What is the NOAEL for Decamethylcyclopentasiloxane?
Decamethylcyclopentasiloxane has 100 NOAEL studies in the database. The lowest reported value is 0 uL/min/10^6 cells in Human. Source: NTP_ICE_adme_parameters.
NOAEL Data
SVHC
REACH Registered
Cosmetic Ingredient
Decamethylcyclopentasiloxane
Also known as: D5, 4-04-00-04128, BRN 1800166, EINECS 208-764-9, Silicon SF 1202 (+2 more)
CAS 541-02-6
Decamethylcyclopentasiloxane (CAS 541-02-6) is a chemical substance; key hazard signal: PBT (Article 57d); vPvB (Article 57e). Key regulatory status: SVHC Candidate List, REACH registered, 9 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH, ECHA SVHC.
SOURCE
noael studies public
NOAEL studies
100
SOURCE
chemical inventory jurisdictions
Regulatory lists
9
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
13 fields
Name
Decamethylcyclopentasiloxane
CAS Number
541-02-6
DTXSID
DTXSID1027184
Molecular Formula
C10H30O5Si5
InChI Key
XMSXQFUHVRWGNA-UHFFFAOYSA-N
Monoisotopic Mass
370.093957
Synonyms
D54-04-00-04128BRN 1800166EINECS 208-764-9Silicon SF 1202DekamethylcyklopentasiloxanUNII-0THT5PCI0R
Substance of Very High Concern (SVHC)
Candidate List status and reason under the ECHA REACH SVHC program.
SOURCE
ECHA (EU)
1 records
| Substance | Reason | Included |
|---|---|---|
| Decamethylcyclopentasiloxane | PBT (Article 57d); vPvB (Article 57e) | 27-Jun-2018 |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
SolventLubricating agentEmulsifierSoftener and conditionerDiluentProcessing aids not otherwise specifiedFragranceSurface modifier
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
9 records
| List | Keyword | Source |
|---|---|---|
| Canada; pharmaceutical | DrugBank | DrugBank |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| CEDI | FDA | United States Food and Drug Administration (FDA) |
| detected; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| IFRA Transparency | IFRA | IFRA |
| Europe | European Chemicals Agency | European Chemicals Agency (ECHA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 50 of 100 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 5 | ppm | - | inhalation | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 10 | % | - | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 10 | % | - | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 10 | % | - | oral | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 10 | % | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 12 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 17.8 | mg/kg bw/day | - | inhalation | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 25 | ppm | - | inhalation | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 25 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 48 | % | - | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| - | uL/min/10^6 cells | Clint | - | Human | NTP_ICE_adme_parameters |
| =24.2 | mg/m3 | DNEL local | inhalation | Human | ToxValDB_GESTIS_DNEL |
| =97.3 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 0THT5PCI0R | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0THT5PCI0R | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0THT5PCI0R | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0THT5PCI0R | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.02 | %/sec | Intensity | Ocular | - | NTP_ICE_eye_irritation |
| >8.2595 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| 8.67 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| >5000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| >20000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| >24134 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| >61440 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| >180 | s | Lag time | Ocular | - | NTP_ICE_eye_irritation |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| =81 | mg/m3 | NOAEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =606.58 | mg/m3 | NOAEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| >=1819.74 | mg/m3 | NOAEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| >=2350 | mg/m3 | NOAEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| >=2426.32 | mg/m3 | NOAEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| >=2441.48 | mg/m3 | NOAEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| >=3396.85 | mg/m3 | NOAEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =5 | ppm | NOAEL | inhalation | rat | SCCS_vision_codex |
| =5 | ppm | NOAEL | inhalation | rat | SCCS_vision_codex |
| =5 | ppm | NOAEL | inhalation | rat | SCCS_vision_codex |
| =5 | ppm | NOAEL | inhalation | rat | SCCS_vision_codex |
| =10 | % | NOAEL | oral | rat | SCCS_vision_codex |
| =10 | % | NOAEL | oral | rat | SCCS_vision_codex |
| =10 | % | NOAEL | oral | rat | SCCS_vision_codex |
| =10 | % | NOAEL | oral | rat | SCCS_vision_codex |
| =12 | - | NOAEL | - | - | SCCS_vision_codex |
| =12 | - | NOAEL | - | - | SCCS_vision_codex |
| =12 | - | NOAEL | - | - | SCCS_vision_codex |
| =12 | - | NOAEL | - | - | SCCS_vision_codex |
| =17.8 | mg/kg bw/day | NOAEL | inhalation | - | SCCS_vision_codex |
| =17.8 | mg/kg bw/day | NOAEL | inhalation | - | SCCS_vision_codex |
| =17.8 | mg/kg bw/day | NOAEL | inhalation | - | SCCS_vision_codex |
| =17.8 | mg/kg bw/day | NOAEL | inhalation | - | SCCS_vision_codex |
| =25 | ppm | NOAEL | inhalation | rat | SCCS_vision_codex |
Showing 50 of 100 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Decamethylcyclopentasiloxane | 208-764-9 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
SCCS Opinions
EU Scientific Committee opinions tied to the matched substance.
SOURCE
EU SCCS
1 opinions
| Opinion | Date | Conclusion | Max Conc. | Concerns |
|---|---|---|---|---|
| SCCS/1549/15 | 29 July 2016 | safe with restrictions | Safe at reported concentrations for most uses | Inhalation in aerosol products may exceed toxicologically safe air concentrations; reproductive/endocrine concerns; environmental restriction under REACH not covered |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
D4: prohibited; D5+D4: ≤0.1% rinse-off (since Jan 31, 2020); D6: ≤0.1% rinse-off (effective June 6, 2026); D4+D5+D6: ≤0.1% leave-on (effective June 6, 2027)
Category
solvent
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL1885178
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Decamethylcyclopentasiloxane?
Decamethylcyclopentasiloxane appears on 8 regulatory/inventory lists including Canada; pharmaceutical, Europe; Personal care, inert_ingredient; non_food_use; Pesticides, and 5 more. Source: EPA CPDat.
Is Decamethylcyclopentasiloxane a Substance of Very High Concern (SVHC)?
Yes, Decamethylcyclopentasiloxane is listed on the ECHA REACH Candidate List as a Substance of Very High Concern. Reason: PBT (Article 57d); vPvB (Article 57e). Source: ECHA SVHC Candidate List.
Is Decamethylcyclopentasiloxane used in cosmetics?
Yes, Decamethylcyclopentasiloxane is also indexed as a cosmetic ingredient under the name Cyclomethicone. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Decamethylcyclopentasiloxane come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ECHA SVHC Candidate List, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Decamethylcyclopentasiloxane used outside industrial chemicals?
Decamethylcyclopentasiloxane also appears in cosmetics, pharmaceutical, cannabis databases.