NOAEL Data IARC Group 2A Prop 65 Cosmetic Ingredient

5-Methoxypsoralen

Also known as: 5-19-06-00004, BRN 0019560, EINECS 207-604-5, 6-Hydroxy-4-methoxy-5-benzofuranacrylic acid, gamma-lactone, 5-Methoxy psoralen (+4 more)

CAS 484-20-8

5-Methoxypsoralen (CAS 484-20-8) is a chemical substance; key hazard signal: IARC Group 2A. Key regulatory status: California Proposition 65, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, IARC, CA Prop 65.

View cosmetic safety profile for Bergapten →

Cross-Vertical Regulatory Divergence

5-Methoxypsoralen is classified GHS Danger (H341, H350, H361, H370, H373, H334, H340, H317) in the chemicals database but is restricted in EU cosmetics at max Below 1 mg/kg in sun protection and bronzing products; permitted as natural trace in essences.

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 15 fields

Name

5-Methoxypsoralen

CAS Number

484-20-8

DTXSID

DTXSID1025560

Molecular Formula

C12H8O4

InChI Key

BGEBZHIAGXMEMV-UHFFFAOYSA-N

Monoisotopic Mass

216.042259

Synonyms

5-19-06-00004BRN 0019560EINECS 207-604-56-Hydroxy-4-methoxy-5-benzofuranacrylic acid, gamma-lactone5-Methoxy psoralenUNII-4FVK84C92X4-methoxy-7-furo[3,2-g][1]benzopyranone4-methoxyfuro[3,2-g]chromen-7-one5-methoxypsoralene

IARC Carcinogen Classification

Carcinogenic hazard classification from IARC monograph evaluations.

SOURCE IARC Monographs on the Identification of Carcinogenic Hazards to Humans 1 records

Group	Meaning	Evaluated	Volume
Group 2A	Probably carcinogenic	1987	40, Sup 7

California Proposition 65

California OEHHA listing status and toxicity category.

SOURCE California OEHHA Proposition 65 List 1 records

Chemical	Toxicity Type	Cancer	Developmental	Listed
-	cancer	Yes	No	-

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 3 records

List	Keyword	Source
OEHHA Proposition 65 (3/2019)	STATE OF CALIFORNIA ENVIRONMENTAL PROTECTION AGENCY	OEHHA Proposition 65 List
OEHHA Proposition 65 (1/2023)	California Office of Environmental Health Hazard Assessment	OEHHA Proposition 65 List
Canada; pharmaceutical	DrugBank	DrugBank

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 11 of 11 studies

Value	Unit	Endpoint	Route	Species	Source
SQEcancer	listing type	California Proposition 65 listing	-	-	California Proposition 65
SQEcancer	listing type	California Proposition 65 listing	-	-	California Proposition 65
SQEcancer	listing type	California Proposition 65 listing	-	-	California Proposition 65
SQEcancer	listing type	California Proposition 65 listing	-	-	California Proposition 65
4FVK84C92X	UNII	FDA UNII substance identifier	-	-	openFDA substances
4FVK84C92X	UNII	FDA UNII substance identifier	-	-	openFDA substances
4FVK84C92X	UNII	FDA UNII substance identifier	-	-	openFDA substances
4FVK84C92X	UNII	FDA UNII substance identifier	-	-	openFDA substances
2A	IARC group	IARC carcinogenicity classification	-	-	IARC Monographs
2	unitless	IARC group	-	-	NTP_ICE_cancer
>30000	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral

Showing 11 of 11 studies

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

restricted

Max

Below 1 mg/kg in sun protection and bronzing products; permitted as natural trace in essences

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL BERGAPTEN

ChEMBL Phase

Adverse Events

Bioactivity

View full pharmaceutical profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for 5-Methoxypsoralen?

5-Methoxypsoralen has 11 NOAEL studies in the database. The lowest reported value is cancer listing type. Source: California Proposition 65.

What regulatory lists include 5-Methoxypsoralen?

5-Methoxypsoralen appears on 3 regulatory/inventory lists including OEHHA Proposition 65 (3/2019), OEHHA Proposition 65 (1/2023), Canada; pharmaceutical. Source: EPA CPDat.

Is 5-Methoxypsoralen a carcinogen according to IARC?

5-Methoxypsoralen is classified by IARC as Group 2A — probably carcinogenic to humans (evaluated 1987). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.

Is 5-Methoxypsoralen on the California Proposition 65 list?

Yes, 5-Methoxypsoralen is listed under California Proposition 65 for cancer. Source: California OEHHA Proposition 65.

Is 5-Methoxypsoralen used in cosmetics?

Yes, 5-Methoxypsoralen is also indexed as a cosmetic ingredient under the name Bergapten. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 5-Methoxypsoralen come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, IARC Monographs, California Proposition 65, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does 5-Methoxypsoralen have different safety status in cosmetics vs industrial chemicals?

Is 5-Methoxypsoralen used outside industrial chemicals?

5-Methoxypsoralen also appears in cosmetics, pharmaceutical, cannabis databases.