Danger GHS06GHS05GHS09 NOAEL Data REACH Registered Cosmetic Ingredient

1,2-Benzisothiazolin-3-one

Also known as: Benzisothiazolinone, Caswell No. 079A, Caswell No. 513A, EINECS 220-120-9, EPA Pesticide Chemical Code 098901 (+6 more)

CAS 2634-33-5

1,2-Benzisothiazolin-3-one (CAS 2634-33-5) is a chemical substance with GHS signal word Danger; key hazard signal: H330; H302; H315; H318; H317; H400; H410. Key regulatory status: REACH registered, 36 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH.

View cosmetic safety profile for Benzisothiazolinone →

Cross-Vertical Regulatory Divergence

1,2-Benzisothiazolin-3-one is classified GHS Danger (H330, H302, H315, H318, H317, H400, H410) in the chemicals database but is restricted in EU cosmetics at max Permitted in rinse-off cosmetics; restricted or banned in leave-on products.

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status/eu_max; Chemicals: eu_clp_annex_vi.signal_word/hazard_statement_code

SOURCE NOAEL studies

NOAEL studies

SOURCE Chemical inventory jurisdictions

Regulatory lists

SOURCE EU CLP Annex VI

GHS signal

Danger

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 16 fields

Name

1,2-Benzisothiazolin-3-one

CAS Number

2634-33-5

Molecular Formula

C7H5NOS

InChI Key

DMSMPAJRVJJAGA-UHFFFAOYSA-N

Monoisotopic Mass

151.009185

Synonyms

BenzisothiazolinoneCaswell No. 079ACaswell No. 513AEINECS 220-120-9EPA Pesticide Chemical Code 098901UNII-HRA0F1A4R31,2-Benzisothiazoline-3-one2,3-dihydro-3-oxo-1,2-benzisothiazoleBITIPXbenzo[d]isothiazol-3-one

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications

Hazard Class	H-Statements	Pictograms	Signal
Acute Tox. 2; Acute Tox. 4; Skin Irrit. 2; Eye Dam. 1; Skin Sens. 1A; Aquatic Acute 1; Aquatic Chronic 1	H330; H302; H315; H318; H317; H400; H410	GHS06; GHS05; GHS09	Danger

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 60 records

PreservativeAntioxidantBiocideDegradant/impurityProcessing aids not otherwise specified

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 36 records

List	Keyword	Source
fracking; water	NY Department of Conservation	CPCat
consumer_product; Europe	Danish Environmental Protection Agency	Danish EPA
IFRA Transparency	IFRA	IFRA
SCIL (9/2019)	USEPA	Safer Chemical Ingredients List
Europe; Pesticides	Danish EPA	Danish EPA
detected; Europe; Pesticides	Danish EPA	Danish EPA
Indirect additives food contact (10/2018)	FDA	United States Food and Drug Administration (FDA)
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
Europe; Vehicle - car interior	Danish Environmental Protection Agency	Danish EPA
active_ingredient; Europe; Pesticides	Commission of the European Communities	CPCat
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	California Department of Pesticide Regulation	State of California
inert_ingredient; non_food_use; Pesticides	EPA	CPCat

