What is the NOAEL for (3aR)-(+)-Sclareolide?
(3aR)-(+)-Sclareolide has 6 NOAEL studies in the database. The lowest reported value is 16.4 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
(3aR)-(+)-Sclareolide
Also known as: Decahydrotetramethylnaphthofuranone, 3a,4,5,5aalpha,6,7,8,9,9a,9balpha-decahydro-3abeta,6,6,9abeta-tetramethylnaphtho(2,1-b)furan-2(1H)-one, Decahydro-3a,6,6,9a-tetramethylnaphtho(2,1-b)furan-2(1H)-one, EINECS 209-269-0, Naphtho(2,1-b)furan-2(1H)-one, 3a,4,5,5aalpha,6,7,8,9,9a,9balpha-decahydro-3abeta,6,6,9abeta-tetramethyl- (+6 more)
CAS 564-20-5
(3aR)-(+)-Sclareolide (CAS 564-20-5) is a chemical substance. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
6
SOURCE
chemical inventory jurisdictions
Regulatory lists
3
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
17 fields
Name
(3aR)-(+)-Sclareolide
CAS Number
564-20-5
DTXSID
DTXSID8047686
Molecular Formula
C16H26O2
InChI Key
IMKJGXCIJJXALX-SHUKQUCYSA-N
Monoisotopic Mass
250.19328
Synonyms
Decahydrotetramethylnaphthofuranone3a,4,5,5aalpha,6,7,8,9,9a,9balpha-decahydro-3abeta,6,6,9abeta-tetramethylnaphtho(2,1-b)furan-2(1H)-oneDecahydro-3a,6,6,9a-tetramethylnaphtho(2,1-b)furan-2(1H)-oneEINECS 209-269-0Naphtho(2,1-b)furan-2(1H)-one, 3a,4,5,5aalpha,6,7,8,9,9a,9balpha-decahydro-3abeta,6,6,9abeta-tetramethyl-Naphtho(2,1-b)furan-2(1H)-one, decahydro-3a,6,6,9a-tetramethyl-, (3aR-(3aalpha,5abeta,9aalpha,9bbeta))-Norambreinolide, (+)-12-NorambreinolideUNII-37W4O0O6E6(+)-SclareolideSclareolide
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
6 records
DeodorizerSoftener and conditionerFragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 6 of 6 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =16.4 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 37W4O0O6E6 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 37W4O0O6E6 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 37W4O0O6E6 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 37W4O0O6E6 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =1000 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
Showing 6 of 6 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | [3aR-(3aα,5aβ,9aα,9bβ)]decahydro-3a,6,6,9a-tetramethylnaphth[2,1-b]furan-2(1H)-one | 209-269-0 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL304461
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
3
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: No safety concern at current levels of intake when used s a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include (3aR)-(+)-Sclareolide?
(3aR)-(+)-Sclareolide appears on 3 regulatory/inventory lists including IFRA Transparency, Europe, food_additive; Substances Added to Food (formerly EAFUS) (2/2019). Source: EPA CPDat.
Is (3aR)-(+)-Sclareolide used in cosmetics?
Yes, (3aR)-(+)-Sclareolide is also indexed as a cosmetic ingredient under the name Sclareolide. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for (3aR)-(+)-Sclareolide come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is (3aR)-(+)-Sclareolide used outside industrial chemicals?
(3aR)-(+)-Sclareolide also appears in cosmetics, pharmaceutical, food safety, cannabis databases.