What is the NOAEL for Diosmin?
Diosmin has 4 NOAEL studies in the database. The lowest reported value is 7QM776WJ5N UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Diosmin
Also known as: EINECS 208-289-7, Diosmine, Diosminum, Barosmin, Diosmetin-7-O-rutinoside (+15 more)
CAS 520-27-4
Diosmin (CAS 520-27-4) is a chemical substance. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
4
SOURCE
chemical inventory jurisdictions
Regulatory lists
3
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
Diosmin
CAS Number
520-27-4
DTXSID
DTXSID4045892
Molecular Formula
C28H32O15
InChI Key
GZSOSUNBTXMUFQ-YFAPSIMESA-N
Monoisotopic Mass
608.17412
Synonyms
EINECS 208-289-7DiosmineDiosminumBarosminDiosmetin-7-O-rutinoside3',5,7-Trihydroxy-4'-methoxyflavone-7-(6-O-(-deoxy-alpha-L-mannopyraonsyl)-beta-D-glucopyranoside5-Hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-((6-O-alpha-L-rhamnopyranosyl-beta-D-glycopyranosyl)oxy)-4-chromenonDiosmilDiovenorFlebostenVenosmineVen-Detrex
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
1 records
Antioxidant
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| pharmaceutical | US International Trade Commission | CPCat |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 4 of 4 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 7QM776WJ5N | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 7QM776WJ5N | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 7QM776WJ5N | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 7QM776WJ5N | UNII | FDA UNII substance identifier | - | - | openFDA substances |
Showing 4 of 4 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Diosmin | 208-289-7 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Antioxidant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
DIOSMIN
ChEMBL Phase
4
Adverse Events
1854
Bioactivity
7
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
1 food-safety record found.
View full food safety profile →Frequently Asked Questions
What regulatory lists include Diosmin?
Diosmin appears on 2 regulatory/inventory lists including pharmaceutical, Canada; pharmaceutical. Source: EPA CPDat.
Is Diosmin used in cosmetics?
Yes, Diosmin is also indexed as a cosmetic ingredient under the name Diosmin. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Diosmin come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.
Is Diosmin used outside industrial chemicals?
Diosmin also appears in cosmetics, pharmaceutical, food safety databases.