What is the NOAEL for Butylated hydroxyanisole?
Butylated hydroxyanisole has 98 NOAEL studies in the database. The lowest reported value is 0.5 mg/kg via oral in Human. Source: ToxValDB_WHO_JECFA_ADI.
NOAEL Data
IARC Group 2B
Prop 65
REACH Registered
Cosmetic Ingredient
Butylated hydroxyanisole
Also known as: (1,1-Dimethylethyl)-4-methoxyphenol, 1,1-(Dimethylethyl)-4-methoxyphenol, Phenol, tert-butyl-4-methoxy-, terc-butil-4-metoxifenol, tert-Butyl-4-hydroxyanisole (+15 more)
CAS 25013-16-5
Butylated hydroxyanisole (CAS 25013-16-5) is a chemical substance; key hazard signal: IARC Group 2B. Key regulatory status: California Proposition 65, REACH registered, 31 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, IARC, ECHA REACH, CA Prop 65.
Cross-Vertical Regulatory Divergence
Butylated hydroxyanisole is classified GHS CMR hazard (H302, H315, H319, H335, H351, H361, H361f, H411) in the chemicals database but is restricted in EU cosmetics at max 0.07%.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
98
SOURCE
chemical inventory jurisdictions
Regulatory lists
31
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
23 fields
Name
Butylated hydroxyanisole
CAS Number
25013-16-5
DTXSID
DTXSID7020215
Synonyms
(1,1-Dimethylethyl)-4-methoxyphenol1,1-(Dimethylethyl)-4-methoxyphenolPhenol, tert-butyl-4-methoxy-terc-butil-4-metoxifenoltert-Butyl-4-hydroxyanisoletert-Butyl-4-methoxyphenolPhenol, (1,1-dimethylethyl)-4-methoxy-BHATenox BHAAnisole, butylated hydroxy-Antrancine 12Butyl hydroxyanisole
IARC Carcinogen Classification
Carcinogenic hazard classification from IARC monograph evaluations.
SOURCE
IARC Monographs on the Identification of Carcinogenic Hazards to Humans
1 records
| Group | Meaning | Evaluated | Volume |
|---|---|---|---|
| Group 2B | Possibly carcinogenic | 1987 | 40, Sup 7 |
California Proposition 65
California OEHHA listing status and toxicity category.
SOURCE
California OEHHA Proposition 65 List
1 records
| Chemical | Toxicity Type | Cancer | Developmental | Listed |
|---|---|---|---|---|
| - | cancer | Yes | No | - |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
13 records
AntioxidantDeodorizerFragranceBiocideFlavouring and nutrientFillerFood preservativeOxidizing agent
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
31 records
| List | Keyword | Source |
|---|---|---|
| drinking_water; Europe; manufacturing; plastic_additive | Belgaqua | CPCat |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| Europe | Danish Environmental Protection Agency | Danish EPA |
| consumer_product; Europe | Danish Environmental Protection Agency | Danish EPA |
| Europe; Raw materials | Danish Environmental Protection Agency | Danish EPA |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| OEHHA Proposition 65 (3/2019) | STATE OF CALIFORNIA ENVIRONMENTAL PROTECTION AGENCY | OEHHA Proposition 65 List |
| IFRA Transparency | IFRA | IFRA |
| detected; drinking_water; MN Chemical Screening | EPA | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | EPA | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | EPA | State of Minnesota |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| children | Maine Department of Environmental Protection | State of Maine |
| OEHHA Proposition 65 (1/2023) | California Office of Environmental Health Hazard Assessment | OEHHA Proposition 65 List |
| children; WA Children's Safe Product Act (4/2020) | State of Washington Department of Ecology | State of Washington |
| children | Vermont Department of Health | State of Vermont |
| children | Oregon Health Authority | State of Oregon |
| Europe; pharmaceutical | Danish Environmental Protection Agency | Danish EPA |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| OEHHA Proposition 65 (3/2019) | STATE OF CALIFORNIA ENVIRONMENTAL PROTECTION AGENCY | OEHHA Proposition 65 List |
| IFRA Transparency | IFRA | IFRA |
| detected; drinking_water; MN Chemical Screening | EPA | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | EPA | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | EPA | State of Minnesota |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| children | Maine Department of Environmental Protection | State of Maine |
| OEHHA Proposition 65 (1/2023) | California Office of Environmental Health Hazard Assessment | OEHHA Proposition 65 List |
| children; WA Children's Safe Product Act (4/2020) | State of Washington Department of Ecology | State of Washington |
| children | Vermont Department of Health | State of Vermont |
| children | Oregon Health Authority | State of Oregon |
| Europe; pharmaceutical | Danish Environmental Protection Agency | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 50 of 98 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| <=0.5 | mg/kg | ADI | oral | Human | ToxValDB_WHO_JECFA_ADI |
