What is the NOAEL for Ponceau 2R?
Ponceau 2R has 15 NOAEL studies in the database. The lowest reported value is 200 ug/day. Source: California Proposition 65.
NOAEL Data
IARC Group 2B
Prop 65
Cosmetic Ingredient
Ponceau 2R
Also known as: D & C Red No. 5, C.I. Food Red 5, 2,7-Naphthalenedisulfonic acid, 4-[2-(2,4-dimethylphenyl)diazenyl]-3-hydroxy-, sodium salt (1:2), 2,7-Naphthalenedisulfonic acid, 4-[(2,4-dimethylphenyl)azo]-3-hydroxy-, disodium salt, C.I. Acid Red 26, disodium salt (+14 more)
CAS 3761-53-3
Ponceau 2R (CAS 3761-53-3) is a chemical substance; key hazard signal: IARC Group 2B. Key regulatory status: California Proposition 65, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, IARC, CA Prop 65, EPA TRI.
SOURCE
noael studies public
NOAEL studies
15
SOURCE
chemical inventory jurisdictions
Regulatory lists
3
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
25 fields
Name
Ponceau 2R
CAS Number
3761-53-3
DTXSID
DTXSID8021228
Molecular Formula
C18H16N2O7S2.2Na
InChI Key
DKUHOIWLFSTHJN-UHFFFAOYSA-L
Monoisotopic Mass
482.019432
Synonyms
D & C Red No. 5C.I. Food Red 52,7-Naphthalenedisulfonic acid, 4-[2-(2,4-dimethylphenyl)diazenyl]-3-hydroxy-, sodium salt (1:2)2,7-Naphthalenedisulfonic acid, 4-[(2,4-dimethylphenyl)azo]-3-hydroxy-, disodium saltC.I. Acid Red 26, disodium saltD and C RedD and C Red No. 5D&C Red No. 5Acetacid Red JAcid Leather Red P2RAcid Leather Red KPRAcid Leather Scarlet IRW
IARC Carcinogen Classification
Carcinogenic hazard classification from IARC monograph evaluations.
SOURCE
IARC Monographs on the Identification of Carcinogenic Hazards to Humans
1 records
| Group | Meaning | Evaluated | Volume |
|---|---|---|---|
| Group 2B | Possibly carcinogenic | 1987 | 8, Sup 7 |
California Proposition 65
California OEHHA listing status and toxicity category.
SOURCE
California OEHHA Proposition 65 List
1 records
| Chemical | Toxicity Type | Cancer | Developmental | Listed |
|---|---|---|---|---|
| - | cancer | Yes | No | - |
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| OEHHA Proposition 65 (3/2019) | STATE OF CALIFORNIA ENVIRONMENTAL PROTECTION AGENCY | OEHHA Proposition 65 List |
| OEHHA Proposition 65 (1/2023) | California Office of Environmental Health Hazard Assessment | OEHHA Proposition 65 List |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 15 of 15 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| SQE200 | ug/day | California Proposition 65 NSRL | - | - | California Proposition 65 |
| SQE200 | ug/day | California Proposition 65 NSRL | - | - | California Proposition 65 |
| SQE200 | ug/day | California Proposition 65 NSRL | - | - | California Proposition 65 |
| SQE200 | ug/day | California Proposition 65 NSRL | - | - | California Proposition 65 |
| SQEcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| SQEcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| SQEcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| SQEcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| U3J3635T4U | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| U3J3635T4U | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| U3J3635T4U | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| U3J3635T4U | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2B | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 2 | unitless | IARC group | - | - | NTP_ICE_cancer |
| =23160 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
Showing 15 of 15 studies
EPA Toxic Release Inventory (TRI)
TRI hazard and reporting flags for the matched chemical.
SOURCE
EPA Toxics Release Inventory (TRI) chemical list
1 records
| Chemical | Category | Flags |
|---|---|---|
| C.I. Food Red 5 | - | - |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Colorant
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Ponceau 2R?
Ponceau 2R appears on 3 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, OEHHA Proposition 65 (3/2019), OEHHA Proposition 65 (1/2023). Source: EPA CPDat.
Is Ponceau 2R a carcinogen according to IARC?
Ponceau 2R is classified by IARC as Group 2B — possibly carcinogenic to humans (evaluated 1987). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.
Is Ponceau 2R on the California Proposition 65 list?
Yes, Ponceau 2R is listed under California Proposition 65 for cancer. Source: California OEHHA Proposition 65.
Is Ponceau 2R used in cosmetics?
Yes, Ponceau 2R is also indexed as a cosmetic ingredient under the name CI 15525. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Ponceau 2R come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, California Proposition 65, EPA Toxics Release Inventory, CosIng / Ingredients DB, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Ponceau 2R used outside industrial chemicals?
Ponceau 2R also appears in cosmetics, cannabis databases.