What is the NOAEL for Guaiazulene?
Guaiazulene has 5 NOAEL studies in the database. The lowest reported value is 2OZ1K9JKQC UNII. Source: openFDA substances.
NOAEL Data
Cosmetic Ingredient
Guaiazulene
Also known as: Azulene, 1,4-dimethyl-7-(1-methylethyl)-, 1,4-Dimethyl-7-(1-methylethyl)Azulene, 1,4-Dimethyl-7-isopropylazulene, 3,8-Dimethyl-5-(2-propyl)azulene, AZULENE, 1,4-DIMETHYL-7-ISOPROPYL- (+14 more)
CAS 489-84-9
Guaiazulene (CAS 489-84-9) is a chemical substance. Key regulatory status: 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.
SOURCE
noael studies public
NOAEL studies
5
SOURCE
chemical inventory jurisdictions
Regulatory lists
2
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
25 fields
Name
Guaiazulene
CAS Number
489-84-9
DTXSID
DTXSID7045996
Molecular Formula
C15H18
InChI Key
FWKQNCXZGNBPFD-UHFFFAOYSA-N
Monoisotopic Mass
198.140851
Synonyms
Azulene, 1,4-dimethyl-7-(1-methylethyl)-1,4-Dimethyl-7-(1-methylethyl)Azulene1,4-Dimethyl-7-isopropylazulene3,8-Dimethyl-5-(2-propyl)azuleneAZULENE, 1,4-DIMETHYL-7-ISOPROPYL-Azulene, 7-isopropyl-1,4-dimethyl-Azulene,1,4-dimethyl-7-(1-methylethyl)-1, 4-Dimethyl-7-isopropylazulene1,4-Dimethyl-7-(1-methyl)-azulene (azulon)1,4-Dimethyl-7-(1-methylethyl)-Azulene1,4-Dimethyl-7-(1-methylethyl)azulene, 9CI1,4-Dimethyl-7-(propan-2-yl)azulene
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
8 records
BiocideFragranceDye
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
2 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| Personal care | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 5 of 5 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 2OZ1K9JKQC | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2OZ1K9JKQC | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2OZ1K9JKQC | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2OZ1K9JKQC | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =1550 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
Showing 5 of 5 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
GUAIAZULEN
ChEMBL Phase
-1
Adverse Events
36
Bioactivity
2
Frequently Asked Questions
What regulatory lists include Guaiazulene?
Guaiazulene appears on 2 regulatory/inventory lists including IFRA Transparency, Personal care. Source: EPA CPDat.
Is Guaiazulene used in cosmetics?
Yes, Guaiazulene is also indexed as a cosmetic ingredient under the name Guaiazulene. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Guaiazulene come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is Guaiazulene used outside industrial chemicals?
Guaiazulene also appears in cosmetics, pharmaceutical databases.