| =1 | mg/kg bw/day | ADI | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| =1 | mg/kg bw/day | ADI | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| AB4000 | ug/day | California Proposition 65 NSRL | - | - | California Proposition 65 |
| AB4000 | ug/day | California Proposition 65 NSRL | - | - | California Proposition 65 |
| AB4000 | ug/day | California Proposition 65 NSRL | - | - | California Proposition 65 |
| ABcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| ABcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| ABcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| REK4960K2U | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| REK4960K2U | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| REK4960K2U | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| REK4960K2U | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2B | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 2B | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 2B | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 2 | unitless | IARC group | - | - | NTP_ICE_cancer |
| =500 | mg/kg bw/day | LOEL | oral | Mouse | ToxValDB_ECOTOX |
| =0.0029 | mg/kg bw/d | NOAEL | - | - | SCCS_vision_codex |
| =0.0029 | mg/kg bw/d | NOAEL | - | - | SCCS_vision_codex |
| =0.0029 | mg/kg bw/d | NOAEL | - | - | SCCS_vision_codex |
| =0.0029 | mg/kg bw/d | NOAEL | - | - | SCCS_vision_codex |
| =0.079 | mg/kg bw/d | NOAEL | oral | - | SCCS_vision_codex |
| =0.079 | mg/kg bw/d | NOAEL | oral | - | SCCS_vision_codex |
| =0.079 | mg/kg bw/d | NOAEL | oral | - | SCCS_vision_codex |
| =0.079 | mg/kg bw/d | NOAEL | oral | - | SCCS_vision_codex |
| =0.082 | mg/kg bw/d | NOAEL | oral | - | SCCS_vision_codex |
| =0.082 | mg/kg bw/d | NOAEL | oral | - | SCCS_vision_codex |
| =0.082 | mg/kg bw/d | NOAEL | oral | - | SCCS_vision_codex |
| =0.082 | mg/kg bw/d | NOAEL | oral | - | SCCS_vision_codex |
| 50 | mg/kg bw/day | NOAEL | oral | swine | COSMOS_DB |
| =50 | mg/kg bw/d | NOAEL | oral | rat | SCCS_vision_codex |
| =50 | mg/kg bw/d | NOAEL | oral | rat | SCCS_vision_codex |
| =50 | mg/kg bw/d | NOAEL | oral | rat | SCCS_vision_codex |
| =50 | mg/kg bw/d | NOAEL | oral | rat | SCCS_vision_codex |
| =55 | mg/kg bw/d | NOAEL | oral | rat | SCCS_vision_codex |
| =55 | mg/kg bw/d | NOAEL | oral | rat | SCCS_vision_codex |
| =55 | mg/kg bw/d | NOAEL | oral | rat | SCCS_vision_codex |
| =55 | mg/kg bw/d | NOAEL | oral | rat | SCCS_vision_codex |
| 60 | mg/kg bw/day | NOAEL | oral | dog | COSMOS_DB |
| 100 | mg/kg bw/day | NOAEL | oral | dog | COSMOS_DB |
| =100 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| =100 | mg/kg bw/day | NOAEL | oral: unspecified | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =100 | mg/kg bw/d | NOAEL | oral | rat | CIR_vision_codex |
| =100 | mg/kg bw/day | NOAEL | oral: unspecified | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =100 | mg/kg bw/d | NOAEL | oral | rat | CIR_vision_codex |
| =100 | mg/kg bw/d | NOAEL | oral | rat | CIR_vision_codex |
| =100 | mg/kg bw/d | NOAEL | oral | rat | CIR_vision_codex |
| 120 | mg/kg bw/day | NOAEL | oral | hamster | COSMOS_DB |
| 125 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
Showing 50 of 98 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | tert-butyl-4-methoxyphenol | 246-563-8 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
0.07%
Category
antioxidant
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
E320 — ADI: 0.5 mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Butylated hydroxyanisole?
Butylated hydroxyanisole appears on 14 regulatory/inventory lists including drinking_water; Europe; manufacturing; plastic_additive, active_ingredient; Europe; Pesticides, Europe, and 11 more. Source: EPA CPDat.
Is Butylated hydroxyanisole a carcinogen according to IARC?
Butylated hydroxyanisole is classified by IARC as Group 2B — possibly carcinogenic to humans (evaluated 1987). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.
Is Butylated hydroxyanisole on the California Proposition 65 list?
Yes, Butylated hydroxyanisole is listed under California Proposition 65 for cancer. Source: California OEHHA Proposition 65.
Is Butylated hydroxyanisole used in cosmetics?
Yes, Butylated hydroxyanisole is also indexed as a cosmetic ingredient under the name BHA. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Butylated hydroxyanisole come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, ECHA REACH, California Proposition 65, CosIng / Ingredients DB, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Butylated hydroxyanisole have different safety status in cosmetics vs industrial chemicals?
Butylated hydroxyanisole is classified GHS CMR hazard (H302, H315, H319, H335, H351, H361, H361f, H411) in the chemicals database but is restricted in EU cosmetics at max 0.07%.
Is Butylated hydroxyanisole used outside industrial chemicals?
Butylated hydroxyanisole also appears in cosmetics, food safety, cannabis databases.