What is the NOAEL for P-Methylhydrocinnamic aldehyde?
P-Methylhydrocinnamic aldehyde has 3 NOAEL studies in the database. The lowest reported value is 13.7 % via Dermal in Mouse. Source: NTP ICE skin sensitization.
NOAEL Data
Cosmetic Ingredient
P-Methylhydrocinnamic aldehyde
Also known as: EINECS 226-460-4, NSC 5304
CAS 5406-12-2
P-Methylhydrocinnamic aldehyde (CAS 5406-12-2) is a chemical substance. Key regulatory status: 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS.
View cosmetic safety profile for P-METHYLHYDROCINNAMIC ALDEHYDE →
SOURCE
NOAEL studies
NOAEL studies
3
SOURCE
Chemical inventory jurisdictions
Regulatory lists
1
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
7 fields
Name
P-Methylhydrocinnamic aldehyde
CAS Number
5406-12-2
Molecular Formula
C10H12O
InChI Key
ABGZWIFTZXUDGF-UHFFFAOYSA-N
Monoisotopic Mass
148.088815
Synonyms
EINECS 226-460-4NSC 5304
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
2 records
Fragrance
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
1 records
| List | Keyword | Source |
|---|---|---|
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 3 of 3 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 13.7 | % | EC3 | Dermal | Mouse | NTP ICE skin sensitization |
| 23.1 | % | EC3 | Dermal | Mouse | NTP ICE skin sensitization |
| 1RMD883W6C | UNII | FDA UNII substance identifier | - | - | openFDA substances |
Showing 3 of 3 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
SCCS Opinions
EU Scientific Committee opinions tied to the matched substance.
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SCCS Opinion
1 opinions
| Opinion | Date | Conclusion | Max Conc. | Concerns |
|---|---|---|---|---|
| SCCP/0868/05 | 15 March 2005 | The provided human and animal data demonstrate that Cresylpropionaldehyde (p-Methyldihydrocinnamaldehyde) is a contact allergen. However, under the conditions of its anticipated use as a fragrance ingredient (maximum 0.2% in the finished cosmetic product), the risk of sensitisation is low. | 0.2% | Contact allergen (skin sensitisation); risk of sensitisation low at max 0.2% use. Assessed for sensitisation only. |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
III/179
Category
Fragrance
Frequently Asked Questions
What regulatory lists include P-Methylhydrocinnamic aldehyde?
P-Methylhydrocinnamic aldehyde appears on 1 regulatory/inventory list including consumer_product. Source: EPA CPDat.
Is P-Methylhydrocinnamic aldehyde used in cosmetics?
Yes, P-Methylhydrocinnamic aldehyde is also indexed as a cosmetic ingredient under the name P-METHYLHYDROCINNAMIC ALDEHYDE. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for P-Methylhydrocinnamic aldehyde come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
Is P-Methylhydrocinnamic aldehyde used outside industrial chemicals?
P-Methylhydrocinnamic aldehyde also appears in cosmetics databases.