What is the NOAEL for 1,8-Cineol?
1,8-Cineol has 19 NOAEL studies in the database. The lowest reported value is 7.05 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
1,8-Cineol
Also known as: Eucalyptol, Cineole, EINECS 207-431-5, FEMA No. 2465, NCI-C56575 (+5 more)
CAS 470-82-6
1,8-Cineol (CAS 470-82-6) is a chemical substance. Key regulatory status: REACH registered, 21 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
19
SOURCE
chemical inventory jurisdictions
Regulatory lists
21
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
16 fields
Name
1,8-Cineol
CAS Number
470-82-6
DTXSID
DTXSID4020616
Molecular Formula
C10H18O
InChI Key
WEEGYLXZBRQIMU-UHFFFAOYSA-N
Monoisotopic Mass
154.135765
Synonyms
EucalyptolCineoleEINECS 207-431-5FEMA No. 2465NCI-C565752-Oxa-1,3,3-trimethylbicyclo(2.2.2)octane1,8-Oxido-p-menthaneSoledumEukalyptolUNII-RV6J6604TK
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
FragranceHumectantFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
21 records
| List | Keyword | Source |
|---|---|---|
| Europe | European Commission | Fl@vis |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| active_ingredient; Australia | Australian Pesticides and Veterinary Medicines Authority | CPCat |
| active_ingredient; animal_products; Europe; pharmaceutical; residue | EU | CPCat |
| detected; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Vehicle - car interior - auto air freshener | Danish Environmental Protection Agency | Danish EPA |
| air; Cleaning products and household care - air freshener; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - sexual wellness | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - sexual wellness | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - liniment | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - liniment | Danish Environmental Protection Agency | Danish EPA |
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| consumer_product | P&G | Proctor & Gamble |
| air; Cleaning products and household care - laundry and fabric treatment; detected; emissions | Elsevier | CPCat |
| air; detected; emissions; Personal care | Elsevier | CPCat |
| air; Cleaning products and household care; detected; emissions | Elsevier | CPCat |
| air; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 19 of 19 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =7.05 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| RV6J6604TK | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| RV6J6604TK | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| RV6J6604TK | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| RV6J6604TK | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 10370 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| =100 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =250 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| =64.15 | mg/kg bw/day | NOAEL | oral | Mouse | ToxValDB_ECHA_IUCLID |
| 200 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 500 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| =562.5 | mg/kg bw/day | NOAEL | oral | Mouse | ToxValDB_EFSA |
| =562.5 | mg/kg bw/day | NOAEL | oral: capsule | Mouse | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =562.5 | mg/kg bw/day | NOAEL | oral: capsule | Mouse | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =1000 | mg/kg bw | NOAEL | oral: gavage | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =1000 | mg/kg bw | NOAEL | oral: gavage | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 19 of 19 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Cineole | 207-431-5 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
1.3%
Category
Other
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
EUCALYPTOL
ChEMBL Phase
3
Adverse Events
5
Bioactivity
6
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include 1,8-Cineol?
1,8-Cineol appears on 19 regulatory/inventory lists including Europe, active_ingredient; Europe; Pesticides, active_ingredient; Australia, and 16 more. Source: EPA CPDat.
Is 1,8-Cineol used in cosmetics?
Yes, 1,8-Cineol is also indexed as a cosmetic ingredient under the name Eucalyptol Cosmetic. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 1,8-Cineol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is 1,8-Cineol used outside industrial chemicals?
1,8-Cineol also appears in cosmetics, pharmaceutical, food safety, cannabis databases.