Also known as: Lead(2+) acetate), Plumbous acetate, Acetic acid, lead(2+) salt, Acetic acid, lead(2 +) salt, Acetic acid lead(2+) salt (+7 more)
CAS 301-04-2
Lead(II) acetate (CAS 301-04-2) is a chemical substance with GHS signal word Danger; key hazard signal: H360Df; H373 **; H400; H410. Key regulatory status: SVHC Candidate List, California Proposition 65, REACH registered, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, AICIS, ECHA REACH, ECHA SVHC, CA Prop 65, ILO ICSC.
Lead(II) acetate is prohibited in EU cosmetics but has active industrial GHS classifications (H360Df, H373, H400, H410).
CAS, identifiers, formula, and alternate names for the matched substance record.
Candidate List status and reason under the ECHA REACH SVHC program.
| Substance | Reason | Included |
|---|---|---|
| Lead di(acetate) | Toxic for reproduction (Article 57c) | 16-Dec-2013 |
California OEHHA listing status and toxicity category.
| Chemical | Toxicity Type | Cancer | Developmental | Listed |
|---|---|---|---|---|
| - | cancer | Yes | No | - |
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Repr. 1A; STOT RE 2 *; Aquatic Acute 1; Aquatic Chronic 1 | H360Df; H373 **; H400; H410 | GHS08; GHS09 | Danger |
International Chemical Safety Card hazard and exposure summary.
| Field | Value |
|---|---|
| GHS Signal Word | DANGER |
| GHS Hazard Statements | Suspected of causing cancer May damage fertility or the unborn child May cause damage to organs through prolonged or repeated exposure Very toxic to aquatic life with long lasting effects |
| Short-term Effects | The substance is irritating to the eyes. The substance may cause effects on the blood and central nervous system. This may result in haemolytic anaemia, nervous disorders and kidney impairment. The effects may be delayed. Medical observation is indicated. |
| Long-term Effects | The substance may have effects on the blood, bone marrow, cardiovascular system, kidneys and nervous system. This may result in anaemia, increase of blood pressure, paralysis, kidney impairment and behavioural effects. This substance is possibly carcinogenic to humans. Causes serious reproductive toxicity in humans. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation and by ingestion. |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| SQEoral=23 | ug/day | California Proposition 65 NSRL | - | - | California Proposition 65 |
| SQEoral=23 | ug/day | California Proposition 65 NSRL | - | - | California Proposition 65 |
| SQEoral=23 | ug/day | California Proposition 65 NSRL | - | - | California Proposition 65 |
| SQEoral=23 | ug/day | California Proposition 65 NSRL | - | - | California Proposition 65 |
| SQEcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| SQEcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| SQEcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| SQEcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| KL498O6790 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| KL498O6790 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| KL498O6790 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| KL498O6790 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =0.32 | mg/kg bw/day | LOEC | oral | Dog | ToxValDB_ECOTOX |
| =1.14 | mg/kg bw/day | LOEC | oral | Dog | ToxValDB_ECOTOX |
| =3.1 | mg/kg bw/day | LOEC | oral | Dog | ToxValDB_ECOTOX |
| =4.836 | mg/kg bw/day | LOEC | oral | Rat | ToxValDB_ECOTOX |
| =88.14 | mg/kg bw/day | LOEC | oral | Rat | ToxValDB_ECOTOX |
| =51.3 | mg/kg bw/day | LOEL | injection | Mouse | ToxValDB_ECOTOX |
| =250 | ppm | LOEL | oral | Rat | ToxValDB_ECOTOX |
| =1.404 | mg/kg bw/day | NOEC | oral | Rat | ToxValDB_ECOTOX |
| =10.998 | mg/kg bw/day | NOEC | oral | Rat | ToxValDB_ECOTOX |
| =11.52 | mg/kg bw/day | NOEC | oral | Dog | ToxValDB_ECOTOX |
| =42.744 | mg/kg bw/day | NOEC | oral | Rat | ToxValDB_ECOTOX |
| =163.956 | mg/kg bw/day | NOEC | oral | Rat | ToxValDB_ECOTOX |
| =15 | mg/L | NOEL | oral | Rat | ToxValDB_ECOTOX |
| =30 | mg/L | NOEL | oral | Rat | ToxValDB_ECOTOX |
| =60 | mg/L | NOEL | oral | Rat | ToxValDB_ECOTOX |
| =200 | mg/L | NOEL | oral | Mouse | ToxValDB_ECOTOX |
| =1000 | mg/L | NOEL | oral | Rat | ToxValDB_ECOTOX |
Showing 29 of 29 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Lead di(acetate) | 206-104-4 | ECHA overview → |
Australian industrial chemicals inventory status and applicable conditions.
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS food additive, ADI, and GRAS records where available.
1 food-safety record found.
View full food safety profile →Lead(II) acetate (CAS 301-04-2) is classified under EU CLP Annex VI as Repr. 1A; STOT RE 2 *; Aquatic Acute 1; Aquatic Chronic 1 with signal word Danger. Hazard statements: H360Df; H373 **; H400; H410. Source: EU CLP Annex VI (ECHA).
Lead(II) acetate has 29 NOAEL studies in the database. The lowest reported value is oral=23 ug/day. Source: California Proposition 65.
Yes, Lead(II) acetate is listed under California Proposition 65 for cancer. Source: California OEHHA Proposition 65.
Yes, Lead(II) acetate is listed on the ECHA REACH Candidate List as a Substance of Very High Concern. Reason: Toxic for reproduction (Article 57c). Source: ECHA SVHC Candidate List.
Yes, Lead(II) acetate is also indexed as a cosmetic ingredient under the name Lead Acetate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ECHA SVHC Candidate List, California Proposition 65, ILO/WHO ICSC, CosIng / Ingredients DB, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.
Lead(II) acetate is prohibited in EU cosmetics but has active industrial GHS classifications (H360Df, H373, H400, H410).
Lead(II) acetate also appears in cosmetics, food safety databases.