NOAEL Data REACH Registered Cosmetic Ingredient

Farnesol

Also known as: Nikkosome, 3,7,11-Trimethyl-2,6,10-dodecatrien-1-ol, Farnesyl alcohol, 3,7,11-Trimethyl-2,6,10-dodecen-1-ol, FCI 119a (+7 more)

CAS 4602-84-0

Farnesol (CAS 4602-84-0) is a chemical substance. Key regulatory status: REACH registered, 40 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for Farnesol →

SOURCE NOAEL studies

NOAEL studies

SOURCE Chemical inventory jurisdictions

Regulatory lists

SOURCE EU CLP Annex VI

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 17 fields

Name

Farnesol

CAS Number

4602-84-0

Molecular Formula

C15H26O

InChI Key

CRDAMVZIKSXKFV-UHFFFAOYSA-N

Monoisotopic Mass

222.198365

Synonyms

Nikkosome3,7,11-Trimethyl-2,6,10-dodecatrien-1-olFarnesyl alcohol3,7,11-Trimethyl-2,6,10-dodecen-1-olFCI 119a2,6,10-dodecatrien-1-ol, 3,7,11-trimetil-3,7,11-Trimethyldodeca-2,6,10-trien-1-olEINECS 225-004-1FEMA No. 2478EPA Pesticide Chemical Code 128911UNII-EB41QIU6JL3,7,11-trimethyl-2,6,10-dodecatrienol

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 60 records

FragranceDeodorizerNo specific technical functionSolventHumectantFlavouring and nutrient

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 40 records

List	Keyword	Source
Europe; Personal care; restricted	European Commission	CosIng
Europe	Danish Environmental Protection Agency	Danish EPA
Europe	European Commission	Fl@vis
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	California Department of Pesticide Regulation	State of California
Cleaning products and household care - air freshener; Cleaning products and household care - laundry and fabric treatment - fabric deodorizer; Europe; nondetect; Vehicle - car interior - auto air freshener	Danish Environmental Protection Agency	Danish EPA
active_ingredient; Europe; Pesticides	Commission of the European Communities	CPCat
active_ingredient; agricultural; Pesticides	USDA	United States Department of Agriculture (USDA)
active_ingredient; agricultural; Pesticides	USDA	United States Department of Agriculture (USDA)
active_ingredient; agricultural; Pesticides	USDA	United States Department of Agriculture (USDA)
active_ingredient; agricultural; Pesticides	USDA	United States Department of Agriculture (USDA)
Europe; Personal care	Danish Environmental Protection Agency	Danish EPA
children; Europe; Personal care	Danish Environmental Protection Agency	Danish EPA
children; Europe; Personal care - specialized bath products - bath salts	Danish Environmental Protection Agency	Danish EPA
children; Europe; Personal care	Danish Environmental Protection Agency	Danish EPA
children; Europe; Personal care	Danish Environmental Protection Agency	Danish EPA
children; detected; Europe; Personal care - fragrance	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Personal care - make-up and related	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Personal care - make-up and related	Danish Environmental Protection Agency	Danish EPA
Europe; Personal care - deodorant	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Personal care - deodorant	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Personal care - deodorant	Danish Environmental Protection Agency	Danish EPA
Australia; Food and drug - smoking-related products	New Zealand ESR	CPCat
Europe; Personal care	Danish Environmental Protection Agency	Danish EPA
Europe; Personal care	Danish Environmental Protection Agency	Danish EPA
Europe; Personal care	Danish Environmental Protection Agency	Danish EPA
IFRA Transparency	IFRA	IFRA
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)	FDA	United States Food and Drug Administration (FDA)
consumer_product; Europe; nondetect	Danish Environmental Protection Agency	Danish EPA
Canada; pharmaceutical	DrugBank	DrugBank
consumer_product; Europe; nondetect	Danish Environmental Protection Agency	Danish EPA
consumer_product	P&G	Proctor & Gamble
Cleaning products and household care - laundry and fabric treatment - laundry detergent; Europe	Danish EPA	Danish EPA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 67 studies

