What is the NOAEL for Sodium (2-pyridylthio)-N-oxide?
Sodium (2-pyridylthio)-N-oxide has 29 NOAEL studies in the database. The lowest reported value is 12.7840469261165 uM. Source: NTP_ICE_endocrine.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Sodium (2-pyridylthio)-N-oxide
Also known as: 2-Mercaptopyridine N-oxide sodium salt, EINECS 223-296-5, (1-Hydroxy-2-pyridinethione), sodium salt, (1-Hydroxy-2-pyridinethione), sodium salt, tech., 2-Mercaptopyridine oxide sodium salt (+12 more)
CAS 3811-73-2
Sodium (2-pyridylthio)-N-oxide (CAS 3811-73-2) is a chemical substance. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
Sodium (2-pyridylthio)-N-oxide is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H312, H332, H311, H331, H315, H317, H319).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
29
SOURCE
chemical inventory jurisdictions
Regulatory lists
3
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
22 fields
Name
Sodium (2-pyridylthio)-N-oxide
CAS Number
3811-73-2
DTXSID
DTXSID3042390
Molecular Formula
C5H5NOS.Na
InChI Key
WNGMMIYXPIAYOB-UHFFFAOYSA-M
Synonyms
2-Mercaptopyridine N-oxide sodium saltEINECS 223-296-5(1-Hydroxy-2-pyridinethione), sodium salt(1-Hydroxy-2-pyridinethione), sodium salt, tech.2-Mercaptopyridine oxide sodium salt2-Mercaptopyridine 1-oxide sodium salt2-Mercaptopyridine-N-oxide sodium saltNSC 4483Omadine sodium1-Oxo-2-pyridinethiol sodium salt2-Pyridinethiol N-oxide sodium salt2-Pyridinethiol-1-oxide sodium salt
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
6 records
Biocide
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| CEDI | FDA | United States Food and Drug Administration (FDA) |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| banned; Europe; Personal care | European Commission | CosIng |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 29 of 29 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 12.7840469261165 | uM | AC50 | - | - | NTP_ICE_endocrine |
| 13.9435901122095 | uM | ACC | - | - | NTP_ICE_endocrine |
| 6L3991491R | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6L3991491R | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6L3991491R | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6L3991491R | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =1.4 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =1.5 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =2 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =2.5 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =2.8 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =3.5 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =8.1 | mg/m3 | LOAEL | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =15 | mg/kg bw/day | LOAEL | dermal | Rat | ToxValDB_ECHA_IUCLID |
| =75 | mg/kg bw/day | LOAEL | oral | Monkey | ToxValDB_ECHA_IUCLID |
| =0.1 | mg/kg bw/day | LOEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 0.001 | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 0.00872 | unitless | Model Score | - | - | NTP_ICE_endocrine |
| =0.46 | mg/m3 | NOAEL | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =0.5 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =0.7 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =1.4 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =1.5 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =3.5 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =5 | mg/kg bw/day | NOAEL | dermal | Rabbit | ToxValDB_ECHA_IUCLID |
| <25 | mg/kg bw/day | NOAEL | oral | Monkey | ToxValDB_ECHA_IUCLID |
| =5 | mg/kg bw/day | NOEL | dermal | Mouse | ToxValDB_ECHA_IUCLID |
| =15 | mg/kg bw/day | NOEL | dermal | Mouse | ToxValDB_ECHA_IUCLID |
Showing 29 of 29 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Pyridine-2-thiol 1-oxide, sodium salt | 223-296-5 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Preservative
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
PYRITHIONE SODIUM
ChEMBL Phase
-1
Adverse Events
0
Bioactivity
0
Frequently Asked Questions
What regulatory lists include Sodium (2-pyridylthio)-N-oxide?
Sodium (2-pyridylthio)-N-oxide appears on 3 regulatory/inventory lists including CEDI, active_ingredient; Europe; Pesticides, banned; Europe; Personal care. Source: EPA CPDat.
Is Sodium (2-pyridylthio)-N-oxide used in cosmetics?
Yes, Sodium (2-pyridylthio)-N-oxide is also indexed as a cosmetic ingredient under the name Sodium Pyrithione. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Sodium (2-pyridylthio)-N-oxide come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does Sodium (2-pyridylthio)-N-oxide have different safety status in cosmetics vs industrial chemicals?
Sodium (2-pyridylthio)-N-oxide is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H312, H332, H311, H331, H315, H317, H319).
Is Sodium (2-pyridylthio)-N-oxide used outside industrial chemicals?
Sodium (2-pyridylthio)-N-oxide also appears in cosmetics, pharmaceutical databases.