What is the NOAEL for Denatonium benzoate?
Denatonium benzoate has 13 NOAEL studies in the database. The lowest reported value is 4.99 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Denatonium benzoate
Also known as: Benzyl diethyl ((2,6-xylylcarbamoyl)methyl) ammonium benzoate, Benzyldiethyl((2,6-xylylcarbamoyl)methyl)ammonium benzoate, Caswell No. 083BB, EINECS 223-095-2, EPA Pesticide Chemical Code 009106 (+7 more)
CAS 3734-33-6
Denatonium benzoate (CAS 3734-33-6) is a chemical substance. Key regulatory status: REACH registered, 26 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
Denatonium benzoate is classified GHS Danger (H302, H332, H318, H412) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
13
SOURCE
chemical inventory jurisdictions
Regulatory lists
26
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
18 fields
Name
Denatonium benzoate
CAS Number
3734-33-6
DTXSID
DTXSID8034376
Molecular Formula
C21H28N2O.C7H6O2
InChI Key
VWTINHYPRWEBQY-UHFFFAOYSA-N
Monoisotopic Mass
446.256943
Synonyms
Benzyl diethyl ((2,6-xylylcarbamoyl)methyl) ammonium benzoateBenzyldiethyl((2,6-xylylcarbamoyl)methyl)ammonium benzoateCaswell No. 083BBEINECS 223-095-2EPA Pesticide Chemical Code 009106Lidocaine benzyl benzoateAversionDenatonii benzoasUNII-M5BA6GAF1OBitterant-bBitterant+PlusBitrex
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
Flavouring and nutrientDeodorizerFragranceViscosity modifier
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
26 records
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| pharmaceutical | US International Trade Commission | CPCat |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| consumer_product | P&G | Proctor & Gamble |
| Cleaning products and household care - laundry and fabric treatment - laundry detergent; Europe | Danish EPA | Danish EPA |
| Cleaning products and household care; Europe | Danish EPA | Danish EPA |
| Cleaning products and household care; Europe | Danish EPA | Danish EPA |
| IFRA Transparency | IFRA | IFRA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 13 of 13 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =4.99 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| M5BA6GAF1O | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| M5BA6GAF1O | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| M5BA6GAF1O | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| M5BA6GAF1O | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.2 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| =8 | mg/kg bw/day | LOAEL | oral | Monkey | ToxValDB_ECHA_IUCLID |
| =2 | % | LOEL | environmental | Rat | ToxValDB_ECOTOX |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| =15 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =16 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =60 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =535.896 | mg/kg bw/day | NOAEL | oral | Mouse | ToxValDB_ECHA_IUCLID |
Showing 13 of 13 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Denatonium benzoate | 223-095-2 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Cosmetic Ingredient
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Denatonium benzoate?
Denatonium benzoate appears on 11 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, active_ingredient; Pesticides, pharmaceutical, and 8 more. Source: EPA CPDat.
Is Denatonium benzoate used in cosmetics?
Yes, Denatonium benzoate is also indexed as a cosmetic ingredient under the name Denatonium Benzoate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Denatonium benzoate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Denatonium benzoate have different safety status in cosmetics vs industrial chemicals?
Denatonium benzoate is classified GHS Danger (H302, H332, H318, H412) in the chemicals database but is allowed in EU cosmetics.
Is Denatonium benzoate used outside industrial chemicals?
Denatonium benzoate also appears in cosmetics, cannabis databases.