NOAEL Data REACH Registered Cosmetic Ingredient

Sucralose

Also known as: Predillon SU 600, 4,1',6'-Trichloro-4,1',6'-trideoxygalactosucrose, Sansweet SU 100, Splenda, α-​D-​Galactopyranoside, 1,​6-​dichloro-​1,​6-​dideoxy-​β-​D-​fructofuranosyl 4-​chloro-​4-​deoxy- (+14 more)

CAS 56038-13-2

Sucralose (CAS 56038-13-2) is a chemical substance. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for Sucralose →

SOURCE noael studies public
NOAEL studies
34
SOURCE chemical inventory jurisdictions
Regulatory lists
4
SOURCE eu clp annex vi
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 25 fields
Name
Sucralose
CAS Number
56038-13-2
DTXSID
DTXSID1040245
Molecular Formula
C12H19Cl3O8
InChI Key
BAQAVOSOZGMPRM-QBMZZYIRSA-N
Monoisotopic Mass
396.014551
Synonyms
Predillon SU 6004,1',6'-Trichloro-4,1',6'-trideoxygalactosucroseSansweet SU 100Splendaα-​D-​Galactopyranoside, 1,​6-​dichloro-​1,​6-​dideoxy-​β-​D-​fructofuranosyl 4-​chloro-​4-​deoxy-1,6-Dichloro-1,6-dideoxy-β-D-fructofuranosyl 4-chloro-4-deoxy-α-D-galactopyranoside1',4,6'-TrichlorogalactosucroseSan Sweet SA 8020Sansweet SU 200Sucrazit1,6-dichloro-1,6-dideoxy-β-D-fructofuranosyl 4-chloro-4-deoxy-α-D-galactoseEC No.: 259-952-2

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 60 records
Softener and conditionerFlavouring and nutrientFragrance

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 4 records
ListKeywordSource
Canada; consumer_product; Substances in Products - Canada (4/2014)Government of CanadaCPCat
IFRA TransparencyIFRAIFRA
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)FDAUnited States Food and Drug Administration (FDA)
Europe; Personal care - oral and dental care - teeth whitenerDanish Environmental Protection AgencyDanish EPA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 34 of 34 studies
ValueUnitEndpointRouteSpeciesSource
<=15mg/kgADIoralHumanToxValDB_WHO_JECFA_ADI
<=15mg/kg bw/dayADI-ConsumersEFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx
<=15mg/kg bw/dayADI-ConsumersEFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx
96K6UQ3ZD4UNIIFDA UNII substance identifier--openFDA substances
96K6UQ3ZD4UNIIFDA UNII substance identifier--openFDA substances
96K6UQ3ZD4UNIIFDA UNII substance identifier--openFDA substances
96K6UQ3ZD4UNIIFDA UNII substance identifier--openFDA substances
296mg/kg bw/dayLOAELoraldogCOSMOS_DB
>=3000ppmLOAELoralRatToxValDB_ECHA_IUCLID
>=10000ppmLOAELoralRatToxValDB_ECHA_IUCLID
>=30000ppmLOAELoralRatToxValDB_ECHA_IUCLID
~750mg/kg bw/dayLOELoralRatToxValDB_ECHA_IUCLID
=2000mg/kg bw/dayLOELoralMouseToxValDB_ECOTOX
91mg/kg bw/dayNOAELoraldogCOSMOS_DB
119mg/kg bw/dayNOAELoralratCOSMOS_DB
150mg/kg bw/dayNOAELoralratCOSMOS_DB
233mg/kg bw/dayNOAELoralratCOSMOS_DB
296mg/kg bw/dayNOAELoraldogCOSMOS_DB
500mg/kg bw/dayNOAELoralratCOSMOS_DB
700mg/kg bw/dayNOAELoralrabbitCOSMOS_DB
750mg/kg bw/dayNOAELoralrabbitCOSMOS_DB
1000mg/kg bw/dayNOAELoralmonkeyCOSMOS_DB
>1000mg/kg bw/dayNOAELoralRabbitToxValDB_ECHA_IUCLID
1500mg/kg bw/dayNOAELoralratCOSMOS_DB
2000mg/kg bw/dayNOAELoralratCOSMOS_DB
>2340mg/kg bw/dayNOAELoralRatToxValDB_ECHA_IUCLID
2500mg/kg bw/dayNOAELoralratCOSMOS_DB
2965mg/kg bw/dayNOAELoralmouseCOSMOS_DB
3000mg/kg bw/dayNOAELoralratCOSMOS_DB
>3000mg/kg bw/dayNOAELoralRatToxValDB_ECHA_IUCLID
4000mg/kg bw/dayNOAELoralratCOSMOS_DB
5000mg/kg bw/dayNOAELoralratCOSMOS_DB
=350mg/kg bw/dayNOELoralRabbitToxValDB_ECHA_IUCLID
=1000mg/kg bw/dayNOELoralMouseToxValDB_ECOTOX

Showing 34 of 34 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records
StatusNameEC NumberLink
Registered1,6-dichloro-1,6-dideoxy-β-D-fructofuranosyl 4-chloro-4-deoxy-α-D-galactose259-952-2ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed_with_terms
Conditions
Specific information requirements: Obligations to provide information apply. You must tell us within 28 days if the circumstances of your importation or manufacture (introduction) are different to those in our assessment.

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
permitted
Max
1%
Category
Other
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL SUCRALOSE
ChEMBL Phase
3
Adverse Events
9
Bioactivity
2
View full pharmaceutical profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for Sucralose?

Sucralose has 34 NOAEL studies in the database. The lowest reported value is 15 mg/kg via oral in Human. Source: ToxValDB_WHO_JECFA_ADI.

What regulatory lists include Sucralose?

Sucralose appears on 4 regulatory/inventory lists including Canada; consumer_product; Substances in Products - Canada (4/2014), IFRA Transparency, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), and 1 more. Source: EPA CPDat.

Is Sucralose used in cosmetics?

Yes, Sucralose is also indexed as a cosmetic ingredient under the name Sucralose. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Sucralose come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Is Sucralose used outside industrial chemicals?

Sucralose also appears in cosmetics, pharmaceutical, cannabis databases.