What is the NOAEL for Farnesol?
Farnesol has 70 NOAEL studies in the database. The lowest reported value is 0 % via Dermal. Source: NTP_ICE_skin_sensitization.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Farnesol
Also known as: Nikkosome, 3,7,11-Trimethyl-2,6,10-dodecatrien-1-ol, Farnesyl alcohol, 3,7,11-Trimethyl-2,6,10-dodecen-1-ol, FCI 119a (+7 more)
CAS 4602-84-0
Farnesol (CAS 4602-84-0) is a chemical substance. Key regulatory status: REACH registered, 40 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
70
SOURCE
chemical inventory jurisdictions
Regulatory lists
40
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
18 fields
Name
Farnesol
CAS Number
4602-84-0
DTXSID
DTXSID3032389
Molecular Formula
C15H26O
InChI Key
CRDAMVZIKSXKFV-UHFFFAOYSA-N
Monoisotopic Mass
222.198365
Synonyms
Nikkosome3,7,11-Trimethyl-2,6,10-dodecatrien-1-olFarnesyl alcohol3,7,11-Trimethyl-2,6,10-dodecen-1-olFCI 119a2,6,10-dodecatrien-1-ol, 3,7,11-trimetil-3,7,11-Trimethyldodeca-2,6,10-trien-1-olEINECS 225-004-1FEMA No. 2478EPA Pesticide Chemical Code 128911UNII-EB41QIU6JL3,7,11-trimethyl-2,6,10-dodecatrienol
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
FragranceDeodorizerNo specific technical functionSolventHumectantFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
40 records
| List | Keyword | Source |
|---|---|---|
| Europe; Personal care; restricted | European Commission | CosIng |
| Europe | Danish Environmental Protection Agency | Danish EPA |
| Europe | European Commission | Fl@vis |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | California Department of Pesticide Regulation | State of California |
| Cleaning products and household care - air freshener; Cleaning products and household care - laundry and fabric treatment - fabric deodorizer; Europe; nondetect; Vehicle - car interior - auto air freshener | Danish Environmental Protection Agency | Danish EPA |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| active_ingredient; agricultural; Pesticides | USDA | United States Department of Agriculture (USDA) |
| active_ingredient; agricultural; Pesticides | USDA | United States Department of Agriculture (USDA) |
| active_ingredient; agricultural; Pesticides | USDA | United States Department of Agriculture (USDA) |
| active_ingredient; agricultural; Pesticides | USDA | United States Department of Agriculture (USDA) |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - specialized bath products - bath salts | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; detected; Europe; Personal care - fragrance | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - make-up and related | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - make-up and related | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - deodorant | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - deodorant | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - deodorant | Danish Environmental Protection Agency | Danish EPA |
| Australia; Food and drug - smoking-related products | New Zealand ESR | CPCat |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product; Europe; nondetect | Danish Environmental Protection Agency | Danish EPA |
| Canada; pharmaceutical | DrugBank | DrugBank |
| consumer_product; Europe; nondetect | Danish Environmental Protection Agency | Danish EPA |
| consumer_product | P&G | Proctor & Gamble |
| Cleaning products and household care - laundry and fabric treatment - laundry detergent; Europe | Danish EPA | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 50 of 70 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 23.3014235771792 | uM | AC50 | - | - | NTP_ICE_endocrine |
| 82.29832096 | uM | AC50 | - | - | NTP_ICE_endocrine |
| 25.1957181337932 | uM | ACC | - | - | NTP_ICE_endocrine |
| 69.24006543 | uM | ACC | - | - | NTP_ICE_endocrine |
| =0.8 | mg/kg bw/day | ADI | - | Consumers | EFSA_OpenFoodTox_OpenFoodToxTX22809_2023.xlsx |
| 21 | ug/mL | CD54, EC200 | Dermal | - | NTP_ICE_skin_sensitization |
| 7.96 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| 34.36 | ug/mL | CV70 | Dermal | - | NTP_ICE_skin_sensitization |
| 42.3 | ug/mL | CV75 | Dermal | - | NTP_ICE_skin_sensitization |
| 2.083 | % | Concentration, 5% incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 2.143 | % | Concentration, 5% incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 3.125 | % | Concentration, 5% incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 3.75 | % | Concentration, 5% incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 7.5 | % | Concentration, 5% incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 1.667 | % | Concentration, one positive response | Dermal | Human | NTP_ICE_skin_sensitization |
| 1.714 | % | Concentration, one positive response | Dermal | Human | NTP_ICE_skin_sensitization |
| 2.5 | % | Concentration, one positive response | Dermal | Human | NTP_ICE_skin_sensitization |
| 6 | % | Concentration, one positive response | Dermal | Human | NTP_ICE_skin_sensitization |
| =1.85 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 7.3 | % | Depletion Cys | Dermal | - | NTP_ICE_skin_sensitization |
| - | % | Depletion Lys | Dermal | - | NTP_ICE_skin_sensitization |
| 12.972 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| 4.1 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| >2000 | uM | EC3 | Dermal | - | NTP_ICE_skin_sensitization |
| EB41QIU6JL | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| EB41QIU6JL | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| EB41QIU6JL | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| EB41QIU6JL | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 23.31 | uM | IC50 | Dermal | - | NTP_ICE_skin_sensitization |
| 1.62 | ratio | Imax | Dermal | - | NTP_ICE_skin_sensitization |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 8 | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 16 | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 24 | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 28 | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 1529 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| 2865 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| 6750 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| 7776 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| 8100 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| 1406 | ug/cm2 | Induction dose per skin area, 5% incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 1446 | ug/cm2 | Induction dose per skin area, 5% incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 2109 | ug/cm2 | Induction dose per skin area, 5% incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 2430 | ug/cm2 | Induction dose per skin area, 5% incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 5062.5 | ug/cm2 | Induction dose per skin area, 5% incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 1125 | ug/cm2 | Induction dose per skin area, one positive response | Dermal | Human | NTP_ICE_skin_sensitization |
| 1157 | ug/cm2 | Induction dose per skin area, one positive response | Dermal | Human | NTP_ICE_skin_sensitization |
| 1688 | ug/cm2 | Induction dose per skin area, one positive response | Dermal | Human | NTP_ICE_skin_sensitization |
| 1944 | ug/cm2 | Induction dose per skin area, one positive response | Dermal | Human | NTP_ICE_skin_sensitization |
| 4050 | ug/cm2 | Induction dose per skin area, one positive response | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 50 of 70 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Farnesol | 225-004-1 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
Mandatory fragrance allergen labeling when >0.001% in leave-on products or >0.01% in rinse-off products. Concentration limits for use as deodorant active defined by product type under Annex III restrictions.
Category
deodorant
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Farnesol?
Farnesol appears on 20 regulatory/inventory lists including Europe; Personal care; restricted, Europe, active_ingredient; Pesticides, and 17 more. Source: EPA CPDat.
Is Farnesol used in cosmetics?
Yes, Farnesol is also indexed as a cosmetic ingredient under the name Farnesol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Farnesol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Farnesol used outside industrial chemicals?
Farnesol also appears in cosmetics, food safety, cannabis databases.