What is the NOAEL for 3-Mercaptopropyltrimethoxysilane?
3-Mercaptopropyltrimethoxysilane has 6 NOAEL studies in the database. The lowest reported value is 2.4 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
3-Mercaptopropyltrimethoxysilane
Also known as: 1-Propanethiol, 3-(trimethoxysilyl)-, BRN 2038119, EINECS 224-588-5, gamma-Mercaptopropyltrimethoxysilane, Silane, 3-mercaptopropyltrimethoxy- (+2 more)
CAS 4420-74-0
3-Mercaptopropyltrimethoxysilane (CAS 4420-74-0) is a chemical substance. Key regulatory status: REACH registered, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
View cosmetic safety profile for Mercaptopropyltrimethoxysilane →
Cross-Vertical Regulatory Divergence
3-Mercaptopropyltrimethoxysilane is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H312, H317, H319, H411).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
6
SOURCE
chemical inventory jurisdictions
Regulatory lists
0
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
13 fields
Name
3-Mercaptopropyltrimethoxysilane
CAS Number
4420-74-0
DTXSID
DTXSID2044428
Molecular Formula
C6H16O3SSi
InChI Key
UUEWCQRISZBELL-UHFFFAOYSA-N
Monoisotopic Mass
196.058942
Synonyms
1-Propanethiol, 3-(trimethoxysilyl)-BRN 2038119EINECS 224-588-5gamma-MercaptopropyltrimethoxysilaneSilane, 3-mercaptopropyltrimethoxy-Union carbide A-189(gamma-mercaptopropyl)trimethoxysilane
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
49 records
Softener and conditionerAntioxidantFillerConductive agentChemical reaction regulatorAdhesion/cohesion promoterHardenerWetting agent (non-aqueous)
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 6 of 6 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =2.4 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| =130 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 8CB1M08OIW | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8CB1M08OIW | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8CB1M08OIW | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8CB1M08OIW | UNII | FDA UNII substance identifier | - | - | openFDA substances |
Showing 6 of 6 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 3-trimethoxysilylpropane-1-thiol | 224-588-5 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Cosmetic Ingredient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL3185147
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Frequently Asked Questions
Is 3-Mercaptopropyltrimethoxysilane used in cosmetics?
Yes, 3-Mercaptopropyltrimethoxysilane is also indexed as a cosmetic ingredient under the name Mercaptopropyltrimethoxysilane. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 3-Mercaptopropyltrimethoxysilane come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does 3-Mercaptopropyltrimethoxysilane have different safety status in cosmetics vs industrial chemicals?
3-Mercaptopropyltrimethoxysilane is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H312, H317, H319, H411).
Is 3-Mercaptopropyltrimethoxysilane used outside industrial chemicals?
3-Mercaptopropyltrimethoxysilane also appears in cosmetics, pharmaceutical databases.