What is the NOAEL for 5-Chloro-2-methyl-3(2H)-isothiazolone?
5-Chloro-2-methyl-3(2H)-isothiazolone has 100 NOAEL studies in the database. The lowest reported value is 0.009 % via Dermal in Mouse. Source: NTP_ICE_skin_sensitization.
NOAEL Data
Cosmetic Ingredient
5-Chloro-2-methyl-3(2H)-isothiazolone
Also known as: BRN 1210149, EINECS 247-500-7, UNII-DEL7T5QRPN, 2,3-dihydro-2-methyl-3-oxo-5-chloroisothiazole, CMIT (+2 more)
CAS 26172-55-4
5-Chloro-2-methyl-3(2H)-isothiazolone (CAS 26172-55-4) is a chemical substance. Key regulatory status: 59 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.
View cosmetic safety profile for Methylchloroisothiazolinone →
SOURCE
noael studies public
NOAEL studies
100
SOURCE
chemical inventory jurisdictions
Regulatory lists
59
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
13 fields
Name
5-Chloro-2-methyl-3(2H)-isothiazolone
CAS Number
26172-55-4
DTXSID
DTXSID9034286
Molecular Formula
C4H4ClNOS
InChI Key
DHNRXBZYEKSXIM-UHFFFAOYSA-N
Monoisotopic Mass
148.970213
Synonyms
BRN 1210149EINECS 247-500-7UNII-DEL7T5QRPN2,3-dihydro-2-methyl-3-oxo-5-chloroisothiazoleCMITMCIchloromethylisothiazolinone
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
PreservativeAntioxidantBiocideProcessing aids not otherwise specified
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
59 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; Europe | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; Europe | Danish Environmental Protection Agency | Danish EPA |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | California Department of Pesticide Regulation | State of California |
| Cleaning products and household care - shoes; Europe | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - shoes; Europe | Danish Environmental Protection Agency | Danish EPA |
| CEDI | FDA | United States Food and Drug Administration (FDA) |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| detected; Other indirect contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 50 of 100 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 10.2 | % | - | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| =19.6 | mg/kg bw | - | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| =104 | mg/kg/day | - | - | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| =104 | mg/kg/day | - | - | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| =104 | mg/kg/day | - | - | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 96.3 | % | Depletion Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 35.1 | % | Depletion Lys | Dermal | - | NTP_ICE_skin_sensitization |
| 2.3 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| 0.009 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 0.01 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 1 | unitless | EPA Classification | Ocular | Rabbit | NTP_ICE_eye_irritation |
| 1 | unitless | EPA Classification | Ocular | Rabbit | NTP_ICE_eye_irritation |
| 1 | unitless | EPA Classification | Ocular | Rabbit | NTP_ICE_eye_irritation |
| 1 | unitless | EPA Classification | Ocular | Rabbit | NTP_ICE_eye_irritation |
| 2 | unitless | EPA Classification | Inhalation | - | NTP_ICE_acute_inhalation |
| 3 | unitless | EPA Classification | Inhalation | - | NTP_ICE_acute_inhalation |
| 1 | unitless | EPA classification | Dermal | Rabbit | NTP_ICE_skin_irritation |
| 1 | unitless | EPA classification | Dermal | Rabbit | NTP_ICE_skin_irritation |
| 2 | unitless | EPA classification | Dermal | Rat | NTP_ICE_acute_dermal |
| =2 | Unitless | EPA classification | oral | Rat (Female) | NTP_ICE_acute_oral |
| 2 | unitless | EPA classification | Dermal | Rabbit | NTP_ICE_skin_irritation |
| 2 | unitless | EPA classification | Dermal | Rabbit | NTP_ICE_skin_irritation |
| 3 | unitless | EPA classification | Dermal | Rat | NTP_ICE_acute_dermal |
| =3 | Unitless | EPA classification | oral | Rat (Female) | NTP_ICE_acute_oral |
| =3 | Unitless | EPA classification | oral | Rat (Female) | NTP_ICE_acute_oral |
| =3 | Unitless | EPA classification | oral | Rat | NTP_ICE_acute_oral |
| =3 | Unitless | EPA classification | oral | Rat | NTP_ICE_acute_oral |
| =3 | Unitless | EPA classification | oral | Rat (Female) | NTP_ICE_acute_oral |
| 4 | unitless | EPA classification | Dermal | Rat | NTP_ICE_acute_dermal |
| DEL7T5QRPN | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| DEL7T5QRPN | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| DEL7T5QRPN | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| DEL7T5QRPN | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1 | unitless | GHS Classification | Dermal | Guinea pig | NTP_ICE_skin_sensitization |
| 4 | unitless | GHS Classification | Inhalation | - | NTP_ICE_acute_inhalation |
| =4 | Unitless | GHS classification | oral | Rat | NTP_ICE_acute_oral |
| =4 | Unitless | GHS classification | oral | Rat (Female) | NTP_ICE_acute_oral |
| =4 | Unitless | GHS classification | oral | Rat | NTP_ICE_acute_oral |
| =4 | Unitless | GHS classification | oral | Rat (Female) | NTP_ICE_acute_oral |
| =4 | Unitless | GHS classification | oral | Rat (Female) | NTP_ICE_acute_oral |
| 5 | unitless | GHS classification | Dermal | Rat | NTP_ICE_acute_dermal |
| =5 | Unitless | GHS classification | oral | Rat (Female) | NTP_ICE_acute_oral |
| 16.9 | uM | IC50 | Dermal | - | NTP_ICE_skin_sensitization |
| 7.248 | ratio | Imax | Dermal | - | NTP_ICE_skin_sensitization |
| 0.21 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| range0.52 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| 0.73 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| 1.69 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| =1030 | mg/kg bw | LD50 | oral | Rat (Female) | NTP_ICE_acute_oral |
| >2000 | mg/kg | LD50 | Dermal | Rat | NTP_ICE_acute_dermal |
Showing 50 of 100 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
0.0015% in rinse-off cosmetics only as MCI/MI 3:1 blend; prohibited in leave-on cosmetics
Category
preservative
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL1738962
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include 5-Chloro-2-methyl-3(2H)-isothiazolone?
5-Chloro-2-methyl-3(2H)-isothiazolone appears on 22 regulatory/inventory lists including IFRA Transparency, inert_ingredient; non_food_use; Pesticides, Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; Europe, and 19 more. Source: EPA CPDat.
Is 5-Chloro-2-methyl-3(2H)-isothiazolone used in cosmetics?
Yes, 5-Chloro-2-methyl-3(2H)-isothiazolone is also indexed as a cosmetic ingredient under the name Methylchloroisothiazolinone. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 5-Chloro-2-methyl-3(2H)-isothiazolone come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is 5-Chloro-2-methyl-3(2H)-isothiazolone used outside industrial chemicals?
5-Chloro-2-methyl-3(2H)-isothiazolone also appears in cosmetics, pharmaceutical, cannabis databases.