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 76 studies

Value	Unit	Endpoint	Route	Species	Source
52.05	uM	AC50	-	-	NTP ICE endocrine
37.22	uM	ACC	-	-	NTP ICE endocrine
240	min	Breakthrough Time	Dermal	-	NTP ICE skin irritation
0.54	ug/mL	CD54, EC200	Dermal	-	NTP ICE skin sensitization
0.55	ug/mL	CD54, EC200	Dermal	-	NTP ICE skin sensitization
0.39	ug/mL	CD86, EC150	Dermal	-	NTP ICE skin sensitization
0.55	ug/mL	CD86, EC150	Dermal	-	NTP ICE skin sensitization
3.43	ug/mL	CV70	Dermal	-	NTP ICE skin sensitization
1.83	ug/mL	CV75	Dermal	-	NTP ICE skin sensitization
34.74	uL/min/10^6 cells	Clint	-	Human	NTP ICE adme parameters
=6.81	mg/m3	DNEL systemic	inhalation	Human	ToxValDB GESTIS DNEL
97.7	%	Depletion Cys	Dermal	-	NTP ICE skin sensitization
9.7	%	Depletion Lys	Dermal	-	NTP ICE skin sensitization
50	%	Depletion Lys + Cys	Dermal	-	NTP ICE skin sensitization
53.7	%	Depletion Lys + Cys	Dermal	-	NTP ICE skin sensitization
3.156	uM	EC1.5	Dermal	-	NTP ICE skin sensitization
2.3	%	EC3	Dermal	Mouse	NTP ICE skin sensitization
4.8	%	EC3	Dermal	Mouse	NTP ICE skin sensitization
14.77	uM	EC3	Dermal	-	NTP ICE skin sensitization
32.4	%	EC3	Dermal	Mouse	NTP ICE skin sensitization
1	unitless	EPA Classification	Ocular	Rabbit	NTP ICE eye irritation
1	unitless	EPA classification	Dermal	Rabbit	NTP ICE skin irritation
2	unitless	EPA classification	Dermal	Rabbit	NTP ICE skin irritation
3	unitless	EPA classification	Dermal	Rat	NTP ICE acute dermal
=3	Unitless	EPA classification	oral	Rat (Female)	NTP ICE acute oral
=3	Unitless	EPA classification	oral	Rat	NTP ICE acute oral
=3	Unitless	EPA classification	oral	Rat (Male)	NTP ICE acute oral
3	unitless	EPA classification	Dermal	Rabbit	NTP ICE skin irritation
4	unitless	EPA classification	Dermal	Rat	NTP ICE acute dermal
4	unitless	EPA classification	Dermal	Rabbit	NTP ICE skin irritation
HRA0F1A4R3	UNII	FDA UNII substance identifier	-	-	openFDA substances
0	fraction	Fu	-	Human	NTP ICE adme parameters
1	unitless	GHS Classification	Dermal	Guinea pig	NTP ICE skin sensitization
2	unitless	GHS Classification	Inhalation	-	NTP ICE acute inhalation
3	unitless	GHS Classification	Inhalation	-	NTP ICE acute inhalation
=4	Unitless	GHS classification	oral	Rat (Female)	NTP ICE acute oral
=4	Unitless	GHS classification	oral	Rat	NTP ICE acute oral
=4	Unitless	GHS classification	oral	Rat (Male/Female)	NTP ICE acute oral
5	unitless	GHS classification	Dermal	Rat	NTP ICE acute dermal
=5	Unitless	GHS classification	oral	Rat (Male)	NTP ICE acute oral
=5	Unitless	GHS classification	oral	Rat (Female)	NTP ICE acute oral
50.87	uM	IC50	Dermal	-	NTP ICE skin sensitization
23.96	ratio	Imax	Dermal	-	NTP ICE skin sensitization
>0.5	mg/L	LC50	Inhalation	-	NTP ICE acute inhalation
0.73	mg/L	LC50	Inhalation	-	NTP ICE acute inhalation
=1020	mg/kg bw	LD50	oral	Rat	NTP ICE acute oral
=1030	mg/kg bw	LD50	oral	Rat (Female)	NTP ICE acute oral
=1050	mg/kg bw	LD50	oral	Rat (Female)	NTP ICE acute oral
=1367	mg/kg bw	LD50	oral	Rat (Female)	NTP ICE acute oral
=1450	mg/kg bw	LD50	oral	Rat (Male/Female)	NTP ICE acute oral

Showing 50 of 76 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA 1 records

Status	Name	EC Number	Link
Registered	1,2-benzisothiazol-3(2H)-one	220-120-9	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE SCCS Opinion 1 opinions

Opinion	Date	Conclusion	Max Conc.	Concerns
SCCS/1473/12	26-27 June 2012	Safe — safe as preservative at 0.01% in cosmetic products	0.01% in all cosmetic products	Skin sensitisation (moderate contact allergen potential); skin and eye irritation; risk acceptable at 0.01%

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

restricted

Max

Permitted in rinse-off cosmetics; restricted or banned in leave-on products

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE ChEMBL / DailyMed CHEMBL297304

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the GHS hazard classification for 1,2-Benzisothiazolin-3-one?

1,2-Benzisothiazolin-3-one (CAS 2634-33-5) is classified under EU CLP Annex VI as Acute Tox. 2; Acute Tox. 4; Skin Irrit. 2; Eye Dam. 1; Skin Sens. 1A; Aquatic Acute 1; Aquatic Chronic 1 with signal word Danger. Hazard statements: H330; H302; H315; H318; H317; H400; H410. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for 1,2-Benzisothiazolin-3-one?

1,2-Benzisothiazolin-3-one has 76 NOAEL studies in the database. The lowest reported value is 0 fraction in Human. Source: NTP ICE adme parameters.

What regulatory lists include 1,2-Benzisothiazolin-3-one?

1,2-Benzisothiazolin-3-one appears on 11 regulatory/inventory lists including fracking; water, consumer_product; Europe, IFRA Transparency, and 8 more. Source: EPA CPDat.

Is 1,2-Benzisothiazolin-3-one used in cosmetics?

Yes, 1,2-Benzisothiazolin-3-one is also indexed as a cosmetic ingredient under the name Benzisothiazolinone. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 1,2-Benzisothiazolin-3-one come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does 1,2-Benzisothiazolin-3-one have different safety status in cosmetics vs industrial chemicals?

Is 1,2-Benzisothiazolin-3-one used outside industrial chemicals?

1,2-Benzisothiazolin-3-one also appears in cosmetics, pharmaceutical, cannabis databases.