NOAEL Data REACH Registered Cosmetic Ingredient

L-Serine

CAS 56-45-1

L-Serine (CAS 56-45-1) is a chemical substance. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH.

View cosmetic safety profile for L-Serine →

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 6 fields

Name

L-Serine

CAS Number

56-45-1

DTXSID

DTXSID60883230

Molecular Formula

C3H7NO3

InChI Key

MTCFGRXMJLQNBG-REOHCLBHSA-N

Monoisotopic Mass

105.042593

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 3 records

Flavouring and nutrient

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 3 records

List	Keyword	Source
Canada; consumer_product; Substances in Products - Canada (4/2014)	Government of Canada	CPCat
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)	FDA	United States Food and Drug Administration (FDA)
pharmaceutical	US International Trade Commission	CPCat

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 10 of 10 studies

Value	Unit	Endpoint	Route	Species	Source
=529	mg/m3	DNEL systemic	inhalation	Human	ToxValDB_GESTIS_DNEL
452VLY9402	UNII	FDA UNII substance identifier	-	-	openFDA substances
452VLY9402	UNII	FDA UNII substance identifier	-	-	openFDA substances
452VLY9402	UNII	FDA UNII substance identifier	-	-	openFDA substances
452VLY9402	UNII	FDA UNII substance identifier	-	-	openFDA substances
=2765	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=2905.1	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=799.9	mg/kg bw/day	NOEL	oral	Rat	ToxValDB_ECHA_IUCLID
=903.9	mg/kg bw/day	NOEL	oral	Rat	ToxValDB_ECHA_IUCLID
=3000	mg/kg bw/day	NOEL	oral	Rat	ToxValDB_ECHA_IUCLID

Showing 10 of 10 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	L-serine	200-274-3	ECHA overview →

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL SERINE

ChEMBL Phase

Adverse Events

Bioactivity

View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

1 food-safety record found.

View full food safety profile →

Frequently Asked Questions

What is the NOAEL for L-Serine?

L-Serine has 10 NOAEL studies in the database. The lowest reported value is 529 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.

What regulatory lists include L-Serine?

L-Serine appears on 3 regulatory/inventory lists including Canada; consumer_product; Substances in Products - Canada (4/2014), food_additive; Substances Added to Food (formerly EAFUS) (2/2019), pharmaceutical. Source: EPA CPDat.

Is L-Serine used in cosmetics?

Yes, L-Serine is also indexed as a cosmetic ingredient under the name L-Serine. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for L-Serine come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.

Is L-Serine used outside industrial chemicals?

L-Serine also appears in cosmetics, pharmaceutical, food safety databases.