What is the NOAEL for Tetrasodium glutamate diacetate?
Tetrasodium glutamate diacetate has 17 NOAEL studies in the database. The lowest reported value is 0.2 mg/kg bw in Consumers. Source: EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Tetrasodium glutamate diacetate
Also known as: L-Glutamic acid, N,N-bis(carboxymethyl)-, sodium salt (1:4), Tetrasodium N,N-Bis(carboxymethyl)-L-glutamate, EINECS 257-573-7, UNII-5EHL50I4MY
CAS 51981-21-6
Tetrasodium glutamate diacetate (CAS 51981-21-6) is a chemical substance. Key regulatory status: REACH registered, 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
View cosmetic safety profile for Tetrasodium Glutamate Diacetate →
SOURCE
noael studies public
NOAEL studies
17
SOURCE
chemical inventory jurisdictions
Regulatory lists
1
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
10 fields
Name
Tetrasodium glutamate diacetate
CAS Number
51981-21-6
DTXSID
DTXSID2052158
Molecular Formula
C9H13NO8.4Na
InChI Key
UZVUJVFQFNHRSY-OUTKXMMCSA-J
Monoisotopic Mass
355.023194
Synonyms
L-Glutamic acid, N,N-bis(carboxymethyl)-, sodium salt (1:4)Tetrasodium N,N-Bis(carboxymethyl)-L-glutamateEINECS 257-573-7UNII-5EHL50I4MY
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
55 records
Chelating agentCleaning agentSolvent
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
1 records
| List | Keyword | Source |
|---|---|---|
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 17 of 17 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =0.2 | mg/kg bw | ADI | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| =0.2 | mg/kg bw | ADI | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| =7.3 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 5EHL50I4MY | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 5EHL50I4MY | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 5EHL50I4MY | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 5EHL50I4MY | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >2000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =10000 | mg/kg bw/day | LEL | oral | Chicken | ToxValDB_EFSA |
| =20 | mg/kg bw/day | NOAEL | oral | Rabbit | ToxValDB_EFSA |
| =20 | mg/kg bw/day | NOAEL | oral: gavage | Rabbit | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =20 | mg/kg bw/day | NOAEL | oral: gavage | Rabbit | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| >=300 | mg/kg bw/day | NOAEL | oral | Rabbit | ToxValDB_ECHA_IUCLID |
| >=1000 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =5000 | ppm | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| >=15000 | ppm | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =1 | mg/L | NOEC | inhalation | Eel Order | ToxValDB_EFSA |
Showing 17 of 17 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Tetrasodium N,N-bis(carboxylatomethyl)-L-glutamate | 257-573-7 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed_with_terms
Conditions
Specific information requirements: Obligations to provide information apply. You must tell us within 28 days if the circumstances of your importation or manufacture (introduction) are different to those in our assessment.
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
0.05–0.30%
Category
chelating
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Tetrasodium glutamate diacetate?
Tetrasodium glutamate diacetate appears on 1 regulatory/inventory list including SCIL (9/2019). Source: EPA CPDat.
Is Tetrasodium glutamate diacetate used in cosmetics?
Yes, Tetrasodium glutamate diacetate is also indexed as a cosmetic ingredient under the name Tetrasodium Glutamate Diacetate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Tetrasodium glutamate diacetate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Tetrasodium glutamate diacetate used outside industrial chemicals?
Tetrasodium glutamate diacetate also appears in cosmetics, cannabis databases.