What is the NOAEL for 3,3′-(1,4-Phenylene)bis[5,6-diphenyl-1,2,4-triazine]?
3,3′-(1,4-Phenylene)bis[5,6-diphenyl-1,2,4-triazine] has 22 NOAEL studies in the database. The lowest reported value is 48.5 % via oral in rat. Source: SCCS Opinion.
NOAEL Data
REACH Registered
Cosmetic Ingredient
3,3′-(1,4-Phenylene)bis[5,6-diphenyl-1,2,4-triazine]
CAS 55514-22-2
3,3′-(1,4-Phenylene)bis[5,6-diphenyl-1,2,4-triazine] (CAS 55514-22-2) is a chemical substance. Key regulatory status: REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, SCCS, ECHA REACH.
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NOAEL studies
NOAEL studies
22
SOURCE
Chemical inventory jurisdictions
Regulatory lists
2
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EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
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DSSTox identifiers
5 fields
Name
3,3′-(1,4-Phenylene)bis[5,6-diphenyl-1,2,4-triazine]
CAS Number
55514-22-2
Molecular Formula
C36H24N6
InChI Key
NZTWOIMQWMZIRE-UHFFFAOYSA-N
Monoisotopic Mass
540.206244797
Functional Uses
Industrial and product-use categories associated with this substance.
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EPA CPDat
3 records
Stabilizing agentUV stabilizer
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
2 records
| List | Keyword | Source |
|---|---|---|
| Europe | - | https://ec.europa.eu/growth/tools-databases/cosing/index.cfm?fuseaction=search.simple |
| Personal care | - | https://ec.europa.eu/growth/tools-databases/cosing/index.cfm?fuseaction=search.simple |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 22 of 22 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 54 | mg/kg bw/day | - | inhalation | - | Regulatory source |
| 1000 | mg/kg/day | - | - | - | Regulatory source |
| 1000 | mg/kg/day | - | oral | rat | Regulatory source |
| =48.5 | % | NOAEL | oral | rat | SCCS Opinion |
| =54 | mg/kg bw/day | NOAEL | inhalation | - | SCCS Opinion |
| =80 | mg/kg bw | NOAEL | dermal | rat | SCCS Opinion |
| =464 | mg/kg bw/day | NOAEL | oral | rat | SCCS Opinion |
| =464 | mg/kg bw/d | NOAEL | oral | - | SCCS Opinion |
| =485 | mg/kg/day | NOAEL | oral | rat | SCCS Opinion |
| =1000 | mg/kg bw/day | NOAEL | - | - | SCCS Opinion |
| =1000 | mg/kg/day | NOAEL | - | - | SCCS Opinion |
| =1000 | mg/kg bw/day | NOEL | oral | Rat | ECHA |
| 464 | mg/kg bw/day | developmental toxicity | oral | rat | Regulatory source |
| 1000 | mg/kg bw/day | developmental toxicity | - | - | Regulatory source |
| 80 | mg/kg bw | irritation | dermal | rat | Regulatory source |
| 48.5 | % | repeated dose toxicity | oral | rat | Regulatory source |
| 54 | mg/kg bw/day | repeated dose toxicity | inhalation | rat | Regulatory source |
| 485 | mg/kg/day | repeated dose toxicity | oral | rat | Regulatory source |
| 1000 | mg/kg bw/day | repeated dose toxicity | - | - | Regulatory source |
| 1000 | mg/kg/day | repeated dose toxicity | oral | rat | Regulatory source |
| 464 | mg/kg bw/d | reproductive toxicity | oral | - | Regulatory source |
| 1000 | mg/kg/day | reproductive toxicity | - | rat | Regulatory source |
Showing 22 of 22 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
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ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 3,3'-(1,4-Phenylene)bis(5,6-diphenyl-1,2,4-triazine) | 700-823-1 | ECHA overview → |
SCCS Opinions
EU Scientific Committee opinions tied to the matched substance.
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SCCS Opinion
2 opinions
| Opinion | Date | Conclusion | Max Conc. | Concerns |
|---|---|---|---|---|
| SCCS/1594/18 | 30 July 2018 | safe with restrictions | up to 5% | CMR 1B impurities NMP and hydrazine identified as SVHC - must be kept at trace levels; poor biodegradation; high octanol-water partition coefficient |
| SCCS/1556/15 | 13 July 2015 | safe with restrictions | 5% as UV filter | No systemic concern at 5%; secondary amine - potential nitrosamine formation; not for use with nitrosating agents; inhalation safety not assessed |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
5%
Category
sunscreen
Frequently Asked Questions
What regulatory lists include 3,3′-(1,4-Phenylene)bis[5,6-diphenyl-1,2,4-triazine]?
3,3′-(1,4-Phenylene)bis[5,6-diphenyl-1,2,4-triazine] appears on 2 regulatory/inventory lists including Europe, Personal care. Source: EPA CPDat.
Is 3,3′-(1,4-Phenylene)bis[5,6-diphenyl-1,2,4-triazine] used in cosmetics?
Yes, 3,3′-(1,4-Phenylene)bis[5,6-diphenyl-1,2,4-triazine] is also indexed as a cosmetic ingredient under the name TriAsorB. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 3,3′-(1,4-Phenylene)bis[5,6-diphenyl-1,2,4-triazine] come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
Is 3,3′-(1,4-Phenylene)bis[5,6-diphenyl-1,2,4-triazine] used outside industrial chemicals?
3,3′-(1,4-Phenylene)bis[5,6-diphenyl-1,2,4-triazine] also appears in cosmetics databases.