What is the NOAEL for (E)-beta-Damascone?
(E)-beta-Damascone has 13 NOAEL studies in the database. The lowest reported value is 4.508 uM via Dermal. Source: NTP_ICE_skin_sensitization.
NOAEL Data
REACH Registered
Cosmetic Ingredient
(E)-beta-Damascone
Also known as: (E)-1-(2,6,6-Trimethyl-1-cyclohexen-1-yl)-2-buten-1-one, 2-Buten-1-one, 1-(2,6,6-trimethyl-1-cyclohexen-1-yl)-, (2E)-, (2E)-1-(2,6,6-Trimethyl-1-cyclohexen-1-yl)-2-buten-1-one, (E)-β-Damascone, 2-Buten-1-one, 1-(2,6,6-trimethyl-1-cyclohexen-1-yl)-, (E)- (+15 more)
CAS 23726-91-2
(E)-beta-Damascone (CAS 23726-91-2) is a chemical substance. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
13
SOURCE
chemical inventory jurisdictions
Regulatory lists
4
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
(E)-beta-Damascone
CAS Number
23726-91-2
DTXSID
DTXSID7051890
Molecular Formula
C13H20O
InChI Key
BGTBFNDXYDYBEY-FNORWQNLSA-N
Monoisotopic Mass
192.151415
Synonyms
(E)-1-(2,6,6-Trimethyl-1-cyclohexen-1-yl)-2-buten-1-one2-Buten-1-one, 1-(2,6,6-trimethyl-1-cyclohexen-1-yl)-, (2E)-(2E)-1-(2,6,6-Trimethyl-1-cyclohexen-1-yl)-2-buten-1-one(E)-β-Damascone2-Buten-1-one, 1-(2,6,6-trimethyl-1-cyclohexen-1-yl)-, (E)-Damascone betatrans-2,6,6-Trimethyl-1-crotonylcyclohex-1-enetrans-β-Damasconeβ-Damasconeβ-Damascone, trans-DAMASCONE, β-BRN 2046078
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
25 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| consumer_product | P&G | Proctor & Gamble |
| Europe | European Commission | Fl@vis |
| Europe; Personal care; restricted | European Commission | CosIng |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 13 of 13 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 22.58 | ug/mL | CD54, EC200 | Dermal | - | NTP_ICE_skin_sensitization |
| 12 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| 30.8 | ug/mL | CV75 | Dermal | - | NTP_ICE_skin_sensitization |
| 4.508 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| 6.7 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| I75J0X33Q6 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| I75J0X33Q6 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| I75J0X33Q6 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| I75J0X33Q6 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 56.73 | uM | IC50 | Dermal | - | NTP_ICE_skin_sensitization |
| 29.85 | ratio | Imax | Dermal | - | NTP_ICE_skin_sensitization |
| =2920 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =50 | mg/kg bw/day | LEL | oral | Chicken | ToxValDB_EFSA |
Showing 13 of 13 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | (E)-1-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2-buten-1-one | 245-842-1 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL4565078
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include (E)-beta-Damascone?
(E)-beta-Damascone appears on 4 regulatory/inventory lists including IFRA Transparency, consumer_product, Europe, and 1 more. Source: EPA CPDat.
Is (E)-beta-Damascone used in cosmetics?
Yes, (E)-beta-Damascone is also indexed as a cosmetic ingredient under the name Rose Ketone-3. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for (E)-beta-Damascone come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is (E)-beta-Damascone used outside industrial chemicals?
(E)-beta-Damascone also appears in cosmetics, pharmaceutical, cannabis databases.