Warning GHS07GHS09 NOAEL Data REACH Registered Cosmetic Ingredient

Triclosan

Also known as: 5-Chloro-2-(2,4-dichlorophenoxy)phenol, Phenol, 5-chloro-2-(2,4-dichlorophenoxy)-, EC No.: 222-182-2, BRN 2057142, Caswell No. 186A (+9 more)

CAS 3380-34-5

Triclosan (CAS 3380-34-5) is a chemical substance with GHS signal word Warning; key hazard signal: H315; H319; H400; H410. Key regulatory status: REACH registered, 40 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH.

View cosmetic safety profile for Triclosan →

SOURCE noael studies public
NOAEL studies
100
SOURCE chemical inventory jurisdictions
Regulatory lists
40
SOURCE eu clp annex vi
GHS signal
Warning

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 20 fields
Name
Triclosan
CAS Number
3380-34-5
DTXSID
DTXSID5032498
Molecular Formula
C12H7Cl3O2
InChI Key
XEFQLINVKFYRCS-UHFFFAOYSA-N
Monoisotopic Mass
287.951163
Synonyms
5-Chloro-2-(2,4-dichlorophenoxy)phenolPhenol, 5-chloro-2-(2,4-dichlorophenoxy)-EC No.: 222-182-2BRN 2057142Caswell No. 186ACloxifenolumEINECS 222-182-2EPA Pesticide Chemical Code 054901Irgasan DP300Phenyl ether, 2'-hydroxy-2,4,4'-trichloro-TriclosanumUNII-4NM5039Y5X

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications
Hazard ClassH-StatementsPictogramsSignal
Skin Irrit. 2; Eye Irrit. 2; Aquatic Acute 1; Aquatic Chronic 1H315; H319; H400; H410GHS07; GHS09Warning

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 22 records
BiocidePreservativeDeodorizer

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 40 records
ListKeywordSource
Europe; Personal careEuropean CommissionCosIng
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesCalifornia Department of Pesticide RegulationState of California
Cleaning products and household care - shoes; EuropeDanish Environmental Protection AgencyDanish EPA
Cleaning products and household care - shoes; EuropeDanish Environmental Protection AgencyDanish EPA
pharmaceuticalUS International Trade CommissionCPCat
Europe; Personal care - body hygiene - hand soapDanish Environmental Protection AgencyDanish EPA
detected; wastewaterUSGSUnited States Geological Survey (USGS)
active_ingredient; Europe; PesticidesCommission of the European CommunitiesCPCat
detected; Europe; Other direct contact consumer goodsDanish Environmental Protection AgencyDanish EPA
Europe; Personal care - deodorantDanish Environmental Protection AgencyDanish EPA
EuropeDanish Environmental Protection AgencyDanish EPA
detected; MN Chemical Screening; surface_waterMinnesota Pollution Control AgencyState of Minnesota
detected; MN Chemical Screening; surface_waterMinnesota Pollution Control AgencyState of Minnesota
detected; MN Chemical Screening; surface_waterMinnesota Pollution Control AgencyState of Minnesota
detected; MN Chemical Screening; surface_waterUSGSState of Minnesota
detected; MN Chemical Screening; wastewaterMinnesota Pollution Control AgencyState of Minnesota
detected; MN Chemical Screening; surface_waterMinnesota Pollution Control AgencyState of Minnesota
detected; drinking_water; MN Chemical ScreeningUSGSState of Minnesota
detected; drinking_water; MN Chemical ScreeningUSGSState of Minnesota
detected; drinking_water; MN Chemical ScreeningEPA & USGSState of Minnesota
detected; drinking_water; MN Chemical ScreeningEPA & USGSState of Minnesota
detected; drinking_water; MN Chemical ScreeningEPA & USGSState of Minnesota
detected; MN Chemical Screening; surface_waterMinnesota Pollution Control AgencyState of Minnesota
Canada; pharmaceuticalDrugBankDrugBank
Canada; pharmaceuticalDrugBankDrugBank
Europe; Furniture and Furnishings; nondetectDanish Environmental Protection AgencyDanish EPA
Europe; Food contact itemsDanish Environmental Protection AgencyDanish EPA
Europe; restrictedDanish Environmental Protection AgencyDanish EPA
children; EuropeDanish Environmental Protection AgencyDanish EPA
EuropeDanish Environmental Protection AgencyDanish EPA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 100 studies
ValueUnitEndpointRouteSpeciesSource
0.3%--humanUnifiedCodex:SCCS_SHADOW:beta.noael_studies
0.3%--humanUnifiedCodex:SCCS_SHADOW:beta.noael_studies
0.3%--humanUnifiedCodex:SCCS_SHADOW:beta.noael_studies
1----UnifiedCodex:SCCS_SHADOW:beta.noael_studies
1----UnifiedCodex:SCCS_SHADOW:beta.noael_studies
1.59%-oralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
3mg/kg bw/d--rabbitUnifiedCodex:SCCS_SHADOW:beta.noael_studies
3----UnifiedCodex:SCCS_SHADOW:beta.noael_studies
5.1%-oralrabbitUnifiedCodex:SCCS_SHADOW:beta.noael_studies
9----UnifiedCodex:SCCS_SHADOW:beta.noael_studies
10mg/kg bw/d-oralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
11----UnifiedCodex:SCCS_SHADOW:beta.noael_studies
12mg/kg bw/day--ratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
12mg/kg bw/d--ratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
12mg/kg/d--humanUnifiedCodex:SCCS_SHADOW:beta.noael_studies
12mg/kg bw/d--ratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
17---mouseUnifiedCodex:SCCS_SHADOW:beta.noael_studies
17---ratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
17----UnifiedCodex:SCCS_SHADOW:beta.noael_studies
21----UnifiedCodex:SCCS_SHADOW:beta.noael_studies
21----UnifiedCodex:SCCS_SHADOW:beta.noael_studies
21----UnifiedCodex:SCCS_SHADOW:beta.noael_studies
21----UnifiedCodex:SCCS_SHADOW:beta.noael_studies
25mg/kg bw/d--dogUnifiedCodex:SCCS_SHADOW:beta.noael_studies
=25mg/kg bw/d-oralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
=25mg/kg bw/d-oralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
25mg/kg bw/d-oraldogUnifiedCodex:SCCS_SHADOW:beta.noael_studies
25--oralmouseUnifiedCodex:SCCS_SHADOW:beta.noael_studies
30mg/kg bw/d---UnifiedCodex:SCCS_SHADOW:beta.noael_studies
30mg/kg/day-oralhumanUnifiedCodex:SCCS_SHADOW:beta.noael_studies
30mg/kg/d--humanUnifiedCodex:SCCS_SHADOW:beta.noael_studies
30mg/kg bw/d---UnifiedCodex:SCCS_SHADOW:beta.noael_studies
30mg/kg bw/d---UnifiedCodex:SCCS_SHADOW:beta.noael_studies
30mg/kg bw/d-oral-UnifiedCodex:SCCS_SHADOW:beta.noael_studies
38%-oral-UnifiedCodex:SCCS_SHADOW:beta.noael_studies
40%---UnifiedCodex:SCCS_SHADOW:beta.noael_studies
=50mg/kg bw/d-oralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
=50mg/kg bw/d-oralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
=50mg/kg bw/d---UnifiedCodex:SCCS_SHADOW:beta.noael_studies
50--oralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
=50mg/kg bw/d-oralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
50--oralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
50--oralrabbitUnifiedCodex:SCCS_SHADOW:beta.noael_studies
63----UnifiedCodex:SCCS_SHADOW:beta.noael_studies
75mg/kg---UnifiedCodex:SCCS_SHADOW:beta.noael_studies
75mg/kg bw/d-oralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
75mg/kg bw/d---UnifiedCodex:SCCS_SHADOW:beta.noael_studies
75mg/kg--ratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
75mg/kg bw/d-oralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
75mg/kg bw/d--mouseUnifiedCodex:SCCS_SHADOW:beta.noael_studies

Showing 50 of 100 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records
StatusNameEC NumberLink
RegisteredTriclosan222-182-2ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed_with_terms
Conditions
Specific information requirements: Obligations to provide information apply. These obligations are: 1. A person introducing this chemical must tell us in writing within 28 calendar days if any of the following circumstances have occurred in relation to their introduction (importation or manufacture): a. The function or use of triclosan has increased, or is likely to change, significantly; b. The amount of triclosan introduced by each importer into Australia has increased significantly compared to their usual importation volume, or likely to increase significantly; c. Manufacture of triclosan in Australia is proposed; d. Significant new information has become available to the applicant/notifier as to adverse environmental effects of triclosan such as those identified in this assessment (e.g. methyl-triclosan and 2,8-dichlorodibenzo-p-dioxine); e. Additional data has become available to the applicant/notifier to confirm and clarify the biological significance of the observed effects of triclosan on the development of tadpoles of the North American bullfrog, Rana catesbeiana. f. Additional information has become available to the applicant/notifier as to the adverse health effects of triclosan, including development of antimicrobial resistance to triclosan in clinical or natural settings; or g. Additional information has become available on the amount of triclosan that may be leached from textile and plastic articles under normal conditions of use, or from the sucking or mouthing of such (i.e. extraction into saliva). 2. A person who introduces this chemical must tell us in writing within 28 calendar days if they become aware of any of the following circumstances, namely, that since the assessment under the Industrial Chemicals (Notification and Assessment) Act 1989: a. the function or use of the chemical has changed, or is likely to change, significantly; b. the amount of the chemical being introduced has increased, or is likely to increase, significantly; c. in the case of a chemical not manufactured, or proposed to be manufactured, in Australia at the time of the assessment—it has begun to be manufactured in Australia; d. the method of manufacture of the chemical in Australia has changed, or is likely to change, in a way that may result in an increased risk of an adverse effect of the chemical on occupational health and safety, public health or the environment; e. additional information has become available to the person as to an adverse effect of the chemical on occupational health and safety, public health or the environment.

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE EU SCCS 4 opinions
OpinionDateConclusionMax Conc.Concerns
SCCS/1431/1122 March 2011Safe with restrictions — safe in specific product types only; not safe in leave-on body products or sprays0.3% in most approved uses; 0.2% in mouthwashAggregate exposure (thyroid disruption); endocrine disrupting properties (anti-thyroidal); antimicrobial resistance; note: EU subsequently restricted use further
SCCS/1404/1022 June 2010Scientific advice — preliminary opinion on antimicrobial resistance risk; not a standard safety conclusionN/A (advisory opinion)Antimicrobial and antibiotic cross-resistance risk; potential contribution to clinical antibiotic resistance; not a consumer safety conclusion per se
SCCP/1192/0821 January 2009Safe with restrictions — safe in specific product types only; not safe overall or in mouthwash at 0.3%0.3% in approved uses; mouthwash 0.15-0.2%Aggregate exposure; thyroid effects; antimicrobial resistance; endocrine disrupting potential
SCCP/0974/0610 October 2006Scientific advice — opinion on triclosan use in non-cosmetic consumer products (guidance document on epidemiological/clinical studies); not a standalone safety conclusionN/A (advisory/guidance document)Antimicrobial resistance; endocrine disruption; note: this is primarily a guidance/advisory document on study methodology for triclosan

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
restricted
Max
≤0.3% in toothpaste, hand soaps, body washes, bar soaps, deodorants (non-spray); ≤0.2% in face powder, foundation, nail products. Prohibited in mouthwashes and toothpaste for children under 3 years. Enforcement deadline: 31 October 2025
Category
Antimicrobial
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL TRICLOSAN
ChEMBL Phase
4
Adverse Events
1767
Bioactivity
21
View full pharmaceutical profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the GHS hazard classification for Triclosan?

Triclosan (CAS 3380-34-5) is classified under EU CLP Annex VI as Skin Irrit. 2; Eye Irrit. 2; Aquatic Acute 1; Aquatic Chronic 1 with signal word Warning. Hazard statements: H315; H319; H400; H410. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for Triclosan?

Triclosan has 100 NOAEL studies in the database. The lowest reported value is 0.3 % in human. Source: UnifiedCodex:SCCS_SHADOW:beta.noael_studies.

What regulatory lists include Triclosan?

Triclosan appears on 18 regulatory/inventory lists including Europe; Personal care, active_ingredient; Pesticides, Cleaning products and household care - shoes; Europe, and 15 more. Source: EPA CPDat.

Is Triclosan used in cosmetics?

Yes, Triclosan is also indexed as a cosmetic ingredient under the name Triclosan. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Triclosan come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Is Triclosan used outside industrial chemicals?

Triclosan also appears in cosmetics, pharmaceutical, cannabis databases.