NOAEL Data Cosmetic Ingredient

(2R,5R)-5-Methyl-2-(propan-2-yl)cyclohexanone

Also known as: Cyclohexanone, 5-methyl-2-(1-methylethyl)-, (2R,5R)-rel-, 4-07-00-00087, BRN 3195564, Cyclohexanone, 5-methyl-2-(1-methylethyl)-, (Z)-, EINECS 207-727-4 (+6 more)

CAS 491-07-6

(2R,5R)-5-Methyl-2-(propan-2-yl)cyclohexanone (CAS 491-07-6) is a chemical substance. Key regulatory status: 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.

View cosmetic safety profile for Isomenthone →

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 17 fields

Name

(2R,5R)-5-Methyl-2-(propan-2-yl)cyclohexanone

CAS Number

491-07-6

DTXSID

DTXSID7044475

Molecular Formula

C10H18O

InChI Key

NFLGAXVYCFJBMK-RKDXNWHRSA-N

Monoisotopic Mass

154.135765

Synonyms

Cyclohexanone, 5-methyl-2-(1-methylethyl)-, (2R,5R)-rel-4-07-00-00087BRN 3195564Cyclohexanone, 5-methyl-2-(1-methylethyl)-, (Z)-EINECS 207-727-4EINECS 253-295-5FEMA No. 3460d,l-Isomenthone2-Isopropyl-5-methyl-cyclohexanone1-Methyl-4-isopropyl-3-cyclohexanone, cis-UNII-9WZ3E2G6CL

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 5 records

FragranceFlavouring and nutrient

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 3 records

List	Keyword	Source
IFRA Transparency	IFRA	IFRA
Europe	European Commission	Fl@vis
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)	FDA	United States Food and Drug Administration (FDA)

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 8 of 8 studies

Value	Unit	Endpoint	Route	Species	Source
=26.1	mg/m3	DNEL systemic	inhalation	Human	ToxValDB_GESTIS_DNEL
9WZ3E2G6CL	UNII	FDA UNII substance identifier	-	-	openFDA substances
9WZ3E2G6CL	UNII	FDA UNII substance identifier	-	-	openFDA substances
9WZ3E2G6CL	UNII	FDA UNII substance identifier	-	-	openFDA substances
9WZ3E2G6CL	UNII	FDA UNII substance identifier	-	-	openFDA substances
-	%	Incidence of positive responses	Dermal	Human	NTP_ICE_skin_sensitization
5184	ug/cm2	Induction dose per skin area	Dermal	Human	NTP_ICE_skin_sensitization
3	unitless	Relative reliability score	Dermal	Human	NTP_ICE_skin_sensitization

Showing 8 of 8 studies

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for (2R,5R)-5-Methyl-2-(propan-2-yl)cyclohexanone?

(2R,5R)-5-Methyl-2-(propan-2-yl)cyclohexanone has 8 NOAEL studies in the database. The lowest reported value is 26.1 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.

What regulatory lists include (2R,5R)-5-Methyl-2-(propan-2-yl)cyclohexanone?

(2R,5R)-5-Methyl-2-(propan-2-yl)cyclohexanone appears on 3 regulatory/inventory lists including IFRA Transparency, Europe, food_additive; Substances Added to Food (formerly EAFUS) (2/2019). Source: EPA CPDat.

Is (2R,5R)-5-Methyl-2-(propan-2-yl)cyclohexanone used in cosmetics?

Yes, (2R,5R)-5-Methyl-2-(propan-2-yl)cyclohexanone is also indexed as a cosmetic ingredient under the name Isomenthone. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for (2R,5R)-5-Methyl-2-(propan-2-yl)cyclohexanone come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Is (2R,5R)-5-Methyl-2-(propan-2-yl)cyclohexanone used outside industrial chemicals?

(2R,5R)-5-Methyl-2-(propan-2-yl)cyclohexanone also appears in cosmetics, food safety, cannabis databases.