What is the NOAEL for Fluorescein sodium?
Fluorescein sodium has 14 NOAEL studies in the database. The lowest reported value is 93X55PE38X UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Fluorescein sodium
Also known as: C.I. Acid yellow 73, Spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, 3',6'-dihydroxy-, disodium salt, Calcocid uranine B4315, 9-o-Carboxyphenyl-6-hydroxy-3-isoxanthone, disodium salt, Disodium 6-hydroxy-3-oxo-9-xanthene-o-benzoate (+12 more)
CAS 518-47-8
Fluorescein sodium (CAS 518-47-8) is a chemical substance. Key regulatory status: REACH registered, 8 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
14
SOURCE
chemical inventory jurisdictions
Regulatory lists
8
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
23 fields
Name
Fluorescein sodium
CAS Number
518-47-8
DTXSID
DTXSID9025328
Molecular Formula
C20H12O5.2Na
InChI Key
RGPLGPBQJOQFJS-UHFFFAOYSA-L
Monoisotopic Mass
378.048012
Synonyms
C.I. Acid yellow 73Spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, 3',6'-dihydroxy-, disodium saltCalcocid uranine B43159-o-Carboxyphenyl-6-hydroxy-3-isoxanthone, disodium saltDisodium 6-hydroxy-3-oxo-9-xanthene-o-benzoateEINECS 208-253-0Fluorescein, solubleFluor-I-strip A.T.FundusceinNCI-C54706Sodium salt of hydroxy-o-carboxy-phenyl-fluoroneSoluble fluoresceine
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
35 records
Dye
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
8 records
| List | Keyword | Source |
|---|---|---|
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - specialized bath products - bath salts | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| pharmaceutical | FDA | United States Food and Drug Administration (FDA) |
| Personal care | FDA | United States Food and Drug Administration (FDA) |
| CEDI | FDA | United States Food and Drug Administration (FDA) |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 14 of 14 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 93X55PE38X | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 93X55PE38X | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 93X55PE38X | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 93X55PE38X | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| concept | identifier | FDA UNII substance identifier | - | - | openFDA substances |
| concept | identifier | FDA UNII substance identifier | - | - | openFDA substances |
| concept | identifier | FDA UNII substance identifier | - | - | openFDA substances |
| concept | identifier | FDA UNII substance identifier | - | - | openFDA substances |
| =6721 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =250 | mg/kg bw/day | NOAEL | oral | Rabbit | ToxValDB_ECHA_IUCLID |
| =500 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =1500 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =2241.4 | mg/kg bw/day | NOAEL | injection | Rabbit | ToxValDB_ECHA_IUCLID |
| =250 | mg/kg bw/day | NOEL | oral | Rabbit | ToxValDB_ECHA_IUCLID |
Showing 14 of 14 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Disodium 2-(3-oxo-6-oxidoxanthen-9-yl)benzoate | 208-253-0 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
6%
Category
Colorants
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
FLUORESCEIN SODIUM
ChEMBL Phase
4
Adverse Events
31
Bioactivity
4
Frequently Asked Questions
What regulatory lists include Fluorescein sodium?
Fluorescein sodium appears on 6 regulatory/inventory lists including children; Europe; Personal care, children; Europe; Personal care - specialized bath products - bath salts, pharmaceutical, and 3 more. Source: EPA CPDat.
Is Fluorescein sodium used in cosmetics?
Yes, Fluorescein sodium is also indexed as a cosmetic ingredient under the name CI 45350. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Fluorescein sodium come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is Fluorescein sodium used outside industrial chemicals?
Fluorescein sodium also appears in cosmetics, pharmaceutical databases.