What is the NOAEL for Ergothioneine?
Ergothioneine has 10 NOAEL studies in the database. The lowest reported value is BDZ3DQM98W UNII. Source: openFDA substances.
NOAEL Data
Cosmetic Ingredient
Ergothioneine
Also known as: (S)-(1-Carboxy-2-(2-mercaptoimidazol-4-yl)ethyl)trimethylammonium hydroxide List Acronyms, 1H-Imidazole-4-ethanaminium, alpha-carboxy-2,3-dihydro-N,N,N-trimethyl-2-thioxo-, hydroxide, inner salt, 1H-Imidazole-4-ethanaminium, alpha-carboxy-2,3-dihydro-N,N,N-trimethyl-2-thioxo-, inner salt, (alphaS)-, 1H-Imidazole-4-ethanaminium, alpha-carboxy-2,3-dihydro-N,N,N-trimethyl-2-thioxo-, inner salt, (S)-, 1H-Imidazole-4-ethaniminium, alpha-carboxy-2,3-dihydro-N,N,N-trimethyl-2-thioxo-, hydroxide, inner salt, (S)- (+2 more)
CAS 497-30-3
Ergothioneine (CAS 497-30-3) is a chemical substance. Key regulatory status: cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat.
SOURCE
noael studies public
NOAEL studies
10
SOURCE
chemical inventory jurisdictions
Regulatory lists
0
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
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DSSTox identifiers
13 fields
Name
Ergothioneine
CAS Number
497-30-3
DTXSID
DTXSID901020082
Molecular Formula
C9H15N3O2S
InChI Key
SSISHJJTAXXQAX-ZETCQYMHSA-N
Monoisotopic Mass
229.088498
Synonyms
(S)-(1-Carboxy-2-(2-mercaptoimidazol-4-yl)ethyl)trimethylammonium hydroxide List Acronyms1H-Imidazole-4-ethanaminium, alpha-carboxy-2,3-dihydro-N,N,N-trimethyl-2-thioxo-, hydroxide, inner salt1H-Imidazole-4-ethanaminium, alpha-carboxy-2,3-dihydro-N,N,N-trimethyl-2-thioxo-, inner salt, (alphaS)-1H-Imidazole-4-ethanaminium, alpha-carboxy-2,3-dihydro-N,N,N-trimethyl-2-thioxo-, inner salt, (S)-1H-Imidazole-4-ethaniminium, alpha-carboxy-2,3-dihydro-N,N,N-trimethyl-2-thioxo-, hydroxide, inner salt, (S)-Ammonium, (1-carboxy-2-(2-mercaptoimidazol-4-yl)ethyl)trimethyl-, hydroxide, inner salt, L-(+)-L-Ergothioneine
Functional Uses
Industrial and product-use categories associated with this substance.
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EPA CPDat
2 records
Antioxidant
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 10 of 10 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| BDZ3DQM98W | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| BDZ3DQM98W | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| BDZ3DQM98W | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| BDZ3DQM98W | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =800 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| =800 | mg/kg bw/day | NOAEL | oral: gavage | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =800 | mg/kg bw/day | NOAEL | oral: gavage | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =725 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_EFSA |
| =725 | mg/kg bw/day | NOEL | oral: feed | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =725 | mg/kg bw/day | NOEL | oral: feed | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
Showing 10 of 10 studies
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
7.5%
Category
active
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL5209630
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
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EFSA / FDA GRAS
1 records
FDA GRAS: FDA has no questions
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
Is Ergothioneine used in cosmetics?
Yes, Ergothioneine is also indexed as a cosmetic ingredient under the name Ergothioneine. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Ergothioneine come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Ergothioneine used outside industrial chemicals?
Ergothioneine also appears in cosmetics, pharmaceutical, food safety, cannabis databases.