat | EFSA |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP ICE skin sensitization |
Showing 11 of 11 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
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ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Geranyl isobutyrate | 219-062-7 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
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EFSA
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
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Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include (2E)-3,7-dimethylocta-2,6-dien-1-yl 2-methylpropanoate?
(2E)-3,7-dimethylocta-2,6-dien-1-yl 2-methylpropanoate appears on 4 regulatory/inventory lists including IFRA Transparency, Europe, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), and 1 more. Source: EPA CPDat.
Is (2E)-3,7-dimethylocta-2,6-dien-1-yl 2-methylpropanoate used in cosmetics?
Yes, (2E)-3,7-dimethylocta-2,6-dien-1-yl 2-methylpropanoate is also indexed as a cosmetic ingredient under the name Geranyl Isobutyrate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for (2E)-3,7-dimethylocta-2,6-dien-1-yl 2-methylpropanoate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is (2E)-3,7-dimethylocta-2,6-dien-1-yl 2-methylpropanoate used outside industrial chemicals?
(2E)-3,7-dimethylocta-2,6-dien-1-yl 2-methylpropanoate also appears in cosmetics, food safety, cannabis databases.