What is the NOAEL for Kaempferol?
Kaempferol has 18 NOAEL studies in the database. The lowest reported value is 0 unitless. Source: NTP ICE endocrine.
NOAEL Data
IARC Group 3
Cosmetic Ingredient
Kaempferol
Also known as: 5-18-05-00251, BRN 0304401, EINECS 208-287-6, Kaemferol, Pelargidenolon 1497 (+9 more)
CAS 520-18-3
Kaempferol (CAS 520-18-3) is a chemical substance; key hazard signal: IARC Group 3. Key regulatory status: 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, IARC.
Cross-Vertical Regulatory Divergence
Kaempferol is classified GHS Danger (H301, H341) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
NOAEL studies
NOAEL studies
18
SOURCE
Chemical inventory jurisdictions
Regulatory lists
2
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
20 fields
Name
Kaempferol
CAS Number
520-18-3
DTXSID
DTXSID7020768
Molecular Formula
C15H10O6
InChI Key
IYRMWMYZSQPJKC-UHFFFAOYSA-N
Monoisotopic Mass
286.047738
Synonyms
5-18-05-00251BRN 0304401EINECS 208-287-6KaemferolPelargidenolon 14973,5,7,4'-TetrahydroxyflavoneUNII-731P2LE49E3,4',5,7-Tetrahydroxy-Flavone (7CI,8CI)3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one4H-1-Benzopyran-4-one, 3,5,7-trihydroxy-2- (4-hydroxyphenyl)-Kampferol
IARC Carcinogen Classification
Carcinogenic hazard classification from IARC monograph evaluations.
SOURCE
IARC Monographs on the Identification of Carcinogenic Hazards to Humans
1 records
| Group | Meaning | Evaluated | Volume |
|---|---|---|---|
| Group 3 | Not classifiable | 1987 | 31, Sup 7 |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
2 records
Softener and conditionerAntioxidant
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
2 records
| List | Keyword | Source |
|---|---|---|
| Canada; consumer_product; Substances in Products - Canada (4/2014) | Government of Canada | CPCat |
| Canada; pharmaceutical | DrugBank | DrugBank |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 18 of 18 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 4.03455966977048 | uM | AC50 | - | - | NTP ICE endocrine |
| 9700 | nM | AC50/EC50/IC50 | - | - | NTP ICE endocrine |
| 16000 | nM | AC50/EC50/IC50 | - | - | NTP ICE endocrine |
| 2.58939477160506 | uM | ACC | - | - | NTP ICE endocrine |
| 71 | uL/min/10^6 cells | Clint | - | Rat | NTP ICE adme parameters |
| 95.7 | uL/min/10^6 cells | Clint | - | Human | NTP ICE adme parameters |
| 3990 | nM | EC50 | - | - | NTP ICE endocrine |
| 731P2LE49E | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 731P2LE49E | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 731P2LE49E | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 731P2LE49E | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.0144 | fraction | Fu | - | Rat | NTP ICE adme parameters |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | unitless | IARC group | - | - | NTP ICE cancer |
| 0.1 | nM | LEL | - | - | NTP ICE endocrine |
| - | unitless | Model Score | - | - | NTP ICE endocrine |
| 0.252 | unitless | Model Score | - | - | NTP ICE endocrine |
| 1210 | nM | PC50 | - | - | NTP ICE endocrine |
Showing 18 of 18 studies
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Other
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
KAEMPFEROL
ChEMBL Phase
1
Adverse Events
0
Bioactivity
11
Frequently Asked Questions
What regulatory lists include Kaempferol?
Kaempferol appears on 2 regulatory/inventory lists including Canada; consumer_product; Substances in Products - Canada (4/2014), Canada; pharmaceutical. Source: EPA CPDat.
Is Kaempferol a carcinogen according to IARC?
Kaempferol is classified by IARC as Group 3 — not classifiable as to its carcinogenicity to humans (evaluated 1987). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.
Is Kaempferol used in cosmetics?
Yes, Kaempferol is also indexed as a cosmetic ingredient under the name Kaempferol Cosmetic. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Kaempferol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, IARC Monographs, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does Kaempferol have different safety status in cosmetics vs industrial chemicals?
Kaempferol is classified GHS Danger (H301, H341) in the chemicals database but is allowed in EU cosmetics.
Is Kaempferol used outside industrial chemicals?
Kaempferol also appears in cosmetics, pharmaceutical databases.