NOAEL Data REACH Registered Cosmetic Ingredient

3,3′-(1,4-Phenylene)bis[5,6-diphenyl-1,2,4-triazine]

CAS 55514-22-2

3,3′-(1,4-Phenylene)bis[5,6-diphenyl-1,2,4-triazine] (CAS 55514-22-2) is a chemical substance. Key regulatory status: REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, SCCS, ECHA REACH.

View cosmetic safety profile for TriAsorB →

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 6 fields

Name

3,3′-(1,4-Phenylene)bis[5,6-diphenyl-1,2,4-triazine]

CAS Number

55514-22-2

DTXSID

DTXSID601045085

Molecular Formula

C36H24N6

InChI Key

NZTWOIMQWMZIRE-UHFFFAOYSA-N

Monoisotopic Mass

540.206244797

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 3 records

Stabilizing agentUV stabilizer

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 2 records

List	Keyword	Source
Europe	-	https://ec.europa.eu/growth/tools-databases/cosing/index.cfm?fuseaction=search.simple
Personal care	-	https://ec.europa.eu/growth/tools-databases/cosing/index.cfm?fuseaction=search.simple

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 51 studies

Value	Unit	Endpoint	Route	Species	Source
54	mg/kg bw/day	-	inhalation	-	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
1000	mg/kg/day	-	-	-	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
1000	mg/kg/day	-	oral	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
=48.5	%	NOAEL	oral	rat	SCCS_vision_codex
=48.5	%	NOAEL	oral	rat	SCCS_vision_codex
=48.5	%	NOAEL	oral	rat	SCCS_vision_codex
=48.5	%	NOAEL	oral	rat	SCCS_vision_codex
=54	mg/kg bw/day	NOAEL	inhalation	-	SCCS_vision_codex
=54	mg/kg bw/day	NOAEL	inhalation	-	SCCS_vision_codex
=54	mg/kg bw/day	NOAEL	inhalation	-	SCCS_vision_codex
=54	mg/kg bw/day	NOAEL	inhalation	-	SCCS_vision_codex
=80	mg/kg bw	NOAEL	dermal	rat	SCCS_vision_codex
=80	mg/kg bw	NOAEL	dermal	rat	SCCS_vision_codex
=80	mg/kg bw	NOAEL	dermal	rat	SCCS_vision_codex
=80	mg/kg bw	NOAEL	dermal	rat	SCCS_vision_codex
=464	mg/kg bw/day	NOAEL	oral	rat	SCCS_vision_codex
=464	mg/kg bw/d	NOAEL	oral	-	SCCS_vision_codex
=464	mg/kg bw/day	NOAEL	oral	rat	SCCS_vision_codex
=464	mg/kg bw/d	NOAEL	oral	-	SCCS_vision_codex
=464	mg/kg bw/day	NOAEL	oral	rat	SCCS_vision_codex
=464	mg/kg bw/d	NOAEL	oral	-	SCCS_vision_codex
=464	mg/kg bw/day	NOAEL	oral	rat	SCCS_vision_codex
=464	mg/kg bw/d	NOAEL	oral	-	SCCS_vision_codex
=485	mg/kg/day	NOAEL	oral	rat	SCCS_vision_codex
=485	mg/kg/day	NOAEL	oral	rat	SCCS_vision_codex
=485	mg/kg/day	NOAEL	oral	rat	SCCS_vision_codex
=485	mg/kg/day	NOAEL	oral	rat	SCCS_vision_codex
=1000	mg/kg bw/day	NOAEL	-	-	SCCS_vision_codex
=1000	mg/kg/day	NOAEL	-	-	SCCS_vision_codex
=1000	mg/kg bw/day	NOAEL	-	-	SCCS_vision_codex
=1000	mg/kg/day	NOAEL	-	-	SCCS_vision_codex
=1000	mg/kg bw/day	NOAEL	-	-	SCCS_vision_codex
=1000	mg/kg/day	NOAEL	-	-	SCCS_vision_codex
=1000	mg/kg bw/day	NOAEL	-	-	SCCS_vision_codex
=1000	mg/kg/day	NOAEL	-	-	SCCS_vision_codex
=1000	mg/kg bw/day	NOEL	oral	Rat	ToxValDB_ECHA_IUCLID
464	mg/kg bw/day	developmental toxicity	oral	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
1000	mg/kg bw/day	developmental toxicity	-	-	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
80	mg/kg bw	irritation	dermal	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
48.5	%	repeated dose toxicity	oral	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
54	mg/kg bw/day	repeated dose toxicity	inhalation	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
485	mg/kg/day	repeated dose toxicity	oral	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
485	mg/kg/day	repeated dose toxicity	oral	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
1000	mg/kg bw/day	repeated dose toxicity	-	-	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
1000	mg/kg/day	repeated dose toxicity	oral	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
1000	mg/kg/day	repeated dose toxicity	oral	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
1000	mg/kg/day	repeated dose toxicity	oral	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
1000	mg/kg/day	repeated dose toxicity	oral	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
1000	mg/kg/day	repeated dose toxicity	oral	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
464	mg/kg bw/d	reproductive toxicity	oral	-	UnifiedCodex:SCCS_SHADOW:beta.noael_studies

Showing 50 of 51 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	3,3'-(1,4-Phenylene)bis(5,6-diphenyl-1,2,4-triazine)	700-823-1	ECHA overview →

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE EU SCCS 2 opinions

Opinion	Date	Conclusion	Max Conc.	Concerns
SCCS/1594/18	30 July 2018	safe with restrictions	up to 5%	CMR 1B impurities NMP and hydrazine identified as SVHC - must be kept at trace levels; poor biodegradation; high octanol-water partition coefficient
SCCS/1556/15	13 July 2015	safe with restrictions	5% as UV filter	No systemic concern at 5%; secondary amine - potential nitrosamine formation; not for use with nitrosating agents; inhalation safety not assessed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

restricted

Max

Frequently Asked Questions

What is the NOAEL for 3,3′-(1,4-Phenylene)bis[5,6-diphenyl-1,2,4-triazine]?

3,3′-(1,4-Phenylene)bis[5,6-diphenyl-1,2,4-triazine] has 51 NOAEL studies in the database. The lowest reported value is 48.5 % via oral in rat. Source: SCCS_vision_codex.

What regulatory lists include 3,3′-(1,4-Phenylene)bis[5,6-diphenyl-1,2,4-triazine]?

3,3′-(1,4-Phenylene)bis[5,6-diphenyl-1,2,4-triazine] appears on 2 regulatory/inventory lists including Europe, Personal care. Source: EPA CPDat.

Is 3,3′-(1,4-Phenylene)bis[5,6-diphenyl-1,2,4-triazine] used in cosmetics?

Yes, 3,3′-(1,4-Phenylene)bis[5,6-diphenyl-1,2,4-triazine] is also indexed as a cosmetic ingredient under the name TriAsorB. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 3,3′-(1,4-Phenylene)bis[5,6-diphenyl-1,2,4-triazine] come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.

Is 3,3′-(1,4-Phenylene)bis[5,6-diphenyl-1,2,4-triazine] used outside industrial chemicals?

3,3′-(1,4-Phenylene)bis[5,6-diphenyl-1,2,4-triazine] also appears in cosmetics databases.