What is the GHS hazard classification for Imidazole?
Imidazole (CAS 288-32-4) is classified under EU CLP Annex VI as Repr. 1B; Acute Tox. 4; Skin Corr. 1C with signal word Danger. Hazard statements: H360D; H302; H314. Source: EU CLP Annex VI (ECHA).
Danger
GHS08GHS07GHS05
NOAEL Data
REACH Registered
Cosmetic Ingredient
Imidazole
Also known as: 1H-Imidazole, 5-23-04-00191, BRN 0103853, EINECS 206-019-2, Formamidine, N,N'-vinylene- (+13 more)
CAS 288-32-4
Imidazole (CAS 288-32-4) is a chemical substance with GHS signal word Danger; key hazard signal: H360D; H302; H314. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.
Cross-Vertical Regulatory Divergence
Imidazole is prohibited in EU cosmetics but has active industrial GHS classifications (H360D, H302, H314).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: eu_clp_annex_vi.signal_word/hazard_statement_code
SOURCE
NOAEL studies
NOAEL studies
14
SOURCE
Chemical inventory jurisdictions
Regulatory lists
3
SOURCE
EU CLP Annex VI
GHS signal
Danger
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
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DSSTox identifiers
23 fields
Name
Imidazole
CAS Number
288-32-4
Molecular Formula
C3H4N2
InChI Key
RAXXELZNTBOGNW-UHFFFAOYSA-N
Monoisotopic Mass
68.037448
Synonyms
1H-Imidazole5-23-04-00191BRN 0103853EINECS 206-019-2Formamidine, N,N'-vinylene-USAF EK-4733NSC 51860GlioksalUNII-7GBN705NH1HimIMDImutex
GHS / CLP Classification
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
SOURCE
EU CLP Annex VI (ECHA)
1 classifications
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Repr. 1B; Acute Tox. 4; Skin Corr. 1C | H360D; H302; H314 | GHS08; GHS07; GHS05 | Danger |
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
WHO/JECFA
1 records
| Field | Value |
|---|---|
| GHS Signal Word | DANGER |
| GHS Hazard Statements | Harmful if swallowed Causes severe skin burns and eye damage Suspected of damaging fertility or the unborn child |
| Short-term Effects | The substance is corrosive to the skin. The substance is severely irritating to the eyes. The substance is irritating to the respiratory tract. |
| Long-term Effects | Animal tests show that this substance possibly causes toxicity to human reproduction or development. |
| Routes of Exposure | The substance can be absorbed into the body by ingestion. |
Functional Uses
Industrial and product-use categories associated with this substance.
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EPA CPDat
5 records
pH regulating agentCatalystHardenerChemical reaction regulator
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| banned; Europe; Personal care | European Commission | CosIng |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 14 of 14 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =10.6 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| 59.3 | unitless | Draize rabbit irritation score | Ocular | Rabbit | NTP ICE eye irritation |
| 1 | unitless | EPA Classification | Ocular | Rabbit | NTP ICE eye irritation |
| 7GBN705NH1 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.26 | %/sec | Intensity | Ocular | - | NTP ICE eye irritation |
| =220 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =30 | mg/L | LOEL | environmental | Mouse | ToxValDB ECOTOX |
| 100 | s | Lag time | Ocular | - | NTP ICE eye irritation |
| 0 | unitless | Model Score | - | - | NTP ICE endocrine |
| =60 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB HESS |
| =30 | mg/L | NOEL | environmental | Mouse | ToxValDB ECOTOX |
| =60 | mg/L | NOEL | environmental | Rat | ToxValDB ECOTOX |
| =210 | mg/L | NOEL | environmental | Rat | ToxValDB ECOTOX |
| 22 | % | Plateau level | Ocular | - | NTP ICE eye irritation |
Showing 14 of 14 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Imidazole | 206-019-2 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Cosmetic Ingredient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
IMIDAZOLE
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
3
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What is the NOAEL for Imidazole?
Imidazole has 14 NOAEL studies in the database. The lowest reported value is 0 unitless. Source: NTP ICE endocrine.
What regulatory lists include Imidazole?
Imidazole appears on 2 regulatory/inventory lists including Canada; pharmaceutical, banned; Europe; Personal care. Source: EPA CPDat.
Is Imidazole used in cosmetics?
Yes, Imidazole is also indexed as a cosmetic ingredient under the name Imidazole. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Imidazole come from?
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Imidazole have different safety status in cosmetics vs industrial chemicals?
Imidazole is prohibited in EU cosmetics but has active industrial GHS classifications (H360D, H302, H314).
Is Imidazole used outside industrial chemicals?
Imidazole also appears in cosmetics, pharmaceutical, cannabis databases.