NOAEL Data Cosmetic Ingredient

Enzacamene

Also known as: Bicyclo[2.2.1]heptan-2-one, 1,7,7-trimethyl-3-[(4-methylphenyl)methylene]-, Eusolex 6300, Neo Heliopan MBC, 3-(p-Methylbenzylidene)camphor, 3-(p-Methylbenzylidene)-DL-camphor (+13 more)

CAS 36861-47-9

Enzacamene (CAS 36861-47-9) is a chemical substance. Key regulatory status: 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS.

View cosmetic safety profile for Enzacamene (4-Methylbenzylidene Camphor) →

SOURCE NOAEL studies
NOAEL studies
35
SOURCE Chemical inventory jurisdictions
Regulatory lists
4
SOURCE EU CLP Annex VI
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 23 fields
Name
Enzacamene
CAS Number
36861-47-9
Molecular Formula
C18H22O
InChI Key
HEOCBCNFKCOKBX-UHFFFAOYSA-N
Monoisotopic Mass
254.167065
Synonyms
Bicyclo[2.2.1]heptan-2-one, 1,7,7-trimethyl-3-[(4-methylphenyl)methylene]-Eusolex 6300Neo Heliopan MBC3-(p-Methylbenzylidene)camphor3-(p-Methylbenzylidene)-DL-camphor3-(4-Methylbenzylidene)camphor3-(4-Methylbenzylidene)-DL-camphor3-(4'-Methylbenzylidene)camphor4-Methylbenzylidenecamphorp-MethylbenzylidenecamphorBicyclo[2.2.1]heptan-2-one, 1,7,7-trimethyl-3-[(4-methylphenyl)methylene]-, (+/-)-1,7,7-Trimethyl-3-[(4-methylphenyl)methylene]bicyclo[2.2.1]heptan-2-one

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 9 records
UV stabilizerFragrance

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 4 records
ListKeywordSource
consumer_productP&GProctor & Gamble
IFRA TransparencyIFRAIFRA
Canada; consumer_product; Substances in Products - Canada (4/2014)Government of CanadaCPCat
Canada; pharmaceuticalDrugBankDrugBank

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 35 of 35 studies
ValueUnitEndpointRouteSpeciesSource
1--oral-Regulatory source
4----Regulatory source
25--oralratRegulatory source
25mg/kg-dermalratRegulatory source
25mg/kg bw/day---Regulatory source
25mg/kg bw/day-oral-Regulatory source
=30mg/kg bw/day-oralratRegulatory source
66mg/kg bw/day-dermalhumanRegulatory source
100mg/kg/day-dermalratRegulatory source
100mg/kg bw/day-oral-Regulatory source
=400--oralratRegulatory source
400mg/kg/day-dermalratRegulatory source
400mg/kg bw /day-oral-Regulatory source
2000mg/kg bw/day--ratRegulatory source
8I3XWY40L9UNIIFDA UNII substance identifier--openFDA substances
=1-NOAELoral-SCCS Opinion
=4-NOAEL--SCCS Opinion
=10mg/kg bw/dayNOAEL--SCCS Opinion
=25-NOAELoralratSCCS Opinion
=25mg/kg/dayNOAELoralratSCCS Opinion
=25mg/kg bw/dayNOAELdermal-SCCS Opinion
=25mg/kgNOAELdermalratSCCS Opinion
=25mg/kg bw/dayNOAELoralratSCCS Opinion
=30mg/kg bw/dayNOAELoralratSCCS Opinion
=30mg/kg bw/dayNOAEL-ratSCCS Opinion
=50mg/kg/dayNOAEL-ratSCCS Opinion
=50mg/kg bw/dayNOAELoral-SCCS Opinion
=66mg/kg bw/dayNOAELdermalhumanSCCS Opinion
=100mg/kg bw/dayNOAEL--SCCS Opinion
=100mg/kg/dayNOAELdermalratSCCS Opinion
=100mg/kg bw/dayNOAELdermalratSCCS Opinion
=400-NOAELoralratSCCS Opinion
=400mg/kg/dayNOAELdermalratSCCS Opinion
=400mg/kg bw/dayNOAELoralratSCCS Opinion
=400mg/kg bw /dayNOAELoral-SCCS Opinion

Showing 35 of 35 studies

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE SCCS Opinion 2 opinions
OpinionDateConclusionMax Conc.Concerns
SCCP/1042/0610 October 2006The SCCP is of the opinion that presently the safe use of a maximum concentration of 4% 4-MBC in sunscreens cannot be established.4%Safe use of the proposed maximum concentration of 4% 4-MBC in sunscreens cannot presently be established.
SCCS/1640/2129 April 2022The SCCS cannot conclude on the safety of 4-MBC, because the information provided is insufficient to fully evaluate potential genotoxicity. Moreover, there is sufficient evidence that 4-MBC may act as an endocrine disruptor and has effects on both the thyroid and estrogen systems. ... the use of 4-MBC at the maximum concentration of 4% in cosmetic ingredients would not be safe. ... It is not possible to derive a maximum concentration for safe use of 4-MBC, because a genotoxicity potential cannot be excluded.4% (proposed use as UV-filter; SCCS found NOT safe and could not derive any safe maximum concentration)Information insufficient to fully evaluate potential genotoxicity (genotoxicity cannot be excluded); sufficient evidence that 4-MBC may act as an endocrine disruptor with effects on thyroid and estrogen systems; re-evaluation established a higher exposure level than the previous Opinion, lowering MoS so 4% would not be safe; no safe maximum concentration could be derived; environment not assessed (outside mandate).

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
sunscreen
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE ChEMBL / DailyMed ENZACAMENE
ChEMBL Phase
2
Adverse Events
0
Bioactivity
2
View full pharmaceutical profile →

Frequently Asked Questions

What is the NOAEL for Enzacamene?

Enzacamene has 35 NOAEL studies in the database. The lowest reported value is 1 mg/kg bw/day via oral. Source: Regulatory source.

What regulatory lists include Enzacamene?

Enzacamene appears on 4 regulatory/inventory lists including consumer_product, IFRA Transparency, Canada; consumer_product; Substances in Products - Canada (4/2014), and 1 more. Source: EPA CPDat.

Is Enzacamene used in cosmetics?

Yes, Enzacamene is also indexed as a cosmetic ingredient under the name Enzacamene (4-Methylbenzylidene Camphor). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Enzacamene come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Is Enzacamene used outside industrial chemicals?

Enzacamene also appears in cosmetics, pharmaceutical databases.