What is the NOAEL for 3,4-Dihydroxycinnamic acid?
3,4-Dihydroxycinnamic acid has 9 NOAEL studies in the database. The lowest reported value is cancer listing type. Source: California Proposition 65.
NOAEL Data
IARC Group 2B
Prop 65
Cosmetic Ingredient
3,4-Dihydroxycinnamic acid
Also known as: Caffeic Acid, Cinnamic acid, 3,4-dihydroxy-, 2-Propenoic acid, 3-(3,4-dihydroxyphenyl)-, 3-(3,4-Dihydroxy phenyl)-2-propenoic acid, EINECS 206-361-2 (+1 more)
CAS 331-39-5
3,4-Dihydroxycinnamic acid (CAS 331-39-5) is a chemical substance; key hazard signal: IARC Group 2B. Key regulatory status: California Proposition 65, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, IARC, CA Prop 65.
Cross-Vertical Regulatory Divergence
3,4-Dihydroxycinnamic acid is classified GHS CMR hazard (H315, H319, H335, H351, H361) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
9
SOURCE
chemical inventory jurisdictions
Regulatory lists
2
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
12 fields
Name
3,4-Dihydroxycinnamic acid
CAS Number
331-39-5
DTXSID
DTXSID5020231
Molecular Formula
C9H8O4
InChI Key
QAIPRVGONGVQAS-UHFFFAOYSA-N
Monoisotopic Mass
180.042259
Synonyms
Caffeic AcidCinnamic acid, 3,4-dihydroxy-2-Propenoic acid, 3-(3,4-dihydroxyphenyl)-3-(3,4-Dihydroxy phenyl)-2-propenoic acidEINECS 206-361-2UNII-U2S3A33KVM
IARC Carcinogen Classification
Carcinogenic hazard classification from IARC monograph evaluations.
SOURCE
IARC Monographs on the Identification of Carcinogenic Hazards to Humans
1 records
| Group | Meaning | Evaluated | Volume |
|---|---|---|---|
| Group 2B | Possibly carcinogenic | 1992 | 56 |
California Proposition 65
California OEHHA listing status and toxicity category.
SOURCE
California OEHHA Proposition 65 List
1 records
| Chemical | Toxicity Type | Cancer | Developmental | Listed |
|---|---|---|---|---|
| - | cancer | Yes | No | - |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
2 records
AntioxidantDeodorizer
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
2 records
| List | Keyword | Source |
|---|---|---|
| OEHHA Proposition 65 (3/2019) | STATE OF CALIFORNIA ENVIRONMENTAL PROTECTION AGENCY | OEHHA Proposition 65 List |
| OEHHA Proposition 65 (1/2023) | California Office of Environmental Health Hazard Assessment | OEHHA Proposition 65 List |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 9 of 9 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| ABcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| ABcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| ABcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| U2S3A33KVM | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| U2S3A33KVM | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| U2S3A33KVM | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| U2S3A33KVM | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2B | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 2 | unitless | IARC group | - | - | NTP_ICE_cancer |
Showing 9 of 9 studies
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Antioxidant
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
1 food-safety record found.
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include 3,4-Dihydroxycinnamic acid?
3,4-Dihydroxycinnamic acid appears on 2 regulatory/inventory lists including OEHHA Proposition 65 (3/2019), OEHHA Proposition 65 (1/2023). Source: EPA CPDat.
Is 3,4-Dihydroxycinnamic acid a carcinogen according to IARC?
3,4-Dihydroxycinnamic acid is classified by IARC as Group 2B — possibly carcinogenic to humans (evaluated 1992). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.
Is 3,4-Dihydroxycinnamic acid on the California Proposition 65 list?
Yes, 3,4-Dihydroxycinnamic acid is listed under California Proposition 65 for cancer. Source: California OEHHA Proposition 65.
Is 3,4-Dihydroxycinnamic acid used in cosmetics?
Yes, 3,4-Dihydroxycinnamic acid is also indexed as a cosmetic ingredient under the name Caffeic Acid. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 3,4-Dihydroxycinnamic acid come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, IARC Monographs, California Proposition 65, CosIng / Ingredients DB, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does 3,4-Dihydroxycinnamic acid have different safety status in cosmetics vs industrial chemicals?
3,4-Dihydroxycinnamic acid is classified GHS CMR hazard (H315, H319, H335, H351, H361) in the chemicals database but is allowed in EU cosmetics.
Is 3,4-Dihydroxycinnamic acid used outside industrial chemicals?
3,4-Dihydroxycinnamic acid also appears in cosmetics, food safety, cannabis databases.