NOAEL Data Cosmetic Ingredient

Octinoxate

Also known as: 2-Ethylhexyl 3-(4-methoxyphenyl)prop-2-enoate, 2-Ethylhexyl-4-methoxycinnamate, Ethylhexyl p-methoxycinnamate, 2-Propenoic acid, 3-(4-methoxyphenyl)-, 2-ethylhexyl ester, Octyl methoxycinnamate (+3 more)

CAS 5466-77-3

Octinoxate (CAS 5466-77-3) is a chemical substance. Key regulatory status: 14 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.

View cosmetic safety profile for Ethylhexyl Methoxycinnamate →

SOURCE noael studies public
NOAEL studies
44
SOURCE chemical inventory jurisdictions
Regulatory lists
14
SOURCE eu clp annex vi
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 14 fields
Name
Octinoxate
CAS Number
5466-77-3
DTXSID
DTXSID1025302
Molecular Formula
C18H26O3
InChI Key
YBGZDTIWKVFICR-UHFFFAOYSA-N
Monoisotopic Mass
290.188195
Synonyms
2-Ethylhexyl 3-(4-methoxyphenyl)prop-2-enoate2-Ethylhexyl-4-methoxycinnamateEthylhexyl p-methoxycinnamate2-Propenoic acid, 3-(4-methoxyphenyl)-, 2-ethylhexyl esterOctyl methoxycinnamateEINECS 226-775-7UNII-4Y5P7MUD51Ethylhexyl methoxycinnamate

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 51 records
FragranceUV stabilizer

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 14 records
ListKeywordSource
children; WA Children's Safe Product Act (4/2020)State of Washington Department of EcologyState of Washington
childrenVermont Department of HealthState of Vermont
childrenMaine Department of Environmental ProtectionState of Maine
childrenOregon Health AuthorityState of Oregon
detected; Europe; Personal care - nails - nail polishDanish Environmental Protection AgencyDanish EPA
IFRA TransparencyIFRAIFRA
detected; Europe; Toys and children's productsDanish Environmental Protection AgencyDanish EPA
Europe; Personal careDanish Environmental Protection AgencyDanish EPA
Europe; Personal careDanish Environmental Protection AgencyDanish EPA
Canada; pharmaceuticalDrugBankDrugBank
Canada; pharmaceuticalDrugBankDrugBank
active_ingredient; AustraliaAustralian Pesticides and Veterinary Medicines AuthorityCPCat
inert_ingredient; non_food_use; PesticidesEPACPCat
Europe; Personal careEuropean CommissionCosIng

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 44 of 44 studies
ValueUnitEndpointRouteSpeciesSource
4Y5P7MUD51UNIIFDA UNII substance identifier--openFDA substances
4Y5P7MUD51UNIIFDA UNII substance identifier--openFDA substances
4Y5P7MUD51UNIIFDA UNII substance identifier--openFDA substances
4Y5P7MUD51UNIIFDA UNII substance identifier--openFDA substances
=10%NOAELoralratSCCS_vision_codex
=10%NOAELoralratSCCS_vision_codex
=10%NOAELoralratSCCS_vision_codex
=10%NOAELoralratSCCS_vision_codex
=85-NOAEL--SCCS_vision_codex
=85-NOAEL--SCCS_vision_codex
=85-NOAEL--SCCS_vision_codex
=85-NOAEL--SCCS_vision_codex
=100mg/kg bw/dayNOAELoralratSCCS_vision_codex
=100mg/kg bw/dayNOAELoralratSCCS_vision_codex
=100mg/kg bw/dayNOAELoralratSCCS_vision_codex
=100mg/kg bw/dayNOAELoralratSCCS_vision_codex
=450mg/kg bw/dayNOAEL--SCCS_vision_codex
=450mg/kg bw/dayNOAEL--SCCS_vision_codex
=450mg/kg bw/dayNOAEL--SCCS_vision_codex
=450mg/kg bw/dayNOAEL--SCCS_vision_codex
=500mg/kg bw/dayNOAEL--SCCS_vision_codex
=500mg/kg bw/dayNOAEL--SCCS_vision_codex
=500mg/kg bw/dayNOAEL--SCCS_vision_codex
=500mg/kg bw/dayNOAEL--SCCS_vision_codex
=555mg/kg bw/dayNOAELinhalation-SCCS_vision_codex
=555mg/kg bw/dayNOAELinhalation-SCCS_vision_codex
=555mg/kg bw/dayNOAELinhalation-SCCS_vision_codex
=555mg/kg bw/dayNOAELinhalation-SCCS_vision_codex
=900mg/kg bw/dayNOAELdermalratSCCS_vision_codex
=900mg/kg bw/dayNOAELdermalratSCCS_vision_codex
=900mg/kg bw/dayNOAELdermalratSCCS_vision_codex
=900mg/kg bw/dayNOAELdermalratSCCS_vision_codex
=1000mg/kg bw/dayNOAEL--SCCS_vision_codex
=1000mg/kg bw/dayNOAEL--SCCS_vision_codex
=1000mg/kg bw/dayNOAEL--SCCS_vision_codex
=1000mg/kg bw/dayNOAEL--SCCS_vision_codex
=1500mg/kg bw/dayNOAEL-ratSCCS_vision_codex
=1500mg/kg bw/dayNOAEL-ratSCCS_vision_codex
=1500mg/kg bw/dayNOAEL-ratSCCS_vision_codex
=1500mg/kg bw/dayNOAEL-ratSCCS_vision_codex
=5000mg/kg bw/dayNOAELdermal-SCCS_vision_codex
=5000mg/kg bw/dayNOAELdermal-SCCS_vision_codex
=5000mg/kg bw/dayNOAELdermal-SCCS_vision_codex
=5000mg/kg bw/dayNOAELdermal-SCCS_vision_codex

Showing 44 of 44 studies

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
restricted
Max
10%
Category
uv-filter
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL OCTINOXATE
ChEMBL Phase
4
Adverse Events
44
Bioactivity
2
View full pharmaceutical profile →

Frequently Asked Questions

What is the NOAEL for Octinoxate?

Octinoxate has 44 NOAEL studies in the database. The lowest reported value is 4Y5P7MUD51 UNII. Source: openFDA substances.

What regulatory lists include Octinoxate?

Octinoxate appears on 9 regulatory/inventory lists including children; WA Children's Safe Product Act (4/2020), children, detected; Europe; Personal care - nails - nail polish, and 6 more. Source: EPA CPDat.

Is Octinoxate used in cosmetics?

Yes, Octinoxate is also indexed as a cosmetic ingredient under the name Ethylhexyl Methoxycinnamate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Octinoxate come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Is Octinoxate used outside industrial chemicals?

Octinoxate also appears in cosmetics, pharmaceutical databases.