Also known as: Caswell No. 465, EINECS 200-001-8, EPA Pesticide Chemical Code 043001, Formaldehyde, gas, Formalin 40 (+15 more)
CAS 50-00-0
Formaldehyde (CAS 50-00-0) is a chemical substance with GHS signal word Danger; key hazard signal: H350; H341; H330; H302; H314; H317. Key regulatory status: California Proposition 65, REACH registered, 60 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, IARC, ECHA REACH, CA Prop 65, ILO ICSC, OSHA, EPA TRI.
Formaldehyde is prohibited in EU cosmetics at max 2.2% but has active industrial GHS classifications (H350, H341, H330, H302, H314, H317).
CAS, identifiers, formula, and alternate names for the matched substance record.
Carcinogenic hazard classification from IARC monograph evaluations.
| Group | Meaning | Evaluated | Volume |
|---|---|---|---|
| Group 1 | Carcinogenic to humans | 2009 | Sup 7, 62, 88, 100F |
California OEHHA listing status and toxicity category.
| Chemical | Toxicity Type | Cancer | Developmental | Listed |
|---|---|---|---|---|
| - | cancer | Yes | No | - |
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Carc. 1B; Muta. 2; Acute Tox. 2; Acute Tox. 4; Skin Corr. 1B; Skin Sens. 1A | H350; H341; H330; H302; H314; H317 | GHS08; GHS06; GHS05 | Danger |
International Chemical Safety Card hazard and exposure summary.
| Field | Value |
|---|---|
| GHS Signal Word | DANGER |
| GHS Hazard Statements | Extremely flammable gas Fatal if inhaled Causes serious eye irritation May cause cancer if inhaled May cause an allergic skin reaction May cause respiratory irritation |
| Short-term Effects | The substance is severely irritating to the eyes and respiratory tract. Inhalation of high concentrations may cause lung oedema, but only after initial corrosive effects on the eyes and the upper respiratory tract have become manifest. |
| Long-term Effects | Repeated or chronic inhalation of the vapour may cause chronic inflammation of the upper respiratory tract. Repeated or prolonged contact may cause skin sensitization. This substance is carcinogenic to humans. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation. |
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| OSHA | TWA | 0.75 ppm [0.5 ppm Action Level] | 0.75 | - | N |
| OSHA | STEL | 2 ppm | 2 | - | N |
| NIOSH | TWA | 0.016 ppm | 0.016 | - | Y |
| NIOSH | CEILING | 0.1 ppm [15 minutes] | 0.1 | - | Y |
| ACGIH | TWA | 0.1 ppm [2016] | 0.1 | - | N |
| ACGIH | STEL | 0.3 ppm [2016] | 0.3 | - | N |
| CAL/OSHA | TWA | 0.75 ppm [0.50 ppm Action Level] | 0.75 | - | N |
| CAL/OSHA | STEL | 2 ppm | 2 | - | N |
| NIOSH | IDLH | 20 ppm | 20 | - | - |
| AIHA | ERPG-1 | 1 ppm | 1 | - | - |
| AIHA | ERPG-2 | 10 ppm | 10 | - | - |
| AIHA | ERPG-3 | 40 ppm | 40 | - | - |
| OSHA | TWA | 0.75 ppm [0.5 ppm Action Level] | 0.75 | - | N |
| OSHA | STEL | 2 ppm | 2 | - | N |
| NIOSH | TWA | 0.016 ppm | 0.016 | - | N |
| NIOSH | CEILING | 0.1 ppm [15 minutes] | 0.1 | - | N |
| ACGIH | TWA | 0.1 ppm [2016] | 0.1 | - | N |
| ACGIH | STEL | 0.3 ppm [2016] | 0.3 | - | N |
| CAL/OSHA | TWA | 0.75 ppm [0.50 ppm Action Level] | 0.75 | - | N |
| CAL/OSHA | STEL | 2 ppm | 2 | - | N |
| NIOSH | IDLH | 20 ppm | 20 | - | - |
| AIHA | ERPG-1 | 1 ppm | 1 | - | - |
| AIHA | ERPG-2 | 10 ppm | 10 | - | - |
| AIHA | ERPG-3 | 40 ppm | 40 | - | - |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| drinking_water; Europe; manufacturing; plastic_additive | Belgaqua | CPCat |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | California Department of Pesticide Regulation | State of California |
| active_ingredient; Europe; Pesticides | European Commission | CPCat |
| Cons electronics mech appliances and machinery; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; Cons electronics mech appliances and machinery; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; Cons electronics mech appliances and machinery; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| Cons electronics mech appliances and machinery; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Furniture and Furnishings | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Other indirect contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Furniture and Furnishings | Danish Environmental Protection Agency | Danish EPA |
| air; Construction and building materials; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Furniture and Furnishings | Danish Environmental Protection Agency | Danish EPA |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| consumer_product; detected | Elsevier | CPCat |
| Europe; Personal care - nails - nail polish | Danish Environmental Protection Agency | Danish EPA |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 1 | % | - | inhalation | rat | Regulatory source |
| 1 | ppm | - | inhalation | rat | Regulatory source |
| 2 | ppm | - | inhalation | rat | Regulatory source |
| 10 | mg/kg bw/day | - | dermal | - | Regulatory source |
| =0.5403 | mg/m3 | BMCL (05) | inhalation | Human | ToxValDB Cal OEHHA REL derivations |
| 5.14 | ug/mL | CD54, EC200 | Dermal | - | NTP ICE skin sensitization |
| 5.2 | ug/mL | CD54, EC200 | Dermal | - | NTP ICE skin sensitization |
| 0.634 | ug/mL | CD86, EC120 | Dermal | - | NTP ICE skin sensitization |
| 1.6 | ug/mL | CD86, EC150 | Dermal | - | NTP ICE skin sensitization |
| 4.3 | ug/mL | CD86, EC150 | Dermal | - | NTP ICE skin sensitization |
| 5.74 | ug/mL | CD86, EC150 | Dermal | - | NTP ICE skin sensitization |
| 5.8 | ug/mL | CV75 | Dermal | - | NTP ICE skin sensitization |
| 23.3 | ug/mL | CV75 | Dermal | - | NTP ICE skin sensitization |
| SQE40 | ug/day | California Proposition 65 NSRL | - | - | California Proposition 65 |
| SQEcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| 0.1285 | % | Concentration, 5% incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 0.4116 | % | Concentration, 5% incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 0.9768 | % | Concentration, 5% incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 1.202 | % | Concentration, 5% incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 2.359 | % | Concentration, 5% incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 0.0925 | % | Concentration, one positive response | Dermal | Human | NTP ICE skin sensitization |
| 0.1028 | % | Concentration, one positive response | Dermal | Human | NTP ICE skin sensitization |
| 0.222 | % | Concentration, one positive response | Dermal | Human | NTP ICE skin sensitization |
| 0.4625 | % | Concentration, one positive response | Dermal | Human | NTP ICE skin sensitization |
| =0.375 | mg/m3 | DNEL local | inhalation | Human | ToxValDB GESTIS DNEL |
| =9 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| 30.5 | % | Depletion Cys | Dermal | - | NTP ICE skin sensitization |
| 36.6 | % | Depletion Cys | Dermal | - | NTP ICE skin sensitization |
| 36.7 | % | Depletion Cys | Dermal | - | NTP ICE skin sensitization |
| 37.3 | % | Depletion Cys | Dermal | - | NTP ICE skin sensitization |
| 40.6 | % | Depletion Cys | Dermal | - | NTP ICE skin sensitization |
| 44.2 | % | Depletion Cys | Dermal | - | NTP ICE skin sensitization |
| 44.7 | % | Depletion Cys | Dermal | - | NTP ICE skin sensitization |
| 48.6 | % | Depletion Cys | Dermal | - | NTP ICE skin sensitization |
| 49.6 | % | Depletion Cys | Dermal | - | NTP ICE skin sensitization |
| 51.4 | % | Depletion Cys | Dermal | - | NTP ICE skin sensitization |
| 54.8 | % | Depletion Cys | Dermal | - | NTP ICE skin sensitization |
| 60.4 | % | Depletion Cys | Dermal | - | NTP ICE skin sensitization |
| 0.3 | % | Depletion Lys | Dermal | - | NTP ICE skin sensitization |
| 1.3 | % | Depletion Lys | Dermal | - | NTP ICE skin sensitization |
| 1.8 | % | Depletion Lys | Dermal | - | NTP ICE skin sensitization |
| 2 | % | Depletion Lys | Dermal | - | NTP ICE skin sensitization |
| 2.3 | % | Depletion Lys | Dermal | - | NTP ICE skin sensitization |
| 2.4 | % | Depletion Lys | Dermal | - | NTP ICE skin sensitization |
| 2.5 | % | Depletion Lys | Dermal | - | NTP ICE skin sensitization |
| 3.2 | % | Depletion Lys | Dermal | - | NTP ICE skin sensitization |
| 3.6 | % | Depletion Lys | Dermal | - | NTP ICE skin sensitization |
| 3.8 | % | Depletion Lys | Dermal | - | NTP ICE skin sensitization |
| 4.2 | % | Depletion Lys | Dermal | - | NTP ICE skin sensitization |
| 11.2 | % | Depletion Lys | Dermal | - | NTP ICE skin sensitization |
Showing 50 of 72 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Formaldehyde | 200-001-8 | ECHA overview → |
TRI hazard and reporting flags for the matched chemical.
| Chemical | Category | Flags |
|---|---|---|
| Formaldehyde | - | - |
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS pharmaceutical records from drug and bioactivity sources.
Same-CAS food additive, ADI, and GRAS records where available.
ADI: 0.15 mg/kg bw
View full food safety profile →Same-CAS cannabis compliance and lab records where available.
1 cannabis record found in efsa substances.
View full cannabis profile →Formaldehyde (CAS 50-00-0) is classified under EU CLP Annex VI as Carc. 1B; Muta. 2; Acute Tox. 2; Acute Tox. 4; Skin Corr. 1B; Skin Sens. 1A with signal word Danger. Hazard statements: H350; H341; H330; H302; H314; H317. Source: EU CLP Annex VI (ECHA).
Formaldehyde has 72 NOAEL studies in the database. The lowest reported value is 0.0925 % via Dermal in Human. Source: NTP ICE skin sensitization.
Formaldehyde appears on 20 regulatory/inventory lists including drinking_water; Europe; manufacturing; plastic_additive, active_ingredient; Pesticides, active_ingredient; Europe; Pesticides, and 17 more. Source: EPA CPDat.
Formaldehyde is classified by IARC as Group 1 — carcinogenic to humans (evaluated 2009). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.
Yes, Formaldehyde is listed under California Proposition 65 for cancer. Source: California OEHHA Proposition 65.
Occupational exposure limits for Formaldehyde are set by OSHA, NIOSH, ACGIH. 24 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Yes, Formaldehyde is also indexed as a cosmetic ingredient under the name Formaldehyde. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, EPA DSSTox, IARC Monographs, ECHA REACH, California Proposition 65, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, EPA Toxics Release Inventory, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Formaldehyde is prohibited in EU cosmetics at max 2.2% but has active industrial GHS classifications (H350, H341, H330, H302, H314, H317).
Formaldehyde also appears in cosmetics, pharmaceutical, food safety, cannabis databases.