NOAEL Data Cosmetic Ingredient

1,2,4-Benzenetriol

Also known as: 4-06-00-07338, BRN 2042863, EINECS 208-575-1, Hydroquinone, hydroxy-, Hydroxyquinol (+3 more)

CAS 533-73-3

1,2,4-Benzenetriol (CAS 533-73-3) is a chemical substance. Key regulatory status: cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, SCCS.

View cosmetic safety profile for 1,2,4-Trihydroxybenzene →

SOURCE NOAEL studies
NOAEL studies
22
SOURCE Chemical inventory jurisdictions
Regulatory lists
0
SOURCE EU CLP Annex VI
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 14 fields
Name
1,2,4-Benzenetriol
CAS Number
533-73-3
DTXSID
DTXSID3040930
Molecular Formula
C6H6O3
InChI Key
GGNQRNBDZQJCCN-UHFFFAOYSA-N
Monoisotopic Mass
126.031694
Synonyms
4-06-00-07338BRN 2042863EINECS 208-575-1Hydroquinone, hydroxy-HydroxyquinolOxyhydroquinoneOxyhydrochinonUNII-173O8B04RD

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 4 records
Dye

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 22 of 22 studies
ValueUnitEndpointRouteSpeciesSource
50mg/kg bw/day---Regulatory source
50mg/kg bw/day-oralratRegulatory source
50mg/kg bw/day---Regulatory source
1452----Regulatory source
173O8B04RDUNIIFDA UNII substance identifier--openFDA substances
173O8B04RDUNIIFDA UNII substance identifier--openFDA substances
173O8B04RDUNIIFDA UNII substance identifier--openFDA substances
173O8B04RDUNIIFDA UNII substance identifier--openFDA substances
50mg/kg bw/dayLOAELoralratCOSMOS DB
=50mg/kg bw/dayNOAEL--SCCS Opinion
=50mg/kg bw/dayNOAEL--SCCS Opinion
=50mg/kg bw/dayNOAEL--SCCS Opinion
=50mg/kg bw/dayNOAEL--SCCS Opinion
=50mg/kg bw/dayNOAEL--SCCS Opinion
=50mg/kg bw/dayNOAEL--SCCS Opinion
=50mg/kg bw/dayNOAEL--SCCS Opinion
=50mg/kg bw/dayNOAEL--SCCS Opinion
=1452-NOAEL--SCCS Opinion
=1452-NOAEL--SCCS Opinion
=1452-NOAEL--SCCS Opinion
=1452-NOAEL--SCCS Opinion
50mg/kg bw/daydermal absorptionoralratRegulatory source

Showing 22 of 22 studies

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE SCCS Opinion 3 opinions
OpinionDateConclusionMax Conc.Concerns
SCCS/1598/1820-21 June 2019not safe-genotoxicity (DNA adduct formation; hydrogen peroxide generation)
SCCS/1482/1211 December 2012insufficient data-insufficient data; extreme skin sensitiser; genotoxicity unresolved
SCCP/0906/0528 March 2006insufficient data-genotoxicity unresolved; extreme sensitiser; inadequate data

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Colorant
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE ChEMBL / DailyMed CHEMBL3092389
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
2
View full pharmaceutical profile →

Frequently Asked Questions

What is the NOAEL for 1,2,4-Benzenetriol?

1,2,4-Benzenetriol has 22 NOAEL studies in the database. The lowest reported value is 50 mg/kg bw/day. Source: Regulatory source.

Is 1,2,4-Benzenetriol used in cosmetics?

Yes, 1,2,4-Benzenetriol is also indexed as a cosmetic ingredient under the name 1,2,4-Trihydroxybenzene. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 1,2,4-Benzenetriol come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Is 1,2,4-Benzenetriol used outside industrial chemicals?

1,2,4-Benzenetriol also appears in cosmetics, pharmaceutical databases.