NOAEL Data Cosmetic Ingredient

Arbutin

Also known as: 5-17-07-00110, beta-Arbutin, BRN 0089673, EINECS 207-850-3, Hydroquinone beta-D-glucopyranoside (+10 more)

CAS 497-76-7

Arbutin (CAS 497-76-7) is a chemical substance. Key regulatory status: 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, SCCS.

View cosmetic safety profile for Arbutin →

SOURCE noael studies public
NOAEL studies
100
SOURCE chemical inventory jurisdictions
Regulatory lists
3
SOURCE eu clp annex vi
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 21 fields
Name
Arbutin
CAS Number
497-76-7
DTXSID
DTXSID7040152
Molecular Formula
C12H16O7
InChI Key
BJRNKVDFDLYUGJ-RMPHRYRLSA-N
Monoisotopic Mass
272.089603
Synonyms
5-17-07-00110beta-ArbutinBRN 0089673EINECS 207-850-3Hydroquinone beta-D-glucopyranosideHydroquinone-beta-D-glucopyranoside4-Hydroxyphenyl-beta-D-glucopyranosideUNII-C5INA23HXFp-Arbutin(2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-(4-hydroxyphenoxy)oxane-3,4,5-triol(2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-(4-hydroxyphenoxy)tetrahydropyran-3,4,5-triol(2S,3R,4S,5S,6R)-2-(4-hydroxyphenoxy)-6-methylol-tetrahydropyran-3,4,5-triol

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 6 records
AntioxidantSoftener and conditionerBleaching agent

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 3 records
ListKeywordSource
Canada; consumer_product; Substances in Products - Canada (4/2014)Government of CanadaCPCat
Canada; Personal care; Substances in PCP - Canada (4/2014)Government of CanadaCPCat
Canada; pharmaceuticalDrugBankDrugBank

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 100 studies
ValueUnitEndpointRouteSpeciesSource
1%---UnifiedCodex:SCCS_SHADOW:beta.noael_studies
=15mg/kg/day--ratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
=15mg/kg/day--ratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
=20mg/kg/day-oralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
=20mg/kg/day-oralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
20mg/kg bw/d---UnifiedCodex:SCCS_SHADOW:beta.noael_studies
37----UnifiedCodex:SCCS_SHADOW:beta.noael_studies
=74mg/kg/day-dermalratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
=74mg/kg/day-dermalratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
618mg/kg bw/day-oral-UnifiedCodex:SCCS_SHADOW:beta.noael_studies
C5INA23HXFUNIIFDA UNII substance identifier--openFDA substances
C5INA23HXFUNIIFDA UNII substance identifier--openFDA substances
C5INA23HXFUNIIFDA UNII substance identifier--openFDA substances
C5INA23HXFUNIIFDA UNII substance identifier--openFDA substances
=0.0005mg/kg bw/dNOAELdermal-SCCS_vision_codex
=0.0005mg/kg bw/dNOAELdermal-SCCS_vision_codex
=0.0005mg/kg bw/dNOAELdermal-SCCS_vision_codex
=0.0005mg/kg bw/dNOAELdermal-SCCS_vision_codex
=0.00076mg/kg bw/dNOAELdermal-SCCS_vision_codex
=0.00076mg/kg bw/dNOAELdermal-SCCS_vision_codex
=0.00076mg/kg bw/dNOAELdermal-SCCS_vision_codex
=0.00076mg/kg bw/dNOAELdermal-SCCS_vision_codex
=0.522µg/cmNOAELoralratSCCS_vision_codex
=0.522µg/cmNOAELoralratSCCS_vision_codex
=0.522µg/cmNOAELoralratSCCS_vision_codex
=0.522µg/cmNOAELoralratSCCS_vision_codex
=1%NOAEL--SCCS_vision_codex
=1%NOAEL--SCCS_vision_codex
=1%NOAEL--SCCS_vision_codex
=1%NOAEL--SCCS_vision_codex
=15mg/kg/dayNOAELoralratSCCS_vision_codex
=15mg/kg/dayNOAELoralratSCCS_vision_codex
=15mg/kg/dayNOAELoralratSCCS_vision_codex
=15mg/kg/dayNOAELoralratSCCS_vision_codex
=20mg/kg/dayNOAELoralratSCCS_vision_codex
=20mg/kg bw/dNOAELdermal-SCCS_vision_codex
=20mg/kg/dayNOAELoralratSCCS_vision_codex
=20mg/kg/dayNOAELoralratSCCS_vision_codex
=20mg/kg bw/dNOAELdermal-SCCS_vision_codex
=20mg/kg bw/dNOAELdermal-SCCS_vision_codex
=20mg/kg/dayNOAELoralratSCCS_vision_codex
=20mg/kg bw/dNOAELdermal-SCCS_vision_codex
=25mg/kg/dayNOAELoralratSCCS_vision_codex
=25mg/kg/dayNOAELoralratSCCS_vision_codex
=25mg/kg/dayNOAELoralratSCCS_vision_codex
=25mg/kg/dayNOAELoralratSCCS_vision_codex
=37-NOAEL--SCCS_vision_codex
=37-NOAEL--SCCS_vision_codex
=37-NOAEL--SCCS_vision_codex
=37-NOAEL--SCCS_vision_codex

Showing 50 of 100 studies

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE EU SCCS 1 opinions
OpinionDateConclusionMax Conc.Concerns
SCCS/1550/1525 March 2015safe with restrictions7% face creamHydroquinone release potential; beta-arbutin has less concern than alpha-arbutin for hydroquinone release

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
restricted
Max
7% face creams only
Category
active
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL ARBUTIN
ChEMBL Phase
2
Adverse Events
0
Bioactivity
9
View full pharmaceutical profile →

Frequently Asked Questions

What is the NOAEL for Arbutin?

Arbutin has 100 NOAEL studies in the database. The lowest reported value is 0.0005 mg/kg bw/d via dermal. Source: UnifiedCodex:SCCS_SHADOW:beta.noael_studies.

What regulatory lists include Arbutin?

Arbutin appears on 3 regulatory/inventory lists including Canada; consumer_product; Substances in Products - Canada (4/2014), Canada; Personal care; Substances in PCP - Canada (4/2014), Canada; pharmaceutical. Source: EPA CPDat.

Is Arbutin used in cosmetics?

Yes, Arbutin is also indexed as a cosmetic ingredient under the name Arbutin. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Arbutin come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Is Arbutin used outside industrial chemicals?

Arbutin also appears in cosmetics, pharmaceutical databases.