NOAEL Data REACH Registered Cosmetic Ingredient

4-Amino-m-cresol

Also known as: Phenol, 4-amino-3-methyl-, BRN 2078803, EINECS 220-621-2, NSC 72170, UNII-12R07I1K8C (+11 more)

CAS 2835-99-6

4-Amino-m-cresol (CAS 2835-99-6) is a chemical substance. Key regulatory status: REACH registered, 6 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH.

View cosmetic safety profile for 4-Amino-M-Cresol →

Cross-Vertical Regulatory Divergence

4-Amino-m-cresol is prohibited in EU cosmetics at max 1.5% but has active industrial GHS classifications (H302, H315, H317, H319, H335, H400, H410).

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 22 fields

Name

4-Amino-m-cresol

CAS Number

2835-99-6

DTXSID

DTXSID2049262

Molecular Formula

C7H9NO

InChI Key

QGNGOGOOPUYKMC-UHFFFAOYSA-N

Monoisotopic Mass

123.068414

Synonyms

Phenol, 4-amino-3-methyl-BRN 2078803EINECS 220-621-2NSC 72170UNII-12R07I1K8C2-Amino-5-hydroxytoluene2-Methyl-4-hydroxyaniline3-Methyl-4-aminophenol4-Amino-3-methylphenol4-Hydroxy-2-methylaniline4-Hydroxy-o-toluidine4-OH-6'-methylalanine

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 4 records

Dye

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 6 records

List	Keyword	Source
Europe; Personal care; restricted	European Commission	CosIng
Canada; Personal care; Substances in PCP - Canada (4/2014)	Government of Canada	CPCat
Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA
Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA
Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA
Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 21 of 21 studies

Value	Unit	Endpoint	Route	Species	Source
1.03	ug/mL	CD86, EC150	Dermal	-	NTP_ICE_skin_sensitization
=1.5	mg/m3	DNEL systemic	inhalation	Human	ToxValDB_GESTIS_DNEL
90	%	Depletion Cys	Dermal	-	NTP_ICE_skin_sensitization
28.8	%	Depletion Lys	Dermal	-	NTP_ICE_skin_sensitization
5.278	uM	EC1.5	Dermal	-	NTP_ICE_skin_sensitization
1.5	%	EC3	Dermal	Mouse	NTP_ICE_skin_sensitization
12R07I1K8C	UNII	FDA UNII substance identifier	-	-	openFDA substances
12R07I1K8C	UNII	FDA UNII substance identifier	-	-	openFDA substances
12R07I1K8C	UNII	FDA UNII substance identifier	-	-	openFDA substances
12R07I1K8C	UNII	FDA UNII substance identifier	-	-	openFDA substances
77.67	uM	IC50	Dermal	-	NTP_ICE_skin_sensitization
7.609	ratio	Imax	Dermal	-	NTP_ICE_skin_sensitization
120	mg/kg bw/day	LOAEL	oral	rat	COSMOS_DB
60	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB
=60	mg/kg	NOAEL	oral	rat	SCCS_vision_codex
=60	mg/kg	NOAEL	oral	rat	SCCS_vision_codex
=60	mg/kg	NOAEL	oral	rat	SCCS_vision_codex
=60	mg/kg	NOAEL	oral	rat	SCCS_vision_codex
=60	mg/kg	repeated dose toxicity	oral	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
=60	mg/kg	repeated dose toxicity	oral	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
60	mg/kg bw/day	repeated dose toxicity	oral	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies

Showing 21 of 21 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	4-amino-m-cresol	220-621-2	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE EU SCCS 1 opinions

Opinion	Date	Conclusion	Max Conc.	Concerns
SCCP/0874/05	20 September 2005	safe	1.5%	strong sensitiser; MoS adequate

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

prohibited

Max

1.5%

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL CHEMBL3092390

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Frequently Asked Questions

What is the NOAEL for 4-Amino-m-cresol?

4-Amino-m-cresol has 21 NOAEL studies in the database. The lowest reported value is 1.03 ug/mL via Dermal. Source: NTP_ICE_skin_sensitization.

What regulatory lists include 4-Amino-m-cresol?

4-Amino-m-cresol appears on 3 regulatory/inventory lists including Europe; Personal care; restricted, Canada; Personal care; Substances in PCP - Canada (4/2014), Europe; Personal care - hair coloring. Source: EPA CPDat.

Is 4-Amino-m-cresol used in cosmetics?

Yes, 4-Amino-m-cresol is also indexed as a cosmetic ingredient under the name 4-Amino-M-Cresol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 4-Amino-m-cresol come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Does 4-Amino-m-cresol have different safety status in cosmetics vs industrial chemicals?

4-Amino-m-cresol is prohibited in EU cosmetics at max 1.5% but has active industrial GHS classifications (H302, H315, H317, H319, H335, H400, H410).

Is 4-Amino-m-cresol used outside industrial chemicals?

4-Amino-m-cresol also appears in cosmetics, pharmaceutical databases.