Value	Unit	Endpoint	Route	Species	Source
23.3	uM	AC50	-	-	NTP ICE endocrine
82.3	uM	AC50	-	-	NTP ICE endocrine
25.2	uM	ACC	-	-	NTP ICE endocrine
69.24	uM	ACC	-	-	NTP ICE endocrine
=0.8	mg/kg bw/day	ADI	-	Consumers	EFSA
21	ug/mL	CD54, EC200	Dermal	-	NTP ICE skin sensitization
7.96	ug/mL	CD86, EC150	Dermal	-	NTP ICE skin sensitization
34.36	ug/mL	CV70	Dermal	-	NTP ICE skin sensitization
42.3	ug/mL	CV75	Dermal	-	NTP ICE skin sensitization
2.083	%	Concentration, 5% incidence of positive responses	Dermal	Human	NTP ICE skin sensitization
2.143	%	Concentration, 5% incidence of positive responses	Dermal	Human	NTP ICE skin sensitization
3.125	%	Concentration, 5% incidence of positive responses	Dermal	Human	NTP ICE skin sensitization
3.75	%	Concentration, 5% incidence of positive responses	Dermal	Human	NTP ICE skin sensitization
7.5	%	Concentration, 5% incidence of positive responses	Dermal	Human	NTP ICE skin sensitization
1.667	%	Concentration, one positive response	Dermal	Human	NTP ICE skin sensitization
1.714	%	Concentration, one positive response	Dermal	Human	NTP ICE skin sensitization
2.5	%	Concentration, one positive response	Dermal	Human	NTP ICE skin sensitization
6	%	Concentration, one positive response	Dermal	Human	NTP ICE skin sensitization
=1.85	mg/m3	DNEL systemic	inhalation	Human	ToxValDB GESTIS DNEL
7.3	%	Depletion Cys	Dermal	-	NTP ICE skin sensitization
0	%	Depletion Lys	Dermal	-	NTP ICE skin sensitization
12.97	uM	EC1.5	Dermal	-	NTP ICE skin sensitization
4.1	%	EC3	Dermal	Mouse	NTP ICE skin sensitization
>2000	uM	EC3	Dermal	-	NTP ICE skin sensitization
EB41QIU6JL	UNII	FDA UNII substance identifier	-	-	openFDA substances
23.31	uM	IC50	Dermal	-	NTP ICE skin sensitization
1.62	ratio	Imax	Dermal	-	NTP ICE skin sensitization
0	%	Incidence of positive responses	Dermal	Human	NTP ICE skin sensitization
8	%	Incidence of positive responses	Dermal	Human	NTP ICE skin sensitization
16	%	Incidence of positive responses	Dermal	Human	NTP ICE skin sensitization
24	%	Incidence of positive responses	Dermal	Human	NTP ICE skin sensitization
28	%	Incidence of positive responses	Dermal	Human	NTP ICE skin sensitization
1529	ug/cm2	Induction dose per skin area	Dermal	Human	NTP ICE skin sensitization
2865	ug/cm2	Induction dose per skin area	Dermal	Human	NTP ICE skin sensitization
6750	ug/cm2	Induction dose per skin area	Dermal	Human	NTP ICE skin sensitization
7776	ug/cm2	Induction dose per skin area	Dermal	Human	NTP ICE skin sensitization
8100	ug/cm2	Induction dose per skin area	Dermal	Human	NTP ICE skin sensitization
1406	ug/cm2	Induction dose per skin area, 5% incidence of positive responses	Dermal	Human	NTP ICE skin sensitization
1446	ug/cm2	Induction dose per skin area, 5% incidence of positive responses	Dermal	Human	NTP ICE skin sensitization
2109	ug/cm2	Induction dose per skin area, 5% incidence of positive responses	Dermal	Human	NTP ICE skin sensitization
2430	ug/cm2	Induction dose per skin area, 5% incidence of positive responses	Dermal	Human	NTP ICE skin sensitization
5063	ug/cm2	Induction dose per skin area, 5% incidence of positive responses	Dermal	Human	NTP ICE skin sensitization
1125	ug/cm2	Induction dose per skin area, one positive response	Dermal	Human	NTP ICE skin sensitization
1157	ug/cm2	Induction dose per skin area, one positive response	Dermal	Human	NTP ICE skin sensitization
1688	ug/cm2	Induction dose per skin area, one positive response	Dermal	Human	NTP ICE skin sensitization
1944	ug/cm2	Induction dose per skin area, one positive response	Dermal	Human	NTP ICE skin sensitization
4050	ug/cm2	Induction dose per skin area, one positive response	Dermal	Human	NTP ICE skin sensitization
>5000	mg/kg bw	LD50	oral	Rat	NTP ICE acute oral
=6000	mg/kg bw	LD50	oral	Rat	NTP ICE acute oral
>1.774e+4	mg/kg bw	LD50	oral	Rat	NTP ICE acute oral

Showing 50 of 67 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA 1 records

Status	Name	EC Number	Link
Registered	Farnesol	225-004-1	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

restricted

Max

Mandatory fragrance allergen labeling when >0.001% in leave-on products or >0.01% in rinse-off products. Concentration limits for use as deodorant active defined by product type under Annex III restrictions.

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA 1 records

ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for Farnesol?

Farnesol has 67 NOAEL studies in the database. The lowest reported value is 0 % via Dermal. Source: NTP ICE skin sensitization.

What regulatory lists include Farnesol?

Farnesol appears on 20 regulatory/inventory lists including Europe; Personal care; restricted, Europe, active_ingredient; Pesticides, and 17 more. Source: EPA CPDat.

Is Farnesol used in cosmetics?

Yes, Farnesol is also indexed as a cosmetic ingredient under the name Farnesol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Farnesol come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Is Farnesol used outside industrial chemicals?

Farnesol also appears in cosmetics, food safety, cannabis databases.