NOAEL Data REACH Registered Cosmetic Ingredient

Isovaleric acid

Also known as: 3-Methylbutanoic acid, 4-02-00-00895, BRN 1098522, Butyric acid, 3-methyl-, EINECS 207-975-3 (+15 more)

CAS 503-74-2

Isovaleric acid (CAS 503-74-2) is a chemical substance. Key regulatory status: REACH registered, 6 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for Isovaleric Acid →

Cross-Vertical Regulatory Divergence

Isovaleric acid is classified GHS Danger (H314, H318) in the chemicals database but is allowed in EU cosmetics.

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 26 fields

Name

Isovaleric acid

CAS Number

503-74-2

DTXSID

DTXSID5029182

Molecular Formula

C5H10O2

InChI Key

GWYFCOCPABKNJV-UHFFFAOYSA-N

Monoisotopic Mass

102.06808

Synonyms

3-Methylbutanoic acid4-02-00-00895BRN 1098522Butyric acid, 3-methyl-EINECS 207-975-3FEMA No. 3102FEMA Number: 3102Isobutyl formic acidIsovalerianicbeta-Methylbutyric acidKyselina isovalerovaUNII-1BR7X184L5

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 6 records

FragranceNo specific technical functionFlavouring and nutrient

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 6 records

List	Keyword	Source
Europe	European Commission	Fl@vis
Australia; Food and drug - smoking-related products	New Zealand ESR	CPCat
IFRA Transparency	IFRA	IFRA
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)	FDA	United States Food and Drug Administration (FDA)
Canada; pharmaceutical	DrugBank	DrugBank
consumer_product	P&G	Proctor & Gamble

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 26 of 26 studies

Value	Unit	Endpoint	Route	Species	Source
1BR7X184L5	UNII	FDA UNII substance identifier	-	-	openFDA substances
1BR7X184L5	UNII	FDA UNII substance identifier	-	-	openFDA substances
1BR7X184L5	UNII	FDA UNII substance identifier	-	-	openFDA substances
-	%	Incidence of positive responses	Dermal	Human	NTP_ICE_skin_sensitization
675	ug/cm2	Induction dose per skin area	Dermal	Human	NTP_ICE_skin_sensitization
=2000	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=2500	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
<3200	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=50	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_EFSA
=50	mg/kg bw/day	NOAEL	oral: gavage	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
=125	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_EFSA
=125	mg/kg bw/day	NOAEL	oral: gavage	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
>219	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_EFSA
>219	mg/kg bw/day	NOAEL	oral: unspecified	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
>300	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_EFSA
>300	mg/kg bw/day	NOAEL	oral: feed	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
=340	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_EFSA
=340	mg/kg bw/day	NOAEL	oral: drinking water	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
>1000	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_EFSA
>1000	mg/kg bw/day	NOAEL	oral: gavage	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
>1450	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_EFSA
>1450	mg/kg bw/day	NOAEL	oral: drinking water	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
2500	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB
>2500	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_EFSA
>2500	mg/kg bw/day	NOAEL	oral: feed	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
3	unitless	Relative reliability score	Dermal	Human	NTP_ICE_skin_sensitization

Showing 26 of 26 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	Isovaleric acid	207-975-3	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL 3-METHYLBUTANOIC ACID

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for Isovaleric acid?

Isovaleric acid has 26 NOAEL studies in the database. The lowest reported value is 1BR7X184L5 UNII. Source: openFDA substances.

What regulatory lists include Isovaleric acid?

Isovaleric acid appears on 6 regulatory/inventory lists including Europe, Australia; Food and drug - smoking-related products, IFRA Transparency, and 3 more. Source: EPA CPDat.

Is Isovaleric acid used in cosmetics?

Yes, Isovaleric acid is also indexed as a cosmetic ingredient under the name Isovaleric Acid. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Isovaleric acid come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does Isovaleric acid have different safety status in cosmetics vs industrial chemicals?

Isovaleric acid is classified GHS Danger (H314, H318) in the chemicals database but is allowed in EU cosmetics.

Is Isovaleric acid used outside industrial chemicals?

Isovaleric acid also appears in cosmetics, pharmaceutical, cannabis databases.