What is the NOAEL for Methyl dihydrojasmonate?
Methyl dihydrojasmonate has 17 NOAEL studies in the database. The lowest reported value is 29.3 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Methyl dihydrojasmonate
Also known as: Methyl 3-oxo-2-pentyl-cyclopentaneacetate, Methyl (3-oxo-2-pentylcyclopentyl)acetate, EINECS 246-495-9, FEMA No. 3408, Hedione (+4 more)
CAS 24851-98-7
Methyl dihydrojasmonate (CAS 24851-98-7) is a chemical substance. Key regulatory status: REACH registered, 9 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
Methyl dihydrojasmonate is classified GHS Danger (H301, H311, H314, H318, H330) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
17
SOURCE
chemical inventory jurisdictions
Regulatory lists
9
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
15 fields
Name
Methyl dihydrojasmonate
CAS Number
24851-98-7
DTXSID
DTXSID2029325
Molecular Formula
C13H22O3
InChI Key
KVWWIYGFBYDJQC-UHFFFAOYSA-N
Monoisotopic Mass
226.156895
Synonyms
Methyl 3-oxo-2-pentyl-cyclopentaneacetateMethyl (3-oxo-2-pentylcyclopentyl)acetateEINECS 246-495-9FEMA No. 3408HedioneKharismalMethyl (2-pentyl-3-oxocyclopentyl)acetateUNII-3GW44CIE3YCyclopentaneacetic acid, 3-oxo-2-pentyl-, methyl ester
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
FragranceAbrasiveSoftener and conditionerDeodorizerFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
9 records
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| Europe | European Commission | Fl@vis |
| Cleaning products and household care - air freshener; Europe | Danish Environmental Protection Agency | Danish EPA |
| artificial_sweat; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| air; Cleaning products and household care - air freshener; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 17 of 17 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =29.3 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 3GW44CIE3Y | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3GW44CIE3Y | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3GW44CIE3Y | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3GW44CIE3Y | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 1500 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| 6200 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| 10000 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| 11000 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| 13500 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| >5000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| =100 | mg/kg bw/day | NOAEL | oral: feed | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =100 | mg/kg bw/day | NOAEL | oral: feed | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =100 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 17 of 17 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Methyl 3-oxo-2-pentylcyclopentaneacetate | 246-495-9 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
aroma_chemical
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
DIHYDROJASMONIC ACID, METHYL ESTER
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Methyl dihydrojasmonate?
Methyl dihydrojasmonate appears on 9 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, Europe, Cleaning products and household care - air freshener; Europe, and 6 more. Source: EPA CPDat.
Is Methyl dihydrojasmonate used in cosmetics?
Yes, Methyl dihydrojasmonate is also indexed as a cosmetic ingredient under the name Methyl Dihydrojasmonate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Methyl dihydrojasmonate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Methyl dihydrojasmonate have different safety status in cosmetics vs industrial chemicals?
Methyl dihydrojasmonate is classified GHS Danger (H301, H311, H314, H318, H330) in the chemicals database but is allowed in EU cosmetics.
Is Methyl dihydrojasmonate used outside industrial chemicals?
Methyl dihydrojasmonate also appears in cosmetics, pharmaceutical, cannabis databases.