What is the NOAEL for Clotrimazole?
Clotrimazole has 14 NOAEL studies in the database. The lowest reported value is 0 % via Dermal. Source: NTP ICE skin sensitization.
NOAEL Data
Cosmetic Ingredient
Clotrimazole
Also known as: 1H-Imidazole, 1-[(2-chlorophenyl)diphenylmethyl]-, 1-((2-Chlorophenyl)diphenylmethyl)-1H-imidazole (9CI), 1H-Imidazole, 1-((2-chlorophenyl)diphenylmethyl)-, Imidazole, 1-(o-chloro-alpha,alpha-diphenylbenzyl)-, 5-23-04-00291 (+15 more)
CAS 23593-75-1
Clotrimazole (CAS 23593-75-1) is a chemical substance. Key regulatory status: 8 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat.
Cross-Vertical Regulatory Divergence
Clotrimazole is classified GHS Danger (H302, H311, H315, H319, H361, H373, H400, H410) in the chemicals database but is restricted in EU cosmetics at max 0.5%.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
NOAEL studies
NOAEL studies
14
SOURCE
Chemical inventory jurisdictions
Regulatory lists
8
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
25 fields
Name
Clotrimazole
CAS Number
23593-75-1
Molecular Formula
C22H17ClN2
InChI Key
VNFPBHJOKIVQEB-UHFFFAOYSA-N
Monoisotopic Mass
344.108026
Synonyms
1H-Imidazole, 1-[(2-chlorophenyl)diphenylmethyl]-1-((2-Chlorophenyl)diphenylmethyl)-1H-imidazole (9CI)1H-Imidazole, 1-((2-chlorophenyl)diphenylmethyl)-Imidazole, 1-(o-chloro-alpha,alpha-diphenylbenzyl)-5-23-04-00291Bis-phenyl-(2-chlorophenyl)(1-imidazoyl)methaneBRN 0622318Canestene(2-Chlorophenyl)diphenyl-1-imidazolylmethane1-((o-Chloro-phenyl)diphenylmethyl)imidazole1-((2-Chlorophenyl)diphenylmethyl)-1H-imidazole(Chlorotrityl)imidazole
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
2 records
BiocideAnti-dandruff
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
8 records
| List | Keyword | Source |
|---|---|---|
| active_ingredient; Australia | Australian Pesticides and Veterinary Medicines Authority | CPCat |
| pharmaceutical | US International Trade Commission | CPCat |
| pharmaceutical | FDA | United States Food and Drug Administration (FDA) |
| pharmaceutical | FDA | United States Food and Drug Administration (FDA) |
| pharmaceutical | FDA | United States Food and Drug Administration (FDA) |
| detected; Europe; surface_water; wastewater | Drinking Water Inspectorate | CPCat |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; consumer_product; Substances in Products - Canada (4/2014) | Government of Canada | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 14 of 14 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 0.7308 | uM | AC50 | - | - | NTP ICE endocrine |
| 31.88 | uM | AC50 | - | - | NTP ICE endocrine |
| 0.907 | uM | ACC | - | - | NTP ICE endocrine |
| 30.25 | uM | ACC | - | - | NTP ICE endocrine |
| 14.8 | ug/mL | CV75 | Dermal | - | NTP ICE skin sensitization |
| 77.1 | uL/min/10^6 cells | Clint | - | Human | NTP ICE adme parameters |
| 0 | % | Depletion Cys | Dermal | - | NTP ICE skin sensitization |
| 4.8 | % | EC3 | Dermal | Mouse | NTP ICE skin sensitization |
| G07GZ97H65 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.00953 | fraction | Fu | - | Human | NTP ICE adme parameters |
| =100 | mg/kg/org | LOEL | oral | Rat | ToxValDB ECOTOX |
| 0 | unitless | Model Score | - | - | NTP ICE endocrine |
| 0.00844 | unitless | Model Score | - | - | NTP ICE endocrine |
| 0.0715 | unitless | Model Score | - | - | NTP ICE endocrine |
Showing 14 of 14 studies
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
0.5%
Category
Cosmetic Ingredient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
CLOTRIMAZOLE
ChEMBL Phase
4
Adverse Events
1959
Bioactivity
91
Frequently Asked Questions
What regulatory lists include Clotrimazole?
Clotrimazole appears on 5 regulatory/inventory lists including active_ingredient; Australia, pharmaceutical, detected; Europe; surface_water; wastewater, and 2 more. Source: EPA CPDat.
Is Clotrimazole used in cosmetics?
Yes, Clotrimazole is also indexed as a cosmetic ingredient under the name Clotrimazole. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Clotrimazole come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does Clotrimazole have different safety status in cosmetics vs industrial chemicals?
Clotrimazole is classified GHS Danger (H302, H311, H315, H319, H361, H373, H400, H410) in the chemicals database but is restricted in EU cosmetics at max 0.5%.
Is Clotrimazole used outside industrial chemicals?
Clotrimazole also appears in cosmetics, pharmaceutical databases.