What is the NOAEL for Glycerol?
Glycerol has 100 NOAEL studies in the database. The lowest reported value is -4.8 % via Dermal. Source: NTP_ICE_skin_sensitization.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Glycerol
Also known as: 1,2,3-Propanetriol, Glycerin, 1,2,3-Trihydroxypropane, Propanetriol, 4-01-00-02751 (+15 more)
CAS 56-81-5
Glycerol (CAS 56-81-5) is a chemical substance. Key regulatory status: REACH registered, 60 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH, ILO ICSC, OSHA.
SOURCE
noael studies public
NOAEL studies
100
SOURCE
chemical inventory jurisdictions
Regulatory lists
60
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
Glycerol
CAS Number
56-81-5
DTXSID
DTXSID9020663
Molecular Formula
C3H8O3
InChI Key
PEDCQBHIVMGVHV-UHFFFAOYSA-N
Monoisotopic Mass
92.047344
Synonyms
1,2,3-PropanetriolGlycerin1,2,3-TrihydroxypropanePropanetriol4-01-00-0275190 Technical glycerineBRN 0635685Caswell No. 469Citifluor AF 2DagralaxEINECS 200-289-5EPA Pesticide Chemical Code 063507
OSHA Exposure Limits
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
SOURCE
OSHA / NIOSH / ACGIH occupational exposure limits
3 records
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| OSHA | TWA | 15 mg/m³ (total dust), 5 mg/m³ (respirable) | - | 15 | N |
| ACGIH | TWA | See Appendix B: Particles (insoluble or poorly soluble) Not Otherwise Specified (PNOS) | - | - | N |
| CAL/OSHA | TWA | 10 mg/m³ (total dust), 5 mg/m³ (respirable fraction) | - | 10 | N |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
SolventEmulsifierHumectantSoftener and conditionerProcessing aids not otherwise specifiedStabilizing agent
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
60 records
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; Pesticides | EPA | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - specialized bath products - bath salts | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - general moisturizing - hand/body lotion | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - body hygiene - body wash | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - hair styling and care - shampoo | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - specialized bath products - bubble bath | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - dental care - toothpaste | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - liniment | Danish Environmental Protection Agency | Danish EPA |
| consumer_product; Europe | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Personal care - sexual wellness | MDPI | Published Articles |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Europe; Personal care - oral and dental care - teeth whitener | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - fabric treatment and dye; detected | Danish Environmental Protection Agency | Danish EPA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| active_ingredient; Pesticides | California Department of Pesticide Regulation | State of California |
| Arts and crafts/Office supplies - home office - pens and markers; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - home office - pens and markers; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - fabric treatment and dye; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care; Europe | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - laundry and fabric treatment - laundry stain remover; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - laundry and fabric treatment - laundry stain remover; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| animal_products | USDA | United States Department of Agriculture (USDA) |
| Europe; Personal care - liniment | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts adhesive; Europe | Danish Environmental Protection Agency | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 50 of 100 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =20 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v48je16 |
| =20 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v48je16 |
| =25 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v48je16 |
| =25 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v48je16 |
| >200 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| >644.658 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| 833.3 | ug/mL | CV75 | Dermal | - | NTP_ICE_skin_sensitization |
| >5000 | ug/mL | CV75 | Dermal | - | NTP_ICE_skin_sensitization |
| -3.8 | % | Depletion Cys | Dermal | - | NTP_ICE_skin_sensitization |
| -1.1 | % | Depletion Cys | Dermal | - | NTP_ICE_skin_sensitization |
| -0.7 | % | Depletion Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 1.2 | % | Depletion Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 1.8 | % | Depletion Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 2.5 | % | Depletion Cys | Dermal | - | NTP_ICE_skin_sensitization |
| -4.8 | % | Depletion Lys | Dermal | - | NTP_ICE_skin_sensitization |
| - | % | Depletion Lys | Dermal | - | NTP_ICE_skin_sensitization |
| 0.1 | % | Depletion Lys | Dermal | - | NTP_ICE_skin_sensitization |
| 0.8 | % | Depletion Lys | Dermal | - | NTP_ICE_skin_sensitization |
| 1.3 | % | Depletion Lys | Dermal | - | NTP_ICE_skin_sensitization |
| 2.1 | % | Depletion Lys | Dermal | - | NTP_ICE_skin_sensitization |
| 0.3 | % | Depletion Lys + Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 0.6 | % | Depletion Lys + Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 0.95 | % | Depletion Lys + Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 1.05 | % | Depletion Lys + Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 1.65 | % | Depletion Lys + Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 1.7 | unitless | Draize rabbit irritation score | Ocular | Rabbit | NTP_ICE_eye_irritation |
| 1.7 | unitless | Draize rabbit irritation score | Ocular | Rabbit | NTP_ICE_eye_irritation |
| 1.7 | unitless | Draize rabbit irritation score | Ocular | Rabbit | NTP_ICE_eye_irritation |
| 1.7 | unitless | Draize rabbit irritation score | Ocular | Rabbit | NTP_ICE_eye_irritation |
| 1793.9 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| >2000 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| 4 | unitless | EPA Classification | Ocular | Rabbit | NTP_ICE_eye_irritation |
| 4 | unitless | EPA Classification | Ocular | Rabbit | NTP_ICE_eye_irritation |
| 4 | unitless | EPA Classification | Ocular | Rabbit | NTP_ICE_eye_irritation |
| 4 | unitless | EPA Classification | Ocular | Rabbit | NTP_ICE_eye_irritation |
| PDC6A3C0OX | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| PDC6A3C0OX | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| PDC6A3C0OX | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| PDC6A3C0OX | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >2400 | uM | IC50 | Dermal | - | NTP_ICE_skin_sensitization |
| 1.024 | ratio | Imax | Dermal | - | NTP_ICE_skin_sensitization |
| 1.032 | ratio | Imax | Dermal | - | NTP_ICE_skin_sensitization |
| 1.1 | ratio | Imax | Dermal | - | NTP_ICE_skin_sensitization |
| 1.12 | ratio | Imax | Dermal | - | NTP_ICE_skin_sensitization |
| 1.127 | ratio | Imax | Dermal | - | NTP_ICE_skin_sensitization |
| 1.13 | ratio | Imax | Dermal | - | NTP_ICE_skin_sensitization |
| 1.134 | ratio | Imax | Dermal | - | NTP_ICE_skin_sensitization |
| 1.146 | ratio | Imax | Dermal | - | NTP_ICE_skin_sensitization |
| 1.156 | ratio | Imax | Dermal | - | NTP_ICE_skin_sensitization |
| 1.16 | ratio | Imax | Dermal | - | NTP_ICE_skin_sensitization |
Showing 50 of 100 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Glycerol | 200-289-5 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
humectant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
GLYCERIN
ChEMBL Phase
4
Adverse Events
940
Bioactivity
3
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
2 records
ADI: NOT SPECIFIED (1976) mg/kg bw | FDA GRAS: FDA has no questions
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Glycerol?
Glycerol appears on 30 regulatory/inventory lists including inert_ingredient; Pesticides, inert_ingredient; non_food_use; Pesticides, Europe; Personal care, and 27 more. Source: EPA CPDat.
What are the occupational exposure limits for Glycerol?
Occupational exposure limits for Glycerol are set by OSHA, ACGIH, CAL/OSHA. 3 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Is Glycerol used in cosmetics?
Yes, Glycerol is also indexed as a cosmetic ingredient under the name Glycerin. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Glycerol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Glycerol used outside industrial chemicals?
Glycerol also appears in cosmetics, pharmaceutical, food safety, cannabis databases.