NOAEL Data REACH Registered Cosmetic Ingredient

3,3'-(1,1,3,3-Tetramethyldisiloxane-1,3-diyl)dipropan-1-amine

Also known as: 1-Propanamine, 3,3'-(1,1,3,3-tetramethyl-1,3-disiloxanediyl)bis-, 4-04-00-04093, Bis(3-aminopropyl)tetramethyl disiloxane, Bis(gamma-aminopropyl)tetramethyldisiloxane, 1,3-Bis(3-aminopropyl)tetramethyldisiloxane (+5 more)

CAS 2469-55-8

3,3'-(1,1,3,3-Tetramethyldisiloxane-1,3-diyl)dipropan-1-amine (CAS 2469-55-8) is a chemical substance. Key regulatory status: REACH registered, cosmetic ingredient cross-reference; source data from EPA ToxValDB, AICIS, ECHA REACH.

View cosmetic safety profile for Amino Bispropyl Dimethicone →

Cross-Vertical Regulatory Divergence

3,3'-(1,1,3,3-Tetramethyldisiloxane-1,3-diyl)dipropan-1-amine is classified GHS Danger (H314, H315, H319, H411) in the chemicals database but is allowed in EU cosmetics.

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 16 fields

Name

3,3'-(1,1,3,3-Tetramethyldisiloxane-1,3-diyl)dipropan-1-amine

CAS Number

2469-55-8

DTXSID

DTXSID3044621

Molecular Formula

C10H28N2OSi2

InChI Key

GPXCORHXFPYJEH-UHFFFAOYSA-N

Monoisotopic Mass

248.174017

Synonyms

1-Propanamine, 3,3'-(1,1,3,3-tetramethyl-1,3-disiloxanediyl)bis-4-04-00-04093Bis(3-aminopropyl)tetramethyl disiloxaneBis(gamma-aminopropyl)tetramethyldisiloxane1,3-Bis(3-aminopropyl)tetramethyldisiloxane1,3-Bis(3-aminopropyl)-1,1,3,3-tetramethyldisiloxaneBRN 1760876EINECS 219-588-7Oxybis((3-aminopropyl)dimethylsilane)Silane, oxybis((3-aminopropyl)dimethyl-

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 5 of 5 studies

Value	Unit	Endpoint	Route	Species	Source
1	unitless	EPA Classification	Ocular	Rabbit	NTP_ICE_eye_irritation
MM4N3X9HK9	UNII	FDA UNII substance identifier	-	-	openFDA substances
MM4N3X9HK9	UNII	FDA UNII substance identifier	-	-	openFDA substances
MM4N3X9HK9	UNII	FDA UNII substance identifier	-	-	openFDA substances
MM4N3X9HK9	UNII	FDA UNII substance identifier	-	-	openFDA substances

Showing 5 of 5 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	3,3'-(1,1,3,3-tetramethyldisiloxane-1,3-diyl)bispropylamine	219-588-7	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL CHEMBL3183692

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Frequently Asked Questions

What is the NOAEL for 3,3'-(1,1,3,3-Tetramethyldisiloxane-1,3-diyl)dipropan-1-amine?

3,3'-(1,1,3,3-Tetramethyldisiloxane-1,3-diyl)dipropan-1-amine has 5 NOAEL studies in the database. The lowest reported value is 1 unitless via Ocular in Rabbit. Source: NTP_ICE_eye_irritation.

Is 3,3'-(1,1,3,3-Tetramethyldisiloxane-1,3-diyl)dipropan-1-amine used in cosmetics?

Yes, 3,3'-(1,1,3,3-Tetramethyldisiloxane-1,3-diyl)dipropan-1-amine is also indexed as a cosmetic ingredient under the name Amino Bispropyl Dimethicone. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 3,3'-(1,1,3,3-Tetramethyldisiloxane-1,3-diyl)dipropan-1-amine come from?

Safety data is sourced from EPA ToxValDB, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Does 3,3'-(1,1,3,3-Tetramethyldisiloxane-1,3-diyl)dipropan-1-amine have different safety status in cosmetics vs industrial chemicals?

3,3'-(1,1,3,3-Tetramethyldisiloxane-1,3-diyl)dipropan-1-amine is classified GHS Danger (H314, H315, H319, H411) in the chemicals database but is allowed in EU cosmetics.

Is 3,3'-(1,1,3,3-Tetramethyldisiloxane-1,3-diyl)dipropan-1-amine used outside industrial chemicals?

3,3'-(1,1,3,3-Tetramethyldisiloxane-1,3-diyl)dipropan-1-amine also appears in cosmetics, pharmaceutical databases.