What is the NOAEL for L-Ascorbic acid?
L-Ascorbic acid has 39 NOAEL studies in the database. The lowest reported value is PQ6CK8PD0R UNII. Source: openFDA substances.
NOAEL Data
Cosmetic Ingredient
L-Ascorbic acid
Also known as: Ascorbic acid (vitamin C), Ascorbic acid, L-Ascorbate, Caswell No. 061B, EINECS 200-066-2 (+15 more)
CAS 50-81-7
L-Ascorbic acid (CAS 50-81-7) is a chemical substance. Key regulatory status: 17 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ILO ICSC.
SOURCE
NOAEL studies
NOAEL studies
39
SOURCE
Chemical inventory jurisdictions
Regulatory lists
17
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
25 fields
Name
L-Ascorbic acid
CAS Number
50-81-7
Molecular Formula
C6H8O6
InChI Key
CIWBSHSKHKDKBQ-JLAZNSOCSA-N
Monoisotopic Mass
176.032088
Synonyms
Ascorbic acid (vitamin C)Ascorbic acidL-AscorbateCaswell No. 061BEINECS 200-066-2FEMA No. 2109Hex-2-enonic acid gamma-lactone, L-threo-NCI-C54808L-threo-Hex-2-enonic acid, gamma-lactoneAcidum ascorbicumUNII-PQ6CK8PD0R(+)-Sodium L-ascorbate
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
WHO/JECFA
1 records
| Field | Value |
|---|---|
| GHS Hazard Statements | No hazard classification according to GHS criteria |
| Routes of Exposure | The substance can be absorbed into the body by inhalation of its aerosol and by ingestion. |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
43 records
AntioxidantpH regulating agentFragranceDeodorizerSoftener and conditionerPreservativeFlavouring and nutrientPharmaceuticalProcessing aids not otherwise specifiedBiocideChelating agentThickening agentDyeFiller
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
17 records
| List | Keyword | Source |
|---|---|---|
| pharmaceutical | US International Trade Commission | CPCat |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - general moisturizing - hand/body lotion | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| inert_ingredient; Pesticides | EPA | CPCat |
| active_ingredient; Europe; Pesticides | European Commission | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| Europe; supplements | EU | CPCat |
| Europe; food_additive; supplements | EU | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| Europe; supplements | EU | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 39 of 39 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| PQ6CK8PD0R | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.26 | fraction | Fu | - | Human | NTP ICE adme parameters |
| >5000 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =1.190e+4 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =25 | mg/kg bw/day | LEL | injection | Rat | ToxValDB Uterotrophic Hershberger DB |
| =1250 | mg/kg bw/day | LEL | oral | Rat | ToxValDB ToxRefDB |
| =1250 | mg/kg bw/day | LEL | oral | rat (fischer; Fischer 344) | EPA ToxRefDB v3 |
| =1458 | mg/kg bw/day | LEL | oral | Rat | ToxValDB ToxRefDB |
| =1458 | mg/kg bw/day | LEL | oral | rat (fischer; Fischer 344) | EPA ToxRefDB v3 |
| >2560 | mg/kg bw/day | LEL | oral | Rat | ToxValDB ToxRefDB |
| >2560 | mg/kg bw/day | LEL | oral | rat (fischer; Fischer 344) | EPA ToxRefDB v3 |
| =7186 | mg/kg bw/day | LEL | oral | Mouse | ToxValDB ToxRefDB |
| =7186 | mg/kg bw/day | LEL | oral | mouse (b6c3f1; B6C3F1) | EPA ToxRefDB v3 |
| =1.500e+4 | mg/kg bw/day | LEL | oral | Mouse | ToxValDB ToxRefDB |
| =1.500e+4 | mg/kg bw/day | LEL | oral | mouse (b6c3f1; B6C3F1) | EPA ToxRefDB v3 |
| =5000 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB ToxRefDB |
| =5000 | mg/kg bw/day | LOAEL | oral | rat (fischer; Fischer 344) | EPA ToxRefDB v3 |
| >1.279e+4 | mg/kg bw/day | LOAEL | oral | Mouse | ToxValDB ToxRefDB |
| >1.279e+4 | mg/kg bw/day | LOAEL | oral | mouse (b6c3f1; B6C3F1) | EPA ToxRefDB v3 |
| =100 | mg/kg bw/day | LOEL | oral | Rat | ToxValDB ECOTOX |
| 0 | unitless | Model Score | - | - | NTP ICE endocrine |
| >0 | mg/kg bw/day | NEL | oral | rat (fischer; Fischer 344) | EPA ToxRefDB v3 |
| =3750 | mg/kg bw/day | NEL | oral | Mouse | ToxValDB ToxRefDB |
| =3750 | mg/kg bw/day | NEL | oral | mouse (b6c3f1; B6C3F1) | EPA ToxRefDB v3 |
| =7500 | mg/kg bw/day | NEL | oral | Mouse | ToxValDB ToxRefDB |
| =7500 | mg/kg bw/day | NEL | oral | mouse (b6c3f1; B6C3F1) | EPA ToxRefDB v3 |
| =2500 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB ToxRefDB |
| =2500 | mg/kg bw/day | NOAEL | oral | rat (fischer; Fischer 344) | EPA ToxRefDB v3 |
| =5 | % | NOEL | oral | Rat | ToxValDB ECOTOX |
| =10 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB ECOTOX |
| =20 | mM | NOEL | environmental | Rat | ToxValDB ECOTOX |
| =40 | mg/kg bw/day | NOEL | injection | Mouse | ToxValDB ECOTOX |
| =60 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB ECOTOX |
| =100 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB ECOTOX |
| =120 | mg/kg bw/day | NOEL | injection | Rat | ToxValDB ECOTOX |
| =200 | mg/kg bw/day | NOEL | oral | Mouse | ToxValDB ECOTOX |
| =2000 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB ECOTOX |
| <2400 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB HESS |
| 5.000e+4 | ppm | Top dose | Dosed feed | Mouse | NTP ICE cancer |
Showing 39 of 39 studies
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
antioxidant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
ASCORBIC ACID
ChEMBL Phase
4
Adverse Events
7867
Bioactivity
15
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA
1 records
E300 — ADI: NOT SPECIFIED mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include L-Ascorbic acid?
L-Ascorbic acid appears on 12 regulatory/inventory lists including pharmaceutical, active_ingredient; Europe; Pesticides, children; Europe; Personal care, and 9 more. Source: EPA CPDat.
Is L-Ascorbic acid used in cosmetics?
Yes, L-Ascorbic acid is also indexed as a cosmetic ingredient under the name Ascorbic Acid. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for L-Ascorbic acid come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is L-Ascorbic acid used outside industrial chemicals?
L-Ascorbic acid also appears in cosmetics, pharmaceutical, food safety, cannabis databases.