What is the NOAEL for Ensulizole?
Ensulizole has 17 NOAEL studies in the database. The lowest reported value is 0.125 mg/kg via oral in rat. Source: SCCS Opinion.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Ensulizole
Also known as: 2-Phenyl-1H-benzimidazole-5-sulfonic acid, EINECS 248-502-0, UNII-9YQ9DI1W42
CAS 27503-81-7
Ensulizole (CAS 27503-81-7) is a chemical substance. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH.
SOURCE
NOAEL studies
NOAEL studies
17
SOURCE
Chemical inventory jurisdictions
Regulatory lists
4
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
8 fields
Name
Ensulizole
CAS Number
27503-81-7
Molecular Formula
C13H10N2O3S
InChI Key
UVCJGUGAGLDPAA-UHFFFAOYSA-N
Monoisotopic Mass
274.041213
Synonyms
2-Phenyl-1H-benzimidazole-5-sulfonic acidEINECS 248-502-0UNII-9YQ9DI1W42
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
12 records
UV stabilizerFragrance
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; consumer_product; Substances in Products - Canada (4/2014) | Government of Canada | CPCat |
| IFRA Transparency | IFRA | IFRA |
| Europe; Personal care | European Commission | CosIng |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 17 of 17 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 200 | mg/kg bw | - | oral | rat | Regulatory source |
| 1000 | mg/kg bw | - | oral | rat | Regulatory source |
| 1000 | mg/kg bw/day | - | oral | rat | Regulatory source |
| =7 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| 9YQ9DI1W42 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =0.125 | mg/kg | NOAEL | oral | rat | SCCS Opinion |
| =4 | % | NOAEL | oral | rat | SCCS Opinion |
| =40 | mg/kg bw | NOAEL | oral | rat | SCCS Opinion |
| =200 | mg/kg bw | NOAEL | oral | rat | SCCS Opinion |
| 1000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| =1000 | mg/kg bw/day | NOAEL | - | - | SCCS Opinion |
| =1000 | mg/kg bw | NOAEL | oral | rat | SCCS Opinion |
| =0.125 | mg/kg | dermal absorption | oral | rat | Regulatory source |
| 4 | % | dermal absorption | oral | rat | Regulatory source |
| =40 | mg/kg bw | dermal absorption | oral | rat | Regulatory source |
| 200 | mg/kg bw | dermal absorption | oral | rat | Regulatory source |
| 1000 | mg/kg bw/day | genotoxicity | - | - | Regulatory source |
Showing 17 of 17 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2-phenyl-1H-benzimidazole-5-sulphonic acid | 248-502-0 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
SCCS Opinions
EU Scientific Committee opinions tied to the matched substance.
SOURCE
SCCS Opinion
1 opinions
| Opinion | Date | Conclusion | Max Conc. | Concerns |
|---|---|---|---|---|
| SCCP/1056/06 | 2006-12-19 | Based on the information provided, the SCCP is of the opinion that the use of phenylbenzimidazole sulfonic acid and its salts as a UV-filter at a maximum concentration of 8.0% in the cosmetic sun protection preparations does not pose a risk to the health of the consumer. Uses of phenylbenzimidazole sulfonic acid and its salts in other types of cosmetic products at concentrations up to 8.0% also does not pose a risk to the health of the consumer. | 8.0% | None preventing safe use; assessed as UV filter (COLIPA S45). |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
4%
Category
active
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
ENSULIZOLE
ChEMBL Phase
2
Adverse Events
0
Bioactivity
3
Frequently Asked Questions
What regulatory lists include Ensulizole?
Ensulizole appears on 4 regulatory/inventory lists including Canada; pharmaceutical, Canada; consumer_product; Substances in Products - Canada (4/2014), IFRA Transparency, and 1 more. Source: EPA CPDat.
Is Ensulizole used in cosmetics?
Yes, Ensulizole is also indexed as a cosmetic ingredient under the name Ensulizole. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Ensulizole come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is Ensulizole used outside industrial chemicals?
Ensulizole also appears in cosmetics, pharmaceutical databases.