What is the NOAEL for Neopentyl glycol bis(2-ethylhexanoate)?
Neopentyl glycol bis(2-ethylhexanoate) has 5 NOAEL studies in the database. The lowest reported value is 2.906 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Neopentyl glycol bis(2-ethylhexanoate)
Also known as: 2,2-Dimethylpropane-1,3-diyl bis(2-ethylhexanoate), Hexanoic acid, 2-ethyl-, 1,1'-(2,2-dimethyl-1,3-propanediyl) ester, Hexanoic acid, 2-ethyl-, 2,2-dimethyltrimethylene ester, 1,3-Propanediol, 2,2-dimethyl-, bis(2-ethylhexanoate), Cosmol 525 (+15 more)
CAS 28510-23-8
Neopentyl glycol bis(2-ethylhexanoate) (CAS 28510-23-8) is a chemical substance. Key regulatory status: REACH registered, 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
View cosmetic safety profile for NEOPENTYL GLYCOL DIETHYLHEXANOATE →
SOURCE
noael studies public
NOAEL studies
5
SOURCE
chemical inventory jurisdictions
Regulatory lists
1
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
Neopentyl glycol bis(2-ethylhexanoate)
CAS Number
28510-23-8
DTXSID
DTXSID20865431
Molecular Formula
C21H40O4
InChI Key
GORMSINSWZJIKL-UHFFFAOYSA-N
Monoisotopic Mass
356.29266
Synonyms
2,2-Dimethylpropane-1,3-diyl bis(2-ethylhexanoate)Hexanoic acid, 2-ethyl-, 1,1'-(2,2-dimethyl-1,3-propanediyl) esterHexanoic acid, 2-ethyl-, 2,2-dimethyltrimethylene ester1,3-Propanediol, 2,2-dimethyl-, bis(2-ethylhexanoate)Cosmol 525KAK-NDOHexanoic acid, 2-ethyl-, 2,2-dimethyl-1,3-propanediyl esterNeopentyl glycol diethylhexanoateNeopentylglycol di-2-ethylhexanoateNissan Unister H 208BRSSchercemol NGDOUnister H 208BRS
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
6 records
Softener and conditionerThickening agent
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
1 records
| List | Keyword | Source |
|---|---|---|
| Canada; Personal care; Substances in PCP - Canada (4/2014) | Government of Canada | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 5 of 5 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =2.906 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| U68ZV6W62C | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| U68ZV6W62C | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| U68ZV6W62C | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| U68ZV6W62C | UNII | FDA UNII substance identifier | - | - | openFDA substances |
Showing 5 of 5 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2,2-dimethylpropane-1,3-diyl 2-ethylhexanoate | 249-060-1 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Emollient
Frequently Asked Questions
What regulatory lists include Neopentyl glycol bis(2-ethylhexanoate)?
Neopentyl glycol bis(2-ethylhexanoate) appears on 1 regulatory/inventory list including Canada; Personal care; Substances in PCP - Canada (4/2014). Source: EPA CPDat.
Is Neopentyl glycol bis(2-ethylhexanoate) used in cosmetics?
Yes, Neopentyl glycol bis(2-ethylhexanoate) is also indexed as a cosmetic ingredient under the name NEOPENTYL GLYCOL DIETHYLHEXANOATE. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Neopentyl glycol bis(2-ethylhexanoate) come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
Is Neopentyl glycol bis(2-ethylhexanoate) used outside industrial chemicals?
Neopentyl glycol bis(2-ethylhexanoate) also appears in cosmetics databases.