NOAEL Data SVHC REACH Registered Cosmetic Ingredient

Decamethylcyclopentasiloxane

Also known as: D5, 4-04-00-04128, BRN 1800166, EINECS 208-764-9, Silicon SF 1202 (+2 more)

CAS 541-02-6

Decamethylcyclopentasiloxane (CAS 541-02-6) is a chemical substance; key hazard signal: PBT (Article 57d); vPvB (Article 57e). Key regulatory status: SVHC Candidate List, REACH registered, 9 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH, ECHA SVHC.

View cosmetic safety profile for Cyclomethicone →

SOURCE NOAEL studies
NOAEL studies
54
SOURCE Chemical inventory jurisdictions
Regulatory lists
9
SOURCE EU CLP Annex VI
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 12 fields
Name
Decamethylcyclopentasiloxane
CAS Number
541-02-6
Molecular Formula
C10H30O5Si5
InChI Key
XMSXQFUHVRWGNA-UHFFFAOYSA-N
Monoisotopic Mass
370.093957
Synonyms
D54-04-00-04128BRN 1800166EINECS 208-764-9Silicon SF 1202DekamethylcyklopentasiloxanUNII-0THT5PCI0R

Substance of Very High Concern (SVHC)

Candidate List status and reason under the ECHA REACH SVHC program.

SOURCE ECHA 1 records
SubstanceReasonIncluded
DecamethylcyclopentasiloxanePBT (Article 57d); vPvB (Article 57e)27-Jun-2018

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 60 records
SolventLubricating agentEmulsifierSoftener and conditionerDiluentProcessing aids not otherwise specifiedFragranceSurface modifier

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 9 records
ListKeywordSource
Canada; pharmaceuticalDrugBankDrugBank
Europe; Personal careDanish Environmental Protection AgencyDanish EPA
Europe; Personal careDanish Environmental Protection AgencyDanish EPA
inert_ingredient; non_food_use; PesticidesEPACPCat
Europe; Other direct contact consumer goodsDanish Environmental Protection AgencyDanish EPA
CEDIFDAUnited States Food and Drug Administration (FDA)
detected; Europe; Other direct contact consumer goodsDanish Environmental Protection AgencyDanish EPA
IFRA TransparencyIFRAIFRA
EuropeEuropean Chemicals AgencyEuropean Chemicals Agency (ECHA)

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 54 studies
ValueUnitEndpointRouteSpeciesSource
5ppm-inhalationratRegulatory source
10%-oralratRegulatory source
10%-oral-Regulatory source
10%---Regulatory source
12----Regulatory source
17.8mg/kg bw/day-inhalation-Regulatory source
25ppm-inhalationratRegulatory source
25----Regulatory source
48%-oralratRegulatory source
0uL/min/10^6 cellsClint-HumanNTP ICE adme parameters
=24.2mg/m3DNEL localinhalationHumanToxValDB GESTIS DNEL
=97.3mg/m3DNEL systemicinhalationHumanToxValDB GESTIS DNEL
0THT5PCI0RUNIIFDA UNII substance identifier--openFDA substances
0.02%/secIntensityOcular-NTP ICE eye irritation
>8.259mg/LLC50Inhalation-NTP ICE acute inhalation
8.67mg/LLC50Inhalation-NTP ICE acute inhalation
>5000mg/kg bwLD50oralRatNTP ICE acute oral
>2.000e+4mg/kg bwLD50oralRatNTP ICE acute oral
>2.413e+4mg/kg bwLD50oralRatNTP ICE acute oral
>6.144e+4mg/kg bwLD50oralRatNTP ICE acute oral
>180sLag timeOcular-NTP ICE eye irritation
0unitlessModel Score--NTP ICE endocrine
=81mg/m3NOAECinhalationRatECHA
=606.6mg/m3NOAECinhalationRatECHA
>=1820mg/m3NOAECinhalationRatECHA
>=2350mg/m3NOAECinhalationRatECHA
>=2426mg/m3NOAECinhalationRatECHA
>=2441mg/m3NOAECinhalationRatECHA
>=3397mg/m3NOAECinhalationRatECHA
=5ppmNOAELinhalationratSCCS Opinion
=10%NOAELoralratSCCS Opinion
=12-NOAEL--SCCS Opinion
=17.8mg/kg bw/dayNOAELinhalation-SCCS Opinion
=25ppmNOAELinhalationratSCCS Opinion
=25-NOAEL--SCCS Opinion
=35-NOAEL--SCCS Opinion
=48%NOAELoralratSCCS Opinion
=96ppmNOAELinhalationratSCCS Opinion
=100mg/kg bw/dNOAELoral-SCCS Opinion
=100mg/kg bwNOAELoral-SCCS Opinion
=100mg/kgNOAELoralratSCCS Opinion
=160ppmNOAEL--SCCS Opinion
>=960mg/kg bw/dayNOAELdermalRabbitECHA
>=1000mg/kg bw/dayNOAELdermalRabbitECHA
=1000mg/kg bw/dNOAELoral-SCCS Opinion
>=1500mg/kg bw/dayNOAELoralRatECHA
>=1600mg/kg bw/dayNOAELdermalRatECHA
>=2002mg/m3NOAELinhalationRatECHA
>=2426mg/m3NOAELinhalationRatECHA
>2426mg/m3NOECinhalationRabbitECHA

Showing 50 of 54 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA 1 records
StatusNameEC NumberLink
RegisteredDecamethylcyclopentasiloxane208-764-9ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE SCCS Opinion 1 opinions
OpinionDateConclusionMax Conc.Concerns
SCCS/1549/1529 July 2016safe with restrictionsSafe at reported concentrations for most usesInhalation in aerosol products may exceed toxicologically safe air concentrations; reproductive/endocrine concerns; environmental restriction under REACH not covered

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
restricted
Max
D4: prohibited; D5+D4: ≤0.1% rinse-off (since Jan 31, 2020); D6: ≤0.1% rinse-off (effective June 6, 2026); D4+D5+D6: ≤0.1% leave-on (effective June 6, 2027)
Category
solvent
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE ChEMBL / DailyMed CHEMBL1885178
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
View full pharmaceutical profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for Decamethylcyclopentasiloxane?

Decamethylcyclopentasiloxane has 54 NOAEL studies in the database. The lowest reported value is 0 uL/min/10^6 cells in Human. Source: NTP ICE adme parameters.

What regulatory lists include Decamethylcyclopentasiloxane?

Decamethylcyclopentasiloxane appears on 8 regulatory/inventory lists including Canada; pharmaceutical, Europe; Personal care, inert_ingredient; non_food_use; Pesticides, and 5 more. Source: EPA CPDat.

Is Decamethylcyclopentasiloxane a Substance of Very High Concern (SVHC)?

Yes, Decamethylcyclopentasiloxane is listed on the ECHA REACH Candidate List as a Substance of Very High Concern. Reason: PBT (Article 57d); vPvB (Article 57e). Source: ECHA SVHC Candidate List.

Is Decamethylcyclopentasiloxane used in cosmetics?

Yes, Decamethylcyclopentasiloxane is also indexed as a cosmetic ingredient under the name Cyclomethicone. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Decamethylcyclopentasiloxane come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ECHA SVHC Candidate List, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Is Decamethylcyclopentasiloxane used outside industrial chemicals?

Decamethylcyclopentasiloxane also appears in cosmetics, pharmaceutical, cannabis databases.