What is the NOAEL for Pentaerythrityl tetrabenzoate?
Pentaerythrityl tetrabenzoate has 5 NOAEL studies in the database. The lowest reported value is U7L44GIS4O UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Pentaerythrityl tetrabenzoate
Also known as: 1,3-Propanediol, 2,2-bis[(benzoyloxy)methyl]-, 1,3-dibenzoate, Benzoflex S 552, 1,3-Propanediol, 2,2-bis[(benzoyloxy)methyl]-, dibenzoate, NSC 166502, Pentaerythritol, tetrabenzoate (+10 more)
CAS 4196-86-5
Pentaerythrityl tetrabenzoate (CAS 4196-86-5) is a chemical substance. Key regulatory status: REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
View cosmetic safety profile for Pentaerythrityl Tetrabenzoate →
SOURCE
noael studies public
NOAEL studies
5
SOURCE
chemical inventory jurisdictions
Regulatory lists
2
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
21 fields
Name
Pentaerythrityl tetrabenzoate
CAS Number
4196-86-5
DTXSID
DTXSID8024608
Molecular Formula
C33H28O8
InChI Key
MINJAOUGXYRTEI-UHFFFAOYSA-N
Monoisotopic Mass
552.178418
Synonyms
1,3-Propanediol, 2,2-bis[(benzoyloxy)methyl]-, 1,3-dibenzoateBenzoflex S 5521,3-Propanediol, 2,2-bis[(benzoyloxy)methyl]-, dibenzoateNSC 166502Pentaerythritol, tetrabenzoatePentaerythritol tetrabenzoate homopolymer[3-Benzoyloxy-2,2-bis(benzoyloxymethyl)propyl] benzoatepentaerythritol tetrabenzoateDIBENZOATE, 2,2-BIS[(BENZYLOXY)METHYL]-1,3- PROPENEDIYLEC No.: 224-079-82,2-Bis[(benzoyloxy)methyl]dibenzoate propanediol2,2-Bis((benzoyloxy)methyl)dibenzoate propanediol
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
1 records
Softener and conditioner
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
2 records
| List | Keyword | Source |
|---|---|---|
| CEDI | FDA | United States Food and Drug Administration (FDA) |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 5 of 5 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| U7L44GIS4O | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| U7L44GIS4O | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| U7L44GIS4O | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| U7L44GIS4O | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =1158 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
Showing 5 of 5 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Pentaerythritol tetrabenzoate | 224-079-8 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Emollient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL1533629
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Frequently Asked Questions
What regulatory lists include Pentaerythrityl tetrabenzoate?
Pentaerythrityl tetrabenzoate appears on 2 regulatory/inventory lists including CEDI, Indirect additives food contact (10/2018). Source: EPA CPDat.
Is Pentaerythrityl tetrabenzoate used in cosmetics?
Yes, Pentaerythrityl tetrabenzoate is also indexed as a cosmetic ingredient under the name Pentaerythrityl Tetrabenzoate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Pentaerythrityl tetrabenzoate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is Pentaerythrityl tetrabenzoate used outside industrial chemicals?
Pentaerythrityl tetrabenzoate also appears in cosmetics, pharmaceutical databases.