Danger GHS06GHS05GHS09 NOAEL Data REACH Registered Cosmetic Ingredient

Octhilinone

Also known as: 2-Octyl-3-isothiazolone, BRN 1211137, Caswell No. 613C, EINECS 247-761-7, EPA Pesticide Chemical Code 099901 (+8 more)

CAS 26530-20-1

Octhilinone (CAS 26530-20-1) is a chemical substance with GHS signal word Danger; key hazard signal: H330; H311; H301; H314; H318; H317; H400; H410. Key regulatory status: REACH registered, 34 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for OCTYLISOTHIAZOLINONE →

Cross-Vertical Regulatory Divergence

Octhilinone is classified GHS Danger (H330, H311, H301, H314, H318, H317, H400, H410) in the chemicals database but is allowed in EU cosmetics.

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: eu_clp_annex_vi.signal_word/hazard_statement_code

SOURCE NOAEL studies

NOAEL studies

SOURCE Chemical inventory jurisdictions

Regulatory lists

SOURCE EU CLP Annex VI

GHS signal

Danger

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 19 fields

Name

Octhilinone

CAS Number

26530-20-1

DTXSID

DTXSID1025805

Molecular Formula

C11H19NOS

InChI Key

JPMIIZHYYWMHDT-UHFFFAOYSA-N

Monoisotopic Mass

213.118735

Synonyms

2-Octyl-3-isothiazoloneBRN 1211137Caswell No. 613CEINECS 247-761-7EPA Pesticide Chemical Code 099901Microbicide M-8Micro-chek skanePancil-TVinylzene IT 3000DIDPUNII-4LFS24GD0V2-Octyl-3-isothioazoloneOctyl-3(2H)-isothiazolone

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications

Hazard Class	H-Statements	Pictograms	Signal
Acute Tox. 2; Acute Tox. 3; Acute Tox. 3; Skin Corr. 1; Eye Dam. 1; Skin Sens. 1A; Aquatic Acute 1; Aquatic Chronic 1	H330; H311; H301; H314; H318; H317; H400; H410	GHS06; GHS05; GHS09	Danger

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 60 records

PreservativeBiocideAntioxidant

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 34 records

List	Keyword	Source
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Europe; Pesticides	Commission of the European Communities	CPCat
SCIL (9/2019)	USEPA	Safer Chemical Ingredients List
Europe; nondetect; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	California Department of Pesticide Regulation	State of California
active_ingredient; Europe; Pesticides	European Commission	CPCat
active_ingredient; Australia	Australian Pesticides and Veterinary Medicines Authority	CPCat
Pesticides; residue	FDA	United States Food and Drug Administration (FDA)
Pesticides; residue	FDA	United States Food and Drug Administration (FDA)
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 77 studies

Value	Unit	Endpoint	Route	Species	Source
14.525441368998	uM	AC50	-	-	NTP ICE endocrine
12.33017214	uM	ACC	-	-	NTP ICE endocrine
12.72	uL/min/10^6 cells	Clint	-	Human	NTP ICE adme parameters
1	unitless	EPA Classification	Ocular	Rabbit	NTP ICE eye irritation
2	unitless	EPA Classification	Inhalation	-	NTP ICE acute inhalation
3	unitless	EPA Classification	Inhalation	-	NTP ICE acute inhalation
3	unitless	EPA Classification	Ocular	Rabbit	NTP ICE eye irritation
4	unitless	EPA Classification	Inhalation	-	NTP ICE acute inhalation
1	unitless	EPA classification	Dermal	Rabbit	NTP ICE skin irritation
=2	Unitless	EPA classification	oral	Rat (Female)	NTP ICE acute oral
3	unitless	EPA classification	Dermal	Rat	NTP ICE acute dermal
=3	Unitless	EPA classification	oral	Rat (Female)	NTP ICE acute oral
=3	Unitless	EPA classification	oral	Rat (Female)	NTP ICE acute oral
3	unitless	EPA classification	Dermal	Rabbit	NTP ICE skin irritation
4	unitless	EPA classification	Dermal	Rat	NTP ICE acute dermal
4LFS24GD0V	UNII	FDA UNII substance identifier	-	-	openFDA substances
4LFS24GD0V	UNII	FDA UNII substance identifier	-	-	openFDA substances
4LFS24GD0V	UNII	FDA UNII substance identifier	-	-	openFDA substances
4LFS24GD0V	UNII	FDA UNII substance identifier	-	-	openFDA substances
0.02822	fraction	Fu	-	Human	NTP ICE adme parameters
1	unitless	GHS Classification	Dermal	Guinea pig	NTP ICE skin sensitization
=3	Unitless	GHS classification	oral	Rat (Female)	NTP ICE acute oral
5	unitless	GHS classification	Dermal	Rat	NTP ICE acute dermal
=5	Unitless	GHS classification	oral	Rat (Female)	NTP ICE acute oral
=5	Unitless	GHS classification	oral	Rat (Female)	NTP ICE acute oral
0.38	mg/L	LC50	Inhalation	-	NTP ICE acute inhalation
range0.51	mg/L	LC50	Inhalation	-	NTP ICE acute inhalation
>2.07	mg/L	LC50	Inhalation	-	NTP ICE acute inhalation
=97	mg/kg bw	LD50	oral	Rat (Female)	NTP ICE acute oral
=550	mg/kg bw	LD50	oral	Rat	NTP ICE acute oral
>2000	mg/kg	LD50	Dermal	Rat	NTP ICE acute dermal
>2000	mg/kg bw	LD50	oral	Rat (Female)	NTP ICE acute oral
=3129	mg/kg bw	LD50	oral	Rat (Female)	NTP ICE acute oral
>5000	mg/kg	LD50	Dermal	Rat	NTP ICE acute dermal
=0.0365	mg/kg bw/day	LEL	inhalation	Rat	ToxValDB ToxRefDB
=0.0365	mg/kg bw/day	LEL	inhalation	rat (sprague dawley; Sprague Dawley (CD))	EPA ToxRefDB v3
=30	mg/kg bw/day	LEL	oral	Rat	ToxValDB ToxRefDB
=30	mg/kg bw/day	LEL	oral	rat	EPA ToxRefDB v3
=80	mg/kg bw/day	LEL	oral	Rabbit	ToxValDB ToxRefDB
=80	mg/kg bw/day	LEL	oral	rabbit (new zealand white; New Zealand White)	EPA ToxRefDB v3
=96	mg/kg bw/day	LEL	oral	Rat	ToxValDB ToxRefDB
=96	mg/kg bw/day	LEL	oral	rat (wistar; Wistar (BR))	EPA ToxRefDB v3
=107	mg/kg bw/day	LEL	oral	Rat	ToxValDB ToxRefDB
=107	mg/kg bw/day	LEL	oral	rat (wistar; Wistar (BR))	EPA ToxRefDB v3
=111	mg/kg bw/day	LEL	oral	Rat	ToxValDB ToxRefDB
=111	mg/kg bw/day	LEL	oral	rat (wistar; Wistar (BR))	EPA ToxRefDB v3
=120	mg/kg bw/day	LEL	oral	Rat	ToxValDB ToxRefDB
=120	mg/kg bw/day	LEL	oral	rat (wistar; Wistar (BR))	EPA ToxRefDB v3
80	mg/kg bw/day	LOEL	Oral	Rabbit	NTP ICE dart
80	mg/kg bw/day	LOEL	Oral	Rabbit	NTP ICE dart

Showing 50 of 77 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA 1 records

Status	Name	EC Number	Link
Registered	octhilinone (ISO); 2-octyl-2H-isothiazol-3-one	247-761-7	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE ChEMBL / DailyMed CHEMBL1562104

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Frequently Asked Questions

What is the GHS hazard classification for Octhilinone?

Octhilinone (CAS 26530-20-1) is classified under EU CLP Annex VI as Acute Tox. 2; Acute Tox. 3; Acute Tox. 3; Skin Corr. 1; Eye Dam. 1; Skin Sens. 1A; Aquatic Acute 1; Aquatic Chronic 1 with signal word Danger. Hazard statements: H330; H311; H301; H314; H318; H317; H400; H410. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for Octhilinone?

Octhilinone has 77 NOAEL studies in the database. The lowest reported value is 0 unitless. Source: NTP ICE endocrine.

What regulatory lists include Octhilinone?

Octhilinone appears on 6 regulatory/inventory lists including active_ingredient; Pesticides, active_ingredient; Europe; Pesticides, SCIL (9/2019), and 3 more. Source: EPA CPDat.

Is Octhilinone used in cosmetics?

Yes, Octhilinone is also indexed as a cosmetic ingredient under the name OCTYLISOTHIAZOLINONE. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Octhilinone come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Does Octhilinone have different safety status in cosmetics vs industrial chemicals?

Octhilinone is classified GHS Danger (H330, H311, H301, H314, H318, H317, H400, H410) in the chemicals database but is allowed in EU cosmetics.

Is Octhilinone used outside industrial chemicals?

Octhilinone also appears in cosmetics, pharmaceutical